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| 1 | Updates in the pathophysiological mechanisms of Parkinson's disease: Emerging role of bone marrow mesenchymal stem cells显示文摘AIM: To explore the approaches exerted by mesenchymal stem cells(MSCs) to improve Parkinson's disease(PD) pathophysiology.METHODS: MSCs were harvested from bone marrowof femoral bones of male rats, grown and propagated in culture. Twenty four ovariectomized animals were classified into 3 groups: Group(1) was control, Groups(2) and(3) were subcutaneously administered with rotenone for 14 d after one month of ovariectomy for induction of PD. Then, Group(2) was left untreated, while Group(3) was treated with single intravenous dose of bone marrow derived MSCs(BM-MSCs). SRY gene was assessed by PCR in brain tissue of the female rats. Serum transforming growth factor beta-1(TGF-β1), monocyte chemoattractant protein-1(MCP-1) and brain derived neurotrophic factor(BDNF) levels were assayed by ELISA. Brain dopamine DA level was assayed fluorometrically, while brain tyrosine hydroxylase(TH) and nestin gene expression were detected by semi-quantitative real time PCR. Brain survivin expression was determined by immunohistochemical procedure. Histopathological investigation of brain tissues was also done.RESULTS: BM-MSCs were able to home at the injured brains and elicited significant decrease in serum TGF-β1(489.7 ± 13.0 vs 691.2 ± 8.0, P < 0.05) and MCP-1(89.6 ± 2.0 vs 112.1 ± 1.9, P < 0.05) levels associated with significant increase in serum BDNF(3663 ± 17.8 vs 2905 ± 72.9, P < 0.05) and brain DA(874 ± 15.0 vs 599 ± 9.8, P < 0.05) levels as well as brain TH(1.18 ± 0.004 vs 0.54 ± 0.009, P < 0.05) and nestin(1.29 ± 0.005 vs 0.67 ± 0.006, P < 0.05) genes expression levels. In addition to, producing insignificant increase in the number of positive cells for survivin(293.2 ± 15.9 vs 271.5 ± 15.9, P > 0.05) expression. Finally, the brain sections showed intact histological structure of the striatum as a result of treatment with BM-MSCs. CONCLUSION: The current study sheds light on the therapeutic potential of BM-MSCs against PD pathophysiology via multi-mechanistic actions. | Hanaa H Ahmed Ahmed M Salem Hazem M Atta Emad F Eskandar Abdel Razik H Farrag Mohamed A Ghazy Neveen A Salem Hadeer A Aglan | 2016 | World Journal of Stem Cells2016，8，3： | 9 |
| 2 | Efficacy and safety of treatment of hepatitis C virus infection in renal transplant recipients显示文摘AIM: To assess the efficacy and safety of combinedpegylated interferon and ribavirin therapy in hepatitis C virus (HCV) infection in renal transplant recipients. METHODS: This is a retrospective chart review of post renal transplant patients who were positive for anti-HCV and HCV-RNA, and who have received treatment with combination of pegylated interferon and ribavirin between October 2003 and December 2008. Only patients with stable graft function and absence of evidence of cirrhosis and who received the therapy for continuous 48 wk were included. Nineteen patients (13 male and 6 female) were identified and included. The patient's complete blood count, liver and kidney prof ile, and cal- culated glomerular f iltration rate (GFR) were monitored every 6-8 wk while on treatment. HCV-RNA was tested at 12 wk for early virological response, at 48 wk for end of treatment response (ETR), and then retested at 24, and 48 wk after completion of therapy for sustained virological response (SVR). Liver biopsies were obtained before treatment from all patients and graft kidney biopsies were performed as required. RESULTS: Of the entire cohort, 9 patients (47.4%) showed an ETR and 8 had SVR (42.1%). Of the 8 patients with abnormal alanine aminotransferase (ALT) levels at baseline, 78.9% had their ALT normalized (including the virological non responders). ALT was normal in all responders at the end of therapy and at 24 wk post therapy (100%). Only one patient (5.3%) developed an increase in creatinine and decline in GFR from baseline towards the end of treatment. This patient's kidney biopsy revealed borderline rejection. There was no impact on response by HCV-genotype, initial HCV RNA load, age or sex of the patient or duration post transplant before commencement of therapy. All patients tolerated treatment in the same way as non-transplant with no unusual or increased occurrence of side effects. CONCLUSION: The combination of pegylated interferon and ribavirin is effective in suppressing HCV-RNA,with a low risk of graft rejection or failure in HCV infected renal transplant recipients. | Abdulrahman A Aljumah Mohamed A Saeed Ahmed I Al Flaiw Ibrahim H Al Traif Abduljaleel M Al Alwan Salem H Al Qurashi Ghormallah A Al Ghamdi Fayez F Al Hejaili Mohammed A Al Balwi Abdulla A Al Sayyari | 2012 | World Journal of Gastroenterology2012，18，1： | 2 |
| 3 | Sagas显示文摘 | Garcia H M Salem K | 1987 | ACM SIGMOD Record1987，16，3： | 1 |
| 4 | CW Nd:YAG laser cutting of ultra low carbon steel thin sheets using 02 assist gas 显示文摘 | H G Salem M S Mansour Y Badr | 2008 | Journal of Materials Processing Technology2008，196，1： | 1 |
| 5 | Full-scale application of the BABE technology显示文摘 | Salem S Berends D van der Roest H | | 0，，07： | 1 |
| 6 | Developing a high performance superoxide dismutase based electrochemical biosensor for radiation dosimetry of thallium 201显示文摘 | Salem F Tavakoli H Sadeghi M | 2014 | Radiat Phys Chem2014，102，： | 1 |
| 7 | A prospective randomized study comparing shock wave lithotripsy and semirigid ureteroscopy for the management of proximal ureteral calculi 显示文摘 | SALEM H K | 2009 | Urology2009，74，： | 1 |
| 8 | Electrical properties and structural changes of thermally co-evaporated CuInSe films显示文摘 | Moharram A H Hafiz M M Salem A | 2001 | Applied Surface Science2001，172，： | 1 |
| 9 | Main memory database systems:An Overview 显示文摘 | GARCIA-MOLINA H SALEM K | 1992 | IEEE Transactions on Knowledge and Data Engineering1992，4，6： | 1 |
| 10 | Diagenesis and reservoir quality evolution of palaeocene deep-water,marine sandstones,the Shetland-Faroes Basin,British continental shelf显示文摘 | Mansurbeg H Morad S Salem A Marfil R El-ghali M A K Nystuen J P Caja M A Amorosi A Garcia D A Iglesia La | 2008 | Marine and Petroleum Geology2008，25，： | 1 |
| 11 | The effects of diclofenac on cryo-indueed miosis 显示文摘 | al Salem M Hadidi H Alwash R | 1996 | Int Ophthalmol1996，20，： | 1 |
| 12 | Diagenesis and reservoir quality evolution of palaeocene deep-water,marine sandstones, the Shetland-Faroes Basin,British continental shelf显示文摘 | Mansurbeg H Morad S Salem A | 2008 | Marine and Petroleum Geology2008，25，6： | 1 |
| 13 | Mainmemory database systems : An overview 显示文摘 | GARCIA-MOLINA H SALEM K | 1992 | IEEE Transactions on Knowledge and Engineering1992，4，6： | 1 |
| 14 | Pharmacological preconditioning with nicorandil and pioglitazone attenuates myocardial ischemia/reperfusion injury in rats显示文摘 | AHMED L A SALEM H A ATTIA A S | 2011 | Eur J Pharmacol2011，663，13： | 1 |
| 15 | Separation of lipid classes by solid phase extrac-tion显示文摘 | Kim H Y Salem N | 1990 | Journal of lipid research1990，31，12： | 1 |
| 16 | On the fractional order m-point boundary value problem in reflexive Banach spaces and weak topologies 显示文摘 | SALEM H A H | 2009 | Journal of Computational and Applied Mathematics2009，224，2： | 1 |
| 17 | Silicoproteinosis: a specific clinical and radiological entity显示文摘 | Racil H Ben Salem N Chaouch N | 2012 | Revue des maladies respiratoires2012，29，9： | 1 |
| 18 | Main memory database systems: an overview显示文摘 | Gareia-Molina H Salem K | 1992 | IEEE Transactions on Knowledge and Data Engineering1992，4，6： | 1 |
| 19 | Main memory database systems: an overview显示文摘 | Garcia-Molina H Salem K | 1992 | Knowledge and Data Engineering IEEE Trans- actions1992，4，6： | 1 |
| 20 | Crocin prevents patulininduced acute toxicity in cardiac tissues via the regulation of oxidative damage and apoptosis显示文摘 | Boussabbeh M Ben Salem I Neffati F Naj ar MF Bacha H Abid-Essefi S | 2015 | J Biochem Mol Toxicol2015，29，10： | 1 |
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