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| 1 | Dual color optogenetic control of neural populations using low-noise,multishank optoelectrodes显示文摘Optogenetics allows for optical manipulation of neuronal activity and has been increasingly combined with intracellular and extracellular electrophysiological recordings.Genetically-identified classes of neurons are optically manipulated,though the versatility of optogenetics would be increased if independent control of distinct neural populations could be achieved on a sufficient spatial and temporal resolution.We report a scalable multisite optoelectrode design that allows simultaneous optogenetic control of two spatially intermingled neuronal populations in vivo.We describe the design,fabrication,and assembly of low-noise,multisite/multicolor optoelectrodes.Each shank of the four-shank assembly is monolithically integrated with 8 recording sites and a dualcolor waveguide mixer with a 7×30μm cross-section,coupled to 405 nm and 635 nm injection laser diodes(ILDs)via gradient-index(GRIN)lenses to meet optical and thermal design requirements.To better understand noise on the recording channels generated during diode-based activation,we developed a lumped-circuit modeling approach for EMI coupling mechanisms and used it to limit artifacts to amplitudes under 100μV upto an optical output power of 450μW.We implanted the packaged devices into the CA1 pyramidal layer of awake mice,expressing Channelrhodopsin-2 in pyramidal cells and ChrimsonR in paravalbumin-expressing interneurons,and achieved optical excitation of each cell type using sub-mW illumination.We highlight the potential use of this technology for functional dissection of neural circuits. | Komal Kampasi Daniel F.English John Seymour Eran Stark Sam McKenzie Mihály Vöröslakos György Buzsáki Kensall D.Wise Euisik Yoon | 2018 | Microsystems & Nanoengineering2018，4，1： | 8 |
| 2 | Prosthetic above-knee femoropopliteal bypass grafting: Five-year results of a randomized trial显示文摘 | Richard M Green William M Abbott Teruo Matsumoto Jock R Wheeler Normand Miller Frank J Veith Sam Money H Edward Garrett | 2000 | Journal of Vascular Surgery2000，，： | 2 |
| 3 | Demand for hospital emergency departments:a conceptual understanding显示文摘BACKGROUND: Emergency departments (EDs) are critical to the management of acute illnessand injury, and the provision of health system access. However, EDs have become increasinglycongested due to increased demand, increased complexity of care and blocked access to ongoingcare (access block). Congestion has clinical and organisational implications. This paper aims todescribe the factors that appear to infl uence demand for ED services, and their interrelationships asthe basis for further research into the role of private hospital EDs.DATA SOURCES: Multiple databases (PubMed, ProQuest, Academic Search Elite and ScienceDirect) and relevant journals were searched using terms related to EDs and emergency health needs.Literature pertaining to emergency department utilisation worldwide was identified, and articlesselected for further examination on the basis of their relevance and signifi cance to ED demand.RESULTS: Factors influencing ED demand can be categorized into those describing thehealth needs of the patients, those predisposing a patient to seeking help, and those relating topolicy factors such as provision of services and insurance status. This paper describes the factorsinfl uencing ED presentations, and proposes a novel conceptual map of their interrelationship.CONCLUSION: This review has explored the factors contributing to the growing demand forED care, the infl uence these factors have on ED demand, and their interrelationships depicted in theconceptual model. | Jun He Xiang-yu Hou Sam Toloo Jennifer R Patrick Gerry Fitz Gerald | 2011 | World Journal of Emergency Medicine2011，2，4： | 2 |
| 4 | Quantitative trait loci controlling sulfur containing amino acids,methionine and cysteine,in soybean seeds显示文摘 | Panthee D R Pantalone V R Sams C E | 2006 | Theoretical and Applied Genetics2006，112，： | 1 |
| 5 | Seed quality QTL in a prominent soybean population显示文摘 | Hyten D L Pantalone V R Sams C E | 2004 | Theor App Genet2004，109，： | 1 |
| 6 | Heuristic approaches to vehicle routing with backhauls and time windows显示文摘 | Sam R T Jean Y P Tong S | 1996 | Computers and Operations Research1996，23，11： | 1 |
| 7 | Coaxial and waveguide microcalorimeters for RF and microwave power standards显示文摘 | Nak Sam Chung Joon Shin H Bayer R Honigbaum | 1989 | IEEE Trans1989，38，2： | 1 |
| 8 | Nonlinear dimensionalityreduction by locally linear embedding 显示文摘 | Sam T R Lawrence K S | 2000 | Science2000，290，22： | 1 |
| 9 | Nonlinear dimensionality reduction by locally linear embedding显示文摘 | Sam T R Lawrence K S | 2000 | Science2000，290，5000： | 1 |
| 10 | A case for using plethodontid salamanders for monitoring biodiversity and ecosystem integrity of North American forests显示文摘 | WELSH J R SAM D | 2002 | Conserration Biology2002，15，： | 1 |
| 11 | Quantitative trait loci controlling sulfur contsining amino acids,methionine and cysteine,in soybean seeds显示文摘 | Panthee D R Pantalone V R Sams C E | 2005 | Theor App Genet2005，112，： | 1 |
| 12 | Local and remote matrix responses to chondrocyte-laden collagen scaffold implantation in extensive articular cartilage defects显示文摘 | SAMS AE MINOE R WOOTTON JA | 1995 | Osteoarthritis Cartilage1995，3，1： | 1 |
| 13 | The effect of seasonal heat stress on rigor development and the incidence of pale, exudative turkey meat 显示文摘 | Mckee S R Sams A R | 1997 | Poultry Sci1997，76，： | 1 |
| 14 | A class of proportional in tegral sliding mode control with application to active suspension system显示文摘 | Sam Y M Osman H S Ghani M R | 2004 | Systems & Control Letters2004，51，3： | 1 |
| 15 | U/Pb zircon, strontium, and oxygen isotopic and geochronological study of the southernmost Sierra Nevada batholith, California显示文摘 | Saleeby J B Sams D B Kisder R W | 1987 | Journal of Geophysical Research1987，92，10： | 1 |
| 16 | Population pharmacokineties of remifentanil in infants and children undergoing cardiac surgery显示文摘 | SAM W J HAMMER G B DROVER D R | 2009 | BMC Anesthesiol2009，9，： | 1 |
| 17 | Heat Transfer to the Combustion Chamber and Port Walls of IC Engines-measurement and Prediction显示文摘 | WIMMER A PIVEC R SAMS T | 2000 | SAE2000，，： | 1 |
| 18 | Quantitative trait loci for β-conglycinin (7S) and glycinin (11S) fractions of soybean storage protein显示文摘 | Panthee D R Kwanyuen P Sams C E | 2004 | Journal of the American Oil Chemists'' Society2004，81，： | 1 |
| 19 | The Job Stress-Job Per- formance Relationship in the Social Service Encounters 显示文摘 | Cano C R Sams D Schwartz J | 2009 | Intemational Journal of Nonprofit and Voluntary Sector Marketing2009，，1： | 1 |
| 20 | The selective estrogen receptor modulator, raloxifene: a segment Ⅱ/Ⅲ delivery study in rats 显示文摘 | Buelke - Sam Judy Cohen Ilene R Wierda Daniel | 1998 | Reproductive Toxicology1998，12，3： | 1 |
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