|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 拉考沙胺添加治疗中国部分性癫■发作患者的疗效和安全性:一项随机双盲试验和开放标签扩展试验的亚组分析和事后分析显示文摘目的评估抗癫■药拉考沙胺添加治疗对控制不佳的部分性癫■发作成年患者的疗效和安全性。方法EP0008(NCT01710657)是一项为期24周在中国和日本16~70岁控制不佳的部分性癫■发作患者中开展的随机、双盲、安慰剂对照临床试验。在双盲试验中完成维持期的患者可进入开放标签扩展性试验EP0009(NCT01832038)。本研究针对两项试验中的中国536例部分性癫■发作患者进行分析,经剔除筛选失败的130例患者,共计406例中国部分性癫■发作患者入组,随机分为安慰剂组(136例)、拉考沙胺200 mg·d^-1组(136例)和拉考沙胺400 mg·d^-1组(134例)。结果406例中358例(88.2%)完成试验。从基线期至维持期,拉考沙胺400 mg·d^-1组和拉考沙胺200 mg·d^-1组每28 d癫■发作频次分别减少43.1%和33.6%,与安慰剂组比较,差异有显著统计学意义(P<0.001)。拉考沙胺400 mg·d^-1组、拉考沙胺200 mg·d^-1组、安慰剂组治疗期间发生率>10%的不良事件为头晕(分别为33.8%、14.7%、11.0%)和鼻咽炎(分别为11.3%、10.3%、8.8%)。同时联合使用钠离子通道阻滞剂(SCBs)患者的头晕发生率高于联合使用非SCBs患者。拉考沙胺联合使用SCBs时,滴定期患者的头晕发生率高于维持期。开放标签试验加量策略灵活,头晕发生率降低,患者的耐受性提高。结论拉考沙胺(200和400 mg·d^-1)用于中国控制不佳的部分性癫■发作患者有效,耐受性良好。 | 洪震 廖卫平 孟红梅 杜新鲁 Toru Osakabe Hiroshi Sasamoto Frank Tennigkeit 王文敏 王学峰 张黎明 周列民 张颖 | 2019 | 中国临床神经科学2019，27，4： | 3 |
| 2 | Preparation of fine particles of spinel-type Mn-Co-Ni oxide by freeze-drying显示文摘 | Torikai N Meguro T Sasamoto T | 1984 | Journal of the Chemical Society of Japan1984，6，： | 1 |
| 3 | Skin compatibility andecotoxicity of ethoxylated fatty methyl ester nonionics 显示文摘 | HAMA 1 SASAMOTO H TAMLRA T | 1998 | J SurfadDeterg1998，，： | 1 |
| 4 | Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation 显示文摘 | Nagasaka T Sasamoto H Notohara K | 2004 | J Clin Oncol2004，22，22： | 1 |
| 5 | Change in antibacterial characteristics with doping amountof ZnO in MgO-ZnO solid solution显示文摘 | Yamanoto O Sawai J Sasamoto T | 2000 | International Journal of Inorganic Materials2000，2，5： | 1 |
| 6 | Preparation ofcarbon material with SiC-concentration gradient by silicon im- pregnation and its oxidation behaviour显示文摘 | Yamamoto O Imai K Sasamoto T | 1993 | Journal of the Eu- ropean Ceramic Society1993，12，6： | 1 |
| 7 | Skin compatibility and ecotoxicity of ethoxylated fatty methyl ester nonionics显示文摘 | HAMA I SASAMOTO H TAMURA T | 1998 | Journal of Surfactants and Detergents1998，1，1： | 1 |
| 8 | Skin compatibility and ecotoxicity of ethoxy- lated fatty methyl ester nonionics显示文摘 | HAMA I SASAMOTO H | 1998 | Journal of Surfactants and Deter- gents1998，1，： | 1 |
| 9 | Statistical Mechanics of an NP-Complete Problem:Subset Sum显示文摘 | SASAMOTO T TOYOIZUMI T | | 0，，： | 1 |
| 10 | Alexithymia and reduced white matter integrity in schizophrenia a diffusion tensor imaging study on impaired emotional self-awareness显示文摘 | Kubota M Miyata J Sasamoto A | 2012 | Schizophr Res2012，141，23： | 1 |
| 11 | Influence of catalyst structure on direct ethoxylation of fatty methyl esters over Al-Mg composite oxide catalyst 显示文摘 | HAMA I SASAMOTO H OKAMOTO T | 1997 | JAOCS1997，74，： | 1 |
| 12 | 显示文摘 | SASAMOTO H MAEDA M TSUJI A | 1995 | Anal Chim Acta1995，309，13： | 1 |
| 13 | Connectivity analyses of white matters in schizophrenia显示文摘 | Sasamoto A Miyata J Kubota M | 2013 | Seishin Shinkeigaku Zasshi2013，115，8： | 1 |
| 14 | Preparation of carbon material with SiC-concentration gradient by silicon impregnation and oxida- tion behaviour显示文摘 | Yamamoto O Imai K Sasamoto T | 1993 | Journal of the European Ceramic Society1993，12，6： | 1 |
| 15 | Activated carbon sphere with antibacterial characteristics 显示文摘 | Yamamoto O Sawai J Sasamoto T | 2002 | Materials Transactions2002，43，5： | 1 |
| 16 | Prolonged survival of reconstitutel skin grafts without smmunosuppression显示文摘 | Sasamoto Y Alexander JW Babcock GF | 1990 | J Burn Care Rehabil1990，11，： | 1 |
| 17 | Statistical Mechanics of an NP-Complete Problem: Subset Sum显示文摘 | Sasamoto T Toyoizumi T | 2003 | Journal of Physics A: Mathematical and General2003，，10： | 1 |
| 18 | Diversity of Lactic Acid Bacteria and Yeasts in Airag and Tarag,Traditional Fermented Milk Products of Mongolia显示文摘 | Watanabe K Fujimoto J Sasamoto M | 2008 | World J Microbiol Biotechnol2008，24，： | 1 |
| 19 | Complete genomic sequence of the genome of the filamentous nitrogen-fixing cyanobacerium Anabaena sp.strain PCC 7120显示文摘 | Kaneko T Nakamura Y Wolk C P Kuritz T, Sasamoto S, Watanabe A, Iriguchi M, Ishikawa A, Kawashima K, Kimura T, Kishida Y, Kohara M, Matsumoto M, Matsuno A, Muraki A, Nakazaki N, Shimpo S, Sugimoto M, Takazawa M, Yamada M, Yasuda M, Tabata S | | 0，，： | 1 |
| 20 | Estimation of 1999-2004 dietary daily intake of PCDDs, PCDFs and dioxinlike PCBs by a total diet study in metropolitan Tokyo, Japan 显示文摘 | SASAMOTO T USHIO F KIKUTANI N | 2006 | Chemosphere2006，64，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员