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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008,14,11: | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010,16,25: | 13 |
| 3 | Occurrence of perfluoroalkyl acids in precipitation from Shenyang,China显示文摘Perfluorosulfonates (PFSAs) and perfluorocarboxylates (PFCAs) in precipitation collected from Shenyang, China were determined. Snow samples were collected in the snow event on March 4, 2007 from 34 sites involving both the urban and suburban areas in Shenyang. The snowmelt was preconcentrated by solid phase extraction and analyzed using LC-MS method. Measurable amounts of perfluoroalkyl acids (PFAS) were found in precipitation samples from Shenyang, demonstrating that wet deposition is one possible pathway for the removing of the selected PFAS chemicals from atmosphere. Major PFAS detected were PFOS (<0.38―51 ng/L), PFOA (0.82―13 ng/L) and PFHpA (0.76―11 ng/L), with their mean concentration of 5.4, 3.3 and 2.9 ng/L, respectively. Other PFSAs and PFCAs were detected at much lower frequency or below the limit of detection in all the samples. The work presented here offers some basis for the investigation on the environmental behavior and the evaluation of human exposure to PFAS. | LIU Wei DONG GuangHui JIN YiHe SASAKI Kazuaki SAITO Norimitsu SATO Itaru TSUDA Shuji NAKAYAMA Shoji F | 2009 | Chinese Science Bulletin2009,54,14: | 6 |
| 4 | 吸烟状况与急性缺血性脑卒中后功能结局的关系显示文摘吸烟是脑卒中的既定危险因素;然而,脑卒中前吸烟状态是否会影响急性缺血性脑卒中的临床预后尚不确定。该研究旨在阐明吸烟状态与急性缺血性脑卒中后功能预后的关系。研究者获取一项基于日本多中心医院的脑卒中登记资料,调查了2007年7-12月期间住院的10825例急性缺血性脑卒中患者,这些患者在脑卒中发作之前生活能够自理。吸烟状况分为从未吸烟者(不吸烟者),曾经吸烟者和现在吸烟者。临床结局包括3个月时功能转归不良(改良的Rankin量表评分≥2)和功能性依赖(改良的Rankin量表评分2~5)。 | 刘青(译) 刘莉(摘、审校) Matsuo R Ago T Kiyuna F Sato N Nakamura K Kuroda J Wakisaka Y Kitazono T | 2020 | 中华高血压杂志2020,28,2: | 4 |
| 5 | Helicobacter pylori infection and gastropathy:A comparison between Indonesian and Japanese patients显示文摘AIM:To compare the effects of Helicobacter pylori(H pylori) infection on gastropathy between Indonesian and Japanese patients.METHODS:Biopsy specimens were obtained during upper gastrointestinal endoscopy from 167 subjects(125 Indonesians and 42 Japanese) with uninvestigated symptoms of dyspepsia.The specimens were analyzed for the presence of H pylori using urease analysis,histopathology,and cell culture.The grade and activity of gastritis was assessed using the updated Sydney system.RESULTS:The percentages of Indonesian and Japanese patients who were H pylori-positive at the antrum or body of the stomach were similar(68% and 59.5%,respectively;P=0.316).Of those who were H pylori-positive,more Japanese patients than Indonesian patients had high levels of polymorphonuclear cells(P=0.001),mononuclear cells(P=0.013),glandular atrophy(P=0.000),and intestinal metaplasia(P=0.011) in both the antrum and body of the stomach.CONCLUSION:The grade of gastritis and prevalence of mucosal atrophy and intestinal metaplasia were higher in Japanese patients.The difference between Indonesian and Japanese patients was signifi cant. | Murdani Abdullah Hiroyuki Ohtsuka Abdul Aziz Rani Tadashi Sato Ari F Syam Masayuki A Fujino | 2009 | World Journal of Gastroenterology2009,15,39: | 2 |
| 6 | Plant pathogenesis-related proteins: molecular mechanisms of gene expression and protein function显示文摘 | Sato F | 1999 | J Biochem (Tokyo)1999,125,: | 1 |
| 7 | Activin type II receptor restoration in ACVR2-deficient colon cancer cells induces transfor- ming growth factor-beta response pathway genes显示文摘 | Deacu E Mori Y Sato F | 2004 | Cancer Res2004,64,21: | 1 |
| 8 | Expression of CD10/neutral endopeptidase in normal and malignant tissues of the human stomach and colon显示文摘 | Sato Y Itoh F Hinoda Y | 1996 | J Gastroenterol1996,31,1: | 1 |
| 9 | Recurrence patterns of oral leukoplakia after curative surgical resection: important factors that predict the risk of recurrence and malignancy显示文摘 | Kuribayashi Y Tsushima F Sato M | 2012 | J Oral Pathol Med2012,41,9: | 1 |
| 10 | Newly Diagnosed Acute Aortic Dissection Characteristices,Treatment Modifications and Outcomes 显示文摘 | Sato F Kitamura T Kongo M | 2005 | Tnt Heart J2005,6,6: | 1 |
| 11 | Cutting edge : endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression显示文摘 | Nomura F Akashi S Sakao Y Sato S Kawai T Matsumoto M | 2000 | J Immunol2000,104,7: | 1 |
| 12 | Antithrombotic effect of YM275466 ids separated from its effect on bleeding tome and coagulation time显示文摘 | Sato K Kaku SJ Hirayama F | 1998 | Eur J Pharmacol1998,352,1: | 1 |
| 13 | Early normal menstrual cycle pattern and the development of uterineleiomyomas显示文摘 | Sato F Miyake H Nishi M | 2000 | J Women Heath Gend Based Med2000,9,3: | 1 |
| 14 | Experimental stress-dilatancy relations of sand subjected to cyclic loading 显示文摘 | Pradhan T B S Tatsuoka F Sato Y | 1989 | Soils and Foundations1989,29,1: | 1 |
| 15 | ER-35786:carbapenam显示文摘 | Sato N Ohba F | 1996 | Drugs Future1996,21,4: | 1 |
| 16 | Lymph node micrometastasis and prog- nosis in patients with oesophageal squamous cell carcinoma显示文摘 | Sato F Shimada Y Li Z | 2001 | Br J Surg2001,88,3: | 1 |
| 17 | The miR-106b-25 polycistron,activated by genomic amplification,functions as an oncogene by suppressing p21 and Bim显示文摘 | Kan T Sato F Ito T | | 0,,05: | 1 |
| 18 | Flexible sheet with radiophotolu- minescence glass beads for remotely monitoring high beta - surface - contamination显示文摘 | Zushi N Sato F Kato Y | 2014 | Radiat Meas2014,71,: | 1 |
| 19 | Se-vere atrophic gastritis with Helicobacter pylori infection and gastri cancer显示文摘 | Kitahara F Shimazaki R Sato T | 1998 | Gastric Cancer1998,1,: | 1 |
| 20 | A new and practical synthesis of four possible stereoisomers of 3-(2-furyl)-3-hydroxy-2- methylpropionate 显示文摘 | Kusakabe M Sato F | 1989 | Journal of Organic Chemistry1989,54,14: | 1 |