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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Exploring the richness of the stimulus显示文摘 | Sampson G | | 0，，： | 1 |
| 3 | Photonic codedivision multiple-access communications显示文摘 | Sampson D D Pendock G J Griffin R A | 1997 | Fiber and Integrated Optics1997，16，： | 1 |
| 4 | Paraoxonase-1 (PON-1) genotype and activity and in vivo oxidized plasma low-density lipopr-otein in Type II diabetes显示文摘 | Sampson MJ Braschi S Willis G | 2005 | Clin Sci2005，109，2： | 1 |
| 5 | Prediction of dental arch development: an assessment of Pont′s index in three human populations显示文摘 | Dalidjan M Sampson W Townsend G | 1995 | Am J Orthod Dentofacial Orthop1995，107，5： | 1 |
| 6 | A successive approximation vector quantizer for wavelet transform image coding显示文摘 | da Silva E A B Sampson D G Ghanbari M | 1997 | IEEE Trans on Image Processing1997，5，2： | 1 |
| 7 | Connective tissue growth factor is a biomarker and mediator ofkidney allograft fibrosis显示文摘 | Cheng O Thuillier R Sampson E Schultz G Ruiz P Zhang X etal | 2006 | Am J Transplant2006，406，： | 1 |
| 8 | Tracking the rapid pace of GIS-related capabilities and their accessibility显示文摘 | SAMPSON B A DELGIUDICE G D | 2006 | Wildlife Society Bulletin2006，34，5： | 1 |
| 9 | Determination of postmortem interval by sampling vitreous humour显示文摘 | James R A Hoadley P A Sampson B G | 1997 | Am J Forensic Med Pathol1997，18，2： | 1 |
| 10 | Paraoxonase-1 (PON-1) genotype and activity and in vivo oxidized plasma low-density lipoprotein in Type Ⅱ diabetes 显示文摘 | Sampson MJ Braschi S Willis G Astley SB | 2005 | Clin Sci (Lond)2005，109，2： | 1 |
| 11 | Hy- per-spectr,M remote sensing of forest condition : Estimating chloro- phyll content in tolerant hardwotsts显示文摘 | Sampson P H Zarco-tejada P J Mohammed G H | 2003 | Forest Scienee2003，49，3： | 1 |
| 12 | The Concise Cambridge History of English Literature 显示文摘 | Sampson G | 1982 | Cambridge: Cambridge University Press1982，，： | 1 |
| 13 | Exploring therichness of the stimulus 显示文摘 | Sampson G | 2002 | The Linguistic Review2002，，19： | 1 |
| 14 | Prediction of arch development: assessment of pont' s index in three human populatioia显示文摘 | Dalidgan M Sampson W Townsend G | 1995 | Am J Orthod Dentofacial Orthop1995，107，5： | 1 |
| 15 | Vegetation stress detection through chlorophyll a + b estimation and fluorescence effects on hyperspectral imagery显示文摘 | Zarco-Tejada P J Miller J R Mohammed G H Noland T L Sampson P H | | 0，，05： | 1 |
| 16 | TGF beta stimula-ted re-epithelialisation is regulated by CTGF and Ras/MEK/ERK signaling显示文摘 | Seeker G A Shortt A J Sampson Et | 2008 | Exp Cell Res2008，314，1： | 1 |
| 17 | Liposome-delivered superoxide dismutase prevents nitric oxide-dependent motor neuron death induced by trophic factor withdrawal显示文摘 | ESTEVEZ A G SAMPSON J B ZHUANG Y X | 2000 | Free Radic Biol Med2000，28，3： | 1 |
| 18 | Simvastatin inhibits growth factor expression and modulates profibrogenic markers in lung fibroblasts显示文摘 | WATTS K L SAMPSON E M SCHULTZ G S | 2005 | Am J Respir Cell Mol Biol2005，32，4： | 1 |
| 19 | Isolation of cloned Moloney murine leukemia virus reverse transcriptase lacking ribonuclease H activity显示文摘 | KOTEWICZ M L SAMPSON C M DALESSIO J M GERARD G F | 1988 | Nucleic Acids Res1988，16，1： | 1 |
| 20 | Bistetrachloroferrate tetrafluoroborate显示文摘 | Lewis G R Hubberstey P Sampson C L | 2002 | Acta Cryst2002，58，： | 1 |
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