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| 1 | A substitution mutation in OsPELOTA confers bacterial blight resistance by activating the salicylic acid pathway显示文摘We previously reported a spotted-leaf mutant pelota(originally termed HM_(47)) in rice displaying arrested growth and enhanced resistance to multiple races of Xanthomonas oryzae pv. oryzae. Here, we report the mapbased cloning of the causal gene OsPELOTA(originally termed spl^(HM47)). We identified a single base substitution from T to A at position 556 in the coding sequence of OsPELOTA, effectively mutating phenylalanine to isoleucine at position 186 in the translated protein sequence. Both functional complementation and over-expression could rescue the spotted-leaf phenotype. OsPELOTA, a paralogue to eukaryotic release factor 1(eRF_1), shows high sequence similarity to Drosophila Pelota and also localizes to the endoplasmic reticulum and plasma membrane.OsPELOTA is constitutively expressed in roots, leaves,sheaths, stems, and panicles. Elevated levels of salicylic acid and decreased level of jasmonate were detected in the pelota mutant. RNA-seq analysis confirmed that genes responding to salicylic acid were upregulated in the mutant. Our results indicate that the rice PELOTA protein is involved in bacterial leaf blight resistance by activating the salicylic acid metabolic pathway. | Xiao-Bo Zhang Bao-Hua Feng Hui-Mei Wang Xia Xu Yong-Feng Shi Yan He Zheng Chen Atul Prakash Sathe Lei Shi Jian-Li Wu | 2018 | Journal of Integrative Plant Biology2018，60，2： | 5 |
| 2 | The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting显示文摘 | Miriam Merad Priyanka Sathe Julie Helft Jennifer Miller Arthur Mortha | 2013 | Annual Review of Immunology2013，，： | 3 |
| 3 | Characterization of a Novel Gain-of-Function Spotted-Leaf Mutant with Enhanced Disease Resistance in Rice显示文摘We here reported the identification and characterization of a novel gain-of-function spotted-leaf 26 (Spl26) mutant from an ethylmethylsulfone (EMS)-induced rice cultivar IR64. Spl26 displayed reddish- brown lesions that firstly appeared on the leaf tips at the early tillering stage and spread gradually downward to cover the whole leaf blades that wilted subsequently. The lesion development was light- dependent under natural conditions. Spl26 exhibited impaired photosynthetic capacity with decreased chlorophyll content and lowered photosynthetic parameters which ultimately led to the poor performance of agronomic traits. Severe cell death occurred in Spl26 in accompany with increased malonaldehyde level and membrane ion leakage rate, elevated reactive oxygen species (ROS) accumulation, altered ROS scavenging activities, increased DNA fragmentation and decreased soluble protein levels. Defense responses were activated in Spl26 with enhanced resistance to rice bacterial blight, up-regulation of defense response genes and altered endogenous hormone levels. The spotted-leaf phenotype is controlled by a single dominant nuclear gene localized to a 305 kb region between RM5490 and InDel42 on the short arm of chromosome 7. The data suggested that Spl26 is a novel gain-of-function spotted-leaf mutant with enhanced bacterial disease resistance and immunity-associated premature leaf senescence and would provide the basis for cloning of the target gene. | CHEN Ting CHEN Zheng Atul Prakash SATHE ZHANG Zhihong LI Liangjian SHANG Huihui TANG Shaoqing ZHANG Xiaobo WU Jianli | 2019 | Rice science2019，26，6： | 3 |
| 4 | Fates and roles of alkali and alkaline earth metals during the pyrolysis of a Victorian brown coal显示文摘 | C.-Z. Li C. Sathe J.R. Kershaw Y. Pang | 1999 | Fuel1999，，： | 3 |
| 5 | The network of cytokines,receptors and transcription factors governing the development of dendritic cell subsets显示文摘The pathways leading to the development of different dendritic cell(DC)subsets have long been unclear.In recent years,a number of precursors on the route to DC development,both under steady state and inflammatory conditions,have been described,and the nature of these pathways is becoming clearer.In addition,the development of various knockout mouse models and an in vitro system modelling DC development have revealed the role of numerous cytokines and transcription factors that influence DC development.Here,we review recent findings on the factors important in DC development in the context of the developmental pathways that have been described. | Priyanka Sathe Li Wu | 2011 | Protein & Cell2011，2，8： | 3 |
| 6 | In Vitro Dissolution Profile Comparison—Statistics and Analysis of the Similarity Factor, f2显示文摘 | Vinod P. Shah Yi Tsong Pradeep Sathe Jen-Pei Liu | 1998 | Pharmaceutical Research1998，，6： | 2 |
| 7 | Multicentered prospective investigator initiated study to evaluate the clinical outcomes with extracorporeal cytokine adsorption device (CytoSorb®) in patients with sepsis and septic shock显示文摘BACKGROUND Sepsis is a severe clinical syndrome related to the host response to infection.The severity of infections is due to an activation cascade that will lead to an auto amplifying cytokine production:The cytokine storm.Hemoadsorption by CytoSorb®therapy is a new technology that helps to address the cytokine storm and to regain control over various inflammatory conditions.AIM To evaluate prospectively CytoSorb®therapy used as an adjunctive therapy along with standard of care in septic patients admitted to intensive care unit(ICU).METHODS This was a prospective,real time,investigator initiated,observational multicenter study conducted in patients admitted to the ICU with sepsis and septic shock.The improvement of mean arterial pressure and reduction of vasopressor needs were evaluated as primary outcome.The change in laboratory parameters,sepsis scores[acute physiology and chronic health evaluation(APACHE II)and sequential organ failure assessment(SOFA)]and vital parameters were considered as secondary outcome.The outcomes were also evaluated in the survivor and nonsurvivor group.Descriptive statistics were used;a P value<0.05 was considered RESULTS Overall,45 patients aged≥18 and≤80 years were included;the majority were men(n=31;69.0%),with mean age 47.16±14.11 years.Post CytoSorb®therapy,26 patients survived and 3 patients were lost to follow-up.In the survivor group,the percentage dose reduction in vasopressor was norepinephrine(51.4%),epinephrine(69.4%)and vasopressin(13.9%).A reduction in interleukin-6 levels(52.3%)was observed in the survivor group.Platelet count improved to 30.1%(P=0.2938),and total lung capacity count significantly reduced by 33%(P<0.0001).Serum creatinine and serum lactate were reduced by 33.3%(P=0.0190)and 39.4%(P=0.0120),respectively.The mean APACHE II score was 25.46±2.91 and SOFA scores was 12.90±4.02 before initiation of CytoSorb®therapy,and they were reduced significantly post therapy(APACHE II 20.1±2.47;P<0.0001 and SOFA 9.04±3.00;P=0.0003)in the survivor group.The predicted mortality in our patient population before CytoSorb®therapy was 56.5%,and it was reduced to 48.8%(actual mortality)after CytoSorb®therapy.We reported 75%survival rate in patients given treatment in<24 h of ICU admission and 68%survival rates in patients given treatment within 24-48 h of ICU admission.In the survivor group,the average number of days spent in the ICU was 4.44±1.66 d;while in the nonsurvivor group,the average number of days spent in ICU was 8.5±15.9 d.CytoSorb®therapy was safe and well tolerated with no adverse events reported.CONCLUSION CytoSorb®might be an effective adjuvant therapy in stabilizing sepsis and septic shock patients.However,it is advisable to start the therapy at an early stage(preferably within 24 h after onset of septic shock). | Rajib Paul Prachee Sathe Senthil Kumar Shiva Prasad Ma Aleem Prashant Sakhalvalkar | 2021 | World Journal of Critical Care Medicine2021，10，1： | 2 |
| 8 | Use of polymerase chain reaction for rapid detection of gene insertions in whole yeast cells显示文摘 | Sathe G M OBrien S Mclaughlin M M | 1991 | Nucleic Acids Res1991，19，： | 2 |
| 9 | In Vitro Dissolution Profile Comparison—Statistics and Analysis of the Similarity Factor, f2显示文摘 | Vinod P. Shah Yi Tsong Pradeep Sathe Jen-Pei Liu | 1998 | Pharmaceutical Research1998，，6： | 2 |
| 10 | Chemical formof selenium in soybean lection 显示文摘 | Sathe S K | 1992 | Agriculture and Food Chemistry1992，40，： | 1 |
| 11 | Effects of heating rate and ion-exchangeable cations on the pyrolysis yields from a Victorian brown coal显示文摘 | SATHE C PANG Y LI C-Z | 1999 | Energy Fuels1999，13，3： | 1 |
| 12 | Functional properties of the great northern bean proteins: emulsion, foaming, viscosity and gelation properties 显示文摘 | S K Sathe D K Salunkhe | 1981 | Journal of Food Science1981，46，： | 1 |
| 13 | Nitrogen bonding structure in carbon nitride thin films studied by soft x-ray spectroscopy 显示文摘 | Hellgren N Guo J Sathe C | 2001 | Appl Phys Lett2001，79，： | 1 |
| 14 | Chemical form of selenium in soybean lectin显示文摘 | Sathe S K Mason A C Rodibaugh R | 1992 | Journal of Agricultural and Food Chemistry1992，40，11： | 1 |
| 15 | Use of polymerase chain reaction for rapid detection of gene insertions in whole yeast cells显示文摘 | Sathe G M O'Brien S McLaughlin M M | 1991 | Nucl Acids Res1991，19，17： | 1 |
| 16 | Fates and roles of alkali and alkaline earth metals during the pyrolysis of a Victorian brown coal显示文摘 | LI C-Z SATHE C KERSHAW J R PANG Y | 2000 | Fuel2000，79，34： | 1 |
| 17 | Phytates in legumes and cereals显示文摘 | REDDY N L SATHE S K SALUNKHE D K | 1982 | Adv Food Bes1982，28，： | 1 |
| 18 | The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting 显示文摘 | Merad M Sathe P Helft J | 2013 | Annu Rev Immunol2013，31，5： | 1 |
| 19 | In vitro dissolution profile comparison-statistics and analysis of the similarity factors f2显示文摘 | SHAH V P TSONG Y SATHE P | 1998 | Pharm Res1998，15，6： | 1 |
| 20 | In vitro dissolution profile comparison statistics and analysis of the similarity factor f2显示文摘 | Shah VP Tsong Y Sathe P | 1998 | Pharm Res1998，15，6： | 1 |
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