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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Preoperative left ventricular systolic dysfunction correlates with the adverse postoperative consequences of annular-papilary disconnection in the course of mitral valve replacement for stenosi显示文摘 | Essop MR Kontozis Sareli P | 1998 | J Heart Valve Dis1998，7，4： | 1 |
| 3 | The effect of heat treatment on the abrasion resistance of alloy white irons显示文摘 | Tabrett C P Sare I R | 1997 | Wear1997，，： | 1 |
| 4 | The effect of heat treatment on the abrasion resistance of alloy white iron显示文摘 | Tabrett C P Sare I R | 1997 | Wear1997，，： | 1 |
| 5 | Preoperative left ventricular systolic dysfunction correlates with the adverse postoperative consequences of annular papillary disconnection in the course of mitral valve replacement for stenosis显示文摘 | Essop MR Kontozis L Sareli P | 1998 | J Heart Valve Dis1998，7，4： | 1 |
| 6 | Effect of high temperature and sub-ambient treatment on the matrix structure and abrasion resistance of a high-chromium white iron显示文摘 | Tabrett C P Sare I R | 1998 | Scripta Mater1998，38，12： | 1 |
| 7 | Effect of heat treatment on the abrasion resistance of alloy white irons显示文摘 | Tabrett C P and Sare I R | 1997 | Wear1997，，： | 1 |
| 8 | Obstruction of mechanical heart valve prostheses:Clinical aspects and surgical management显示文摘 | SARELI P WISENBAUGH T | 1991 | J Am Coll Cardiol1991，17，3： | 1 |
| 9 | Microstructure-property relationships in high chromium white iron alloys显示文摘 | Tabrett C P Sare I R Ghomashchi M R | 1996 | International Materials Reviews1996，41，2： | 1 |
| 10 | Co-precipitation of copper and nickel in crystalline silicon 显示文摘 | RUDOLF C SARING P STOLZE L | 2009 | Mater Sci Eng B2009，，11： | 1 |
| 11 | Effect of high temperature and sub-ambient treatments on the matrix structure and abrasion resistance of a high-chromium white iron 显示文摘 | TABRETT C P SARE I R | 1998 | Scripta Materialia1998，，38： | 1 |
| 12 | Microstructure-property relationship in high chromium white iron alloys显示文摘 | Tabrett C P Sare I R Ghomashchi M R | 1996 | International Materials Reviews1996，41，： | 1 |
| 13 | Efficacy of mitral balloon valvotomy in reducing the severity of associated tricuspid valve regurgitation显示文摘 | Essop MR Sareli P | 1994 | Am J Cardiol1994，73，2： | 1 |
| 14 | Microstructureproperty relationships in high chromium white iron alloys显示文摘 | Tabrett C P Sare I R Ghomashchi M R | 1996 | International Materials Reviews1996，41，2： | 1 |
| 15 | Microstructure-property relationship in high chromium white iron alloys显示文摘 | Tabrett C P Sare I R Ghomashchi M R | | 0，，41： | 1 |
| 16 | Left ventricular diventricular and aneurysms:congenital and acquird lesions显示文摘 | Bales AC Saldenski J Sareli P | 1998 | Echocardiography1998，1，1： | 1 |
| 17 | The effect of heat treatment on the abrasion resistance of alloy white irons 显示文摘 | Tabrett C P Sare I R | 1997 | Wear1997，，： | 1 |
| 18 | Microstructure-property relationship in high chromium white iron alloys显示文摘 | TABRETT C P,SARE I R,GHOMASHCHI M R | 1996 | International Materials Review1996，41，2： | 1 |
| 19 | Preoperative left ventricular systolic dyfunction correlates with the adverse postoperative consequences of annular-papillary disconnection in the course of mitral valve replacement for stenosis显示文摘 | Essop Mr Kontozis L Sareli P | 1998 | Heart Valve Dis1998，7，4： | 1 |
| 20 | Effect of heat treatment on the abra- sion resistance of alloy white iron显示文摘 | Tabrett C P Sare I R | 1997 | Wear1997，12，5： | 1 |
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