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| 1 | On-chip micro-electromagnets for magnetic-based bio-molecules separation 显示文摘 | SAMPER V POENAR D | 2004 | Journal of Magnetism and Magnetic Materials2004，281，23： | 1 |
| 2 | Fabrication of a gecko-like hierarchical fibril array using a bonded porous a- lumina template显示文摘 | KUSTANDI T S SAMPER V D NG W S | 2007 | Journal of Micromechanies and Microengi- neering2007，17，10： | 1 |
| 3 | Are Women More Empathetic than Men? A Longitudinal Study in Adolescence显示文摘 | Mestre M V Samper P Frias M D Tur A M | 2009 | The Spanish Journal of Psychology2009，12，1： | 1 |
| 4 | Multistator LIGA-fabricated electrostatic wobble motors with integrated synchronous control 显示文摘 | Samper V D Sangster A J | 1995 | Journal of Microelectromechanical Systems1995，7，2： | 1 |
| 5 | Mierofluidic systems for extracting nucleic acids for DNA and RNA analysis 显示文摘 | Hui W C Yobas L Samper V D | 2007 | Sensots and Actuators A2007，133，2： | 1 |
| 6 | Thermal and mechanical characterization of epoxy resins (ELO and ESO) cured with anhydrides显示文摘 | Samper M D Fombuena V Boronat T | 2012 | Journal of the American Oil Chemists''Society2012，89，： | 1 |
| 7 | Polymorphism AGT2(rs4762)is involved in the development of dermatologic events:Proof-of-concept in hepatocellular carcinoma patients treated with sorafenib显示文摘BACKGROUND Dermatologic adverse events(DAEs)are associated with a better outcome in patients with hepatocellular carcinoma(HCC)irrespective of the therapeutic agent received.The exact mechanisms associated with the development of DAEs are unknown although several studies point to direct toxicity of tyrosine kinase inhibitors(TKIs)to the skin or an immune-mediated reaction triggered by the oncologic treatment.As is the case in other conditions,individual genetic variants may partially explain a higher risk of DAEs.AIM To evaluate the contribution of several gene variants to the risk of developing DAEs in HCC patients treated with TKIs.METHODS We first analyzed 27 single-nucleotide polymorphisms(SNPs)from 12 genes selected as potential predictors of adverse event(AE)development in HCC patients treated with sorafenib[Barcelona Clinic Liver Cancer 1(BCLC1)cohort].Three additional cohorts were analyzed for AGT1(rs699)and AGT2(rs4762)polymorphisms-initially identified as predictors of DAEs:BCLC2(n=79),Northern Italy(n=221)and Naples(n=69)cohorts,respectively.The relation between SNPs and DAEs and death were assessed by univariate and multivariate Cox regression models,and presented with hazard ratios and their 95%confidence intervals(95%CI).RESULTS The BCLC1 cohort showed that patients with arterial hypertension(AHT)(HR=1.61;P value=0.007)and/or AGT SNPs had an increased risk of DAEs.Thereafter,AGT2(rs4762)AA genotype was found to be linked to a statistically significant increased probability of DAEs(HR=5.97;P value=0.0201,AA vs GG)in the Northern Italy cohort by multivariate analysis adjusted for BCLC stage,ECOG-PS,diabetes and AHT.The value of this genetic marker was externally validated in the cohort combining the BCLC1,BCLC2 and Naples cohorts[HR=3.12(95%CI:1.2-8.14),P value=0.0199,AGT2(rs4762)AA vs AG genotype and HR=2.73(95%CI:1.18-6.32)P value=0.0188,AGT2(rs4762)AA vs GG genotype].None of the other gene variants tested were found to be associated with the risk of DAE development.CONCLUSION DAE development in HCC patients receiving TKIs could be explained by the AGT2(rs4762)gene variant.If validated in other anti-oncogenic treatments,it might be considered a good prognosis marker. | Víctor Sapena Massimo Iavarone Loreto Boix Floriana Facchetti Maria Guarino Marco Sanduzzi Zamparelli Alessandro Granito Esther Samper Mario Scartozzi Josep Corominas Giorgia Marisi Alba Díaz Andrea Casadei-Gardini Laura Gramantieri Pietro Lampertico Filomena Morisco Ferran Torres Jordi Bruix María Reig | 2022 | World Journal of Hepatology2022，14，7： | 0 |
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