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| 1 | MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth显示文摘一幅 microRNA 表示屏幕被执行从良性的 melanocytic nevi 在 laser-microdissected 纸巾分析 157 不同 microRNAs (n = 10 ) 并且主要恶意的黑瘤(n = 10 ) ,用量的即时 PCR。微分表示被作出对有利的裁决 72 microRNAs。microRNAs 的 let-7 家庭的成员是显著地, down 作为与良性的 nevi 相比在主要黑瘤调整了,为是的这些分子的一个可能的角色暗示肿瘤在恶意的黑瘤压制 ors。有趣地,类似的调查结果为肺和结肠癌被描述了。在黑瘤房间试管内 down 的 let-7b 的 Overexpression 调整了 cyclins 的表示 D1, D3,和 A,和 cyclin 依赖的 kinase (Cdk ) 4,所有哪个被描述了在黑瘤开发起一个作用。蛋白质表示上的 let-7b 的效果由于单个 mRNAs 的 3'-untranslated 区域(3'UTRs ) 指向,为 cyclin D1 由记者基因分析例示。与它细胞周期管理者上的 down modulating 效果一致, let-7b 禁止了细胞周期前进和黑瘤细胞的抛锚无关的生长。总起来说,这些调查结果不仅指向早黑瘤开发的新规章的机制,而且可以打开大街因为未来指向了这个肿瘤的治疗。 | Julia Schultz Peter Lorenz Gerd Gross Saleh Ibrahim Manfred Kunz | 2008 | Cell Research2008，18，5： | 45 |
| 2 | 氧化应激检测在男性不育临床中的应用显示文摘活性氧 (ROS)在低浓度发生可以调节正常精子功能 ,而高浓度ROS危害精子的存活力和功能。ROS产生过量与抗氧化系统损伤会发生氧化应激 (OS)。目前认为损伤OS促进了一系列男性生殖功能的病理学改变。ROS介导的精子质膜过氧化损伤 ,可以解释在高比例的不育病人中观察到的精子功能缺陷。ROS产生过多也会破坏精子核内DNA的完整性。DNA碱基对OS敏感 ,这些结构的过氧化能引起碱基修饰、DNA链断裂以及染色质交联。由过量ROS诱发的DNA损伤会加速生殖细胞凋亡过程 ,导致与男性不育相关的精子计数降低 ,以及可以解释近半个世纪以来所观察到的精液质量明显下降现象。近 10年来 ,克里夫兰临床基金会的研究组已经查明了男性不育中OS的关键作用 ;研究的主要目的是将这些重要的知识从实验室转向临床应用。我们设计的研究目标 :①理解精液中OS发生的精确机制 ;②建立准确评估OS状态的实验 ,并进行质控研究 ;③检测OS与精子核DNA损伤之间的相关性 ; | Ashok Agarwal Ramadan Abdou Saleh | 2002 | 中华男科学杂志2002，8，1： | 26 |
| 3 | Exact solutions for nonlinear partial fractional differential equations显示文摘In this article,we use the fractional complex transformation to convert nonlinear partial fractional differential equations to nonlinear ordinary differential equations.We use the improved(G'/G)-expansion function method to calculate the exact solutions to the time-and space-fractional derivative foam drainage equation and the time-and space-fractional derivative nonlinear KdV equation.This method is efficient and powerful for solving wide classes of nonlinear evolution fractional order equations. | Khaled A.Gepreel Saleh Omran | 2012 | Chinese Physics B2012，21，11： | 20 |
| 4 | 基于模型的复杂地表区静校正方法显示文摘在简要介绍静校正处理中常用方法及其特点基础上,结合研究区的特点,本文提出了基于模型的静校正处理方法。根据该区近地表特点重新定义了沙丘底面(模型顶面),并与沙丘压实曲线结合建立了相对准确的近地表模型;针对区内微测井数据分布不均、折射层不稳定等问题,引入相对折射静校正方法,实现了对模型在复杂近地表变化区域的精度修正,保证了基准面校正的可靠性,并为后续地表一致性剩余静校正打下了良好基础。实际资料处理应用表明,此模型静校正方法可较好地适应复杂地表地区的静校正处理,提高低幅度构造的成像精度。 | 李卫忠 Saleh A. Al-Maghlouth Adnan Hasheme 唐文榜 王达远 | 2010 | 石油地球物理勘探2010，45，6： | 19 |
| 5 | Anterior knee pain following primary total knee arthroplasty显示文摘Despite improvements in technique and technology for total knee arthroplasty(TKA),anterior knee pain impacts patient outcomes and satisfaction.Addressing the prosthetic and surgical technique related causes of pain after TKA,specifically as it relates to anterior knee pain,can aid surgeons in addressing these issues with their patients.Design features of the femoral and patellar components which have been reported as pain generators include: Improper femoral as well as patellar component sizing or designs that result in patellofemoral stuffing; a shortened trochlear groove distance from the flange to the intercondylar box; and then surgical technique related issues resulting in: Lateral patellar facet syndrome; overstuffed patella/flange combination; asymmetric patellar resurfacing,improper transverse plane component rotation resulting in patellar subluxation/tilt.Any design consideration that allows impingement of extensor mechanism anatomical elements has the possibility of impacting outcome by becoming a pain generator.As the number of TKA procedures continues to increase,it is increasingly critical to develop improved,evidence based prostheses that maximize function and patient satisfaction while minimizing pain and other complications. | David Shervin Katelyn Pratt Travis Healey Samantha Nguyen William M Mihalko Mouhanad M El-Othmani Khaled J Saleh | 2015 | World Journal of Orthopedics2015，6，10： | 15 |
| 6 | Liuwei Dihuang, a traditional Chinese herbal formula, suppresses chronic inflammation and oxidative stress in obese rats显示文摘OBJECTIVE: To investigate the anti-infl ammatory, anti-oxidative stress, and adipokine-ameliorating effects of Liuwei Dihuang(LWDH), a traditional Chinese herbal formula, in obese rats. METHODS: After 2 weeks of acclimation with free access to regular rodent chow and water, obese-prone-caesarean-derived(OP-CD) rats were fed a modified AIN-93 G diet containing 60% energy from fat. Treatment was performed twice daily by gavage feeding with 500, 1 500, or 3 500 mg/kg body weight LWDH suspended in water(n=12 rats per group). Twelve obese-resistant-CD(OR-CD) rats were fed the atherogenic diet and gavaged with water, and served as the normal control. Blood biomarkers of inflammation, oxidative stress and adiponectin were measured post-sacrifi ce and used to determine the treatment effect of LWDH and assess the suitability of OR/OP-CD rats for studying these parameters. RESULTS: After 9 weeks of treatment, LWDH lowered serum C-reactive protein(CRP) and tumour necrosis factor-α(TNF-α) levels. Serum interleukin-6(IL-6) levels showed a tendency towards reduction, but were not signifi cantly different from the OP-CD control. Liver superoxide dismutase(SOD) activity was increased in response to all three doses of LWDH, while the levels of reduced(GSH) and oxidized glutathione(GSSG) and thiobarbituric acid reactive substances(TBARS) were unchanged. Serum adiponectin levels were increased in response to oral administration of LWDH at the dose of either 500 or 1 500 mg/kg body weight. In addition, comparisons between OR-CD and OP-CD rats revealed differential, and for some biomarkers, conflicting characteristics of high-fat diet-fed OP-CD rats in reference to obese human subjects in terms of infl ammatory and oxidative stress biomarkers and circulating adiponectin levels. CONCLUSION: The results show, for the fi rst time, the anti-infl ammatory, anti-oxidative stress and adiponectin-ameliorating effects of LWDH in obese rats. The suitability of the OR/OP-CD rat model as a research tool to study infl ammation, oxidative stress, and adipokine production requires further investigation. | Benjamin Perry Junzeng Zhang Tarek Saleh Yanwen Wang | 2014 | Journal of Integrative Medicine2014，12，5： | 14 |
| 7 | Highlights in pathogenesis of vitiligo显示文摘Vitiligo is a common pigmentary disorder. Many studies across decades and all over the world have attempted to illustrate the pathogenesis behind it; however, the pathogenesis of vitiligo remains elusive. This review article, we present the findings behind the most and updated theories behind this psychologically debilitating and disfiguring disease. The discussion begun with the role of genetic predisposition followed by neural theory first proposed in the 1950 s. Wehighlight the autoimmune hypothesis, followed by the reactive oxygen species model, zinc-α2-glycoprotein deficiency hypothesis, viral theory, intrinsic theory and biochemical, molecular and cellular alterations accounting for loss of functioning melanocytes in vitiligo. Many theories were elaborated to clarify vitiligo pathogenesis. It is a multifactorial disease involving the interplay of several factors. Future research is needed to clarify the interaction of these factors for better understanding of vitiligo pathogenesis and subsequent successful treatment. | Ghada F Mohammed Amal Hussein Gomaa Mohammed Saleh Al-Dhubaibi | 2015 | World Journal of Clinical Cases2015，3，3： | 13 |
| 8 | The Structure and Function of Major Plant Metabolite Modifications显示文摘Plants produce a myriad of structurally and functionally diverse metabolites that play many different roles in plant growth and development and in plant response to continually changing environmental conditions as well as abiotic and biotic stresses. This metabolic diversity is, to a large extent, due to chemical modification of the basic skeletons of metabolites. Here, we review the major known plant metabolite modifications and summarize the progress that has been achieved and the challenges we are facing in the field. We focus on discussing both technical and functional aspects in studying the influences that various modifications have on biosynthesis, degradation, transport, and storage of metabolites, as well as their bioactivity and toxicity. Finally, we discuss some emerging insights into the evolution of metabolic pathways and metabolite functionality. | Shouchuang Wang Saleh Alseekh Alisdair R.Fernie Jie Luo | 2019 | Molecular Plant2019，12，7： | 13 |
| 9 | Premature ejaculation:an update on definition and pathophysiology显示文摘Premature ejaculation(PE)is the most comm on male sexual dysfunction,which represents a diag no stic as well as a therapeutic challenge for physicians.However,no universally accepted definition is currently available for PE.As a result,physicians continue to diagnose patients with PE according to major guidelines set by the professional societies.These guidelines either recommend the use of validated questionnaires or patient-reported outcomes.Recent efforts directed toward classifying PE may help provide a better understanding of the prevalence and risk factors of this disorder.While the exact etiology of PE has not been clearly elucidated,several risk factors have been strongly reported in the literature.Clearly,to understand the revised definition of PE,its etiology and pathophysiology is necessary to improve the clinical management of this medical condition and form the basis of future research in this regard.In this review,we highlight the past and current definitions of PE and present an appraisal on the classifications and theories suggested for the etiopathogenesis of PE. | Mohammed Abu El-Hamd Ramadan Saleh Ahmad Majzoub | 2019 | Asian Journal of Andrology2019，21，5： | 12 |
| 10 | Reversibility of minimal hepatic encephalopathy following liver transplantation in Egyptian cirrhotic patients显示文摘AIM To evaluate the reversibility of minimal hepatic encephalopathy(MHE) following liver transplantation(LT) in Egyptian cirrhotic patients. METHODS This prospective study included twenty patients with biopsy-proven liver cirrhosis listed for LT and twenty ageand sex-matched healthy control subjects. All underwent neuro-psychiatric examination, laboratory investigations, radiological studies and psychometric tests including trail making test A(TMT A), TMT B, digit symbol test and serial dotting test. The psychometric hepatic encephalopathy score(PHES) was calculated for patients to diagnose MHE. Psychometric tests were repeated six months following LT in the cirrhotic patient group. RESULTS Before LT, psychometric tests showed highly significant deficits in cirrhotic patients in comparison to controls(P < 0.001). There was a statistically significant improvement in test values in the patient group after LT; however, their values were still significantly worse than those of the controls(P < 0.001). The PHES detected MHE in 16 patients(80%) before LT with a median value of -7 ± 3.5. The median PHES value was significantly improved following LT, reaching-4.5 ± 5(P < 0.001), and the number of patients with MHE decreased to 11(55%). The pre-transplant model for end-stage liver disease(MELD) score ≥ 15 was significantly related to the presence of post-transplant MHE(P = 0.005). More patients in whom reversal of MHE was observed had a pre-transplant MELD score < 15.CONCLUSION Reversal of MHE in cirrhotic patients could be achieved by LT, especially in those with a MELD score < 15. | Mahmoud A Osman Moataz M Sayed Khaled A Mansour Shereen A Saleh Wesam A Ibrahim Sara M Abdelhakam Mohamed Bahaa Wael A Yousry Hosam S Elbaz Reginia N Mikhail Azza M Hassan Ehab H Elsayed Dalia A Mahmoud | 2016 | World Journal of Hepatology2016，8，30： | 11 |
| 11 | Microstructure characterization and corrosion behavior of Mg-Y-Zn alloys with different long period stacking ordered structures显示文摘Mg-Y-Zn alloys with long period stacking ordered(LPSO)structure have received much attention recently and exhibit great potential in applications such as automotive,aerospace and in bio-medical fields.This paper aimed to investigate the effect of different phase constitution of LPSO structures on corrosion rate of bio-medical Mg-Y-Zn alloys.The results showed that as-cast Mg98.5Y1Zn0.5 alloys containing only 18R structure exhibited the highest corrosion resistance with the corrosion rate of 2.78 mm/year.The precipitation of 14H lamellas within a-Mg grains during solid solution treatment introduced the crystallographic orientation corrosion by accelerating micro-galvanic corrosion.The increase of 18R/14H interfaces deteriorated the corrosion resistance,and the grain boundaries also suffered from severe electrochemical dissolution.This work suggested that Mg-Y-Zn alloys with single LPSO structure(either 18R or 14H)exhibited better corrosion resistance than alloys with co-existence 18R and I4H LPSO structures. | Lisha Wang Jinghua Jiang Huan Liu Bassiouny Saleh Aibin Ma | 2020 | Journal of Magnesium and Alloys2020，8，4： | 11 |
| 12 | Clinical correlates of common corneal neovascular diseases: a literature review显示文摘A large subset of corneal pathologies involves the formation of new vessels(neovascularization), leading to compromised visual acuity. This article aims to review the clinical causes and presentations of corneal neovascularization(CNV) by examining the mechanisms behind common CNV-related corneal pathologies, with a particular focus on herpes simplex stromal keratitis,contact lenses-induced keratitis and CNV secondary to keratoplasty. Moreover, we reviewed CNV in the context of different types of corneal transplantation and keratoprosthesis, and summarized the most relevant treatment available so far. | Nizar Saleh Abdelfattah Mohamed Amgad Amira A Zayed Hamdy Salem Ahmed E Elkhanany Heba Hussein Nawal Abd El-Baky | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 10 |
| 13 | case of familial hyperlipoproteinemia type Ⅲ hypertriglyceridemia induced acute pancreatitis: role for outpatient apheresis maintenance therapy显示文摘Hypertriglyceridemic pancreatitis(HTGP) accounts for up to 10% of acute pancreatitis presentations in nonpregnant individuals and is the third most common cause of acute pancreatitis after alcohol and gallstones. There are a number of retrospective studies and case reports that have suggested a role for apheresis and insulin infusion in the acute inpatient setting. We report a case of HTGP in a male with hyperlipoproteinemia type Ⅲ who was treated successfully with insulin and apheresis on the initial inpatient presentation followed by bi-monthly outpatient maintenance apheresis sessions for the prevention of recurrent HTGP. We also reviewed the literature for the different inpatient and outpatient management modalities of HTGP. Given that there are no guidelines or randomized clinical trials that evaluate the outpatient management of HTGP, this case report may provide insight into a possible role for outpatient apheresis maintenance therapy. | Mohannad Abou Saleh Emad Mansoor Gregory S Cooper | 2017 | World Journal of Gastroenterology2017，23，40： | 10 |
| 14 | MicroTom Metabolic Network: Rewiring Tomato Metabolic Regulatory Network throughout the Growth Cycle显示文摘Tomato(Solanum lycopersicum)is a major horticultural crop worldwide and has emerged as a preeminent model for metabolic research.Although many research efforts have focused on the analysis of metabolite differences between varieties and species,the dynamics of metabolic changes during the tomato growth cycle and the regulatory networks that underlie these changes are poorly understood.In this study,we integrated high-resolution spatio-temporal metabolome and transcriptome data to systematically explore the metabolic landscape across 20 major tomato tissues and growth stages.In the resulting MicroTom Metabolic Network,the 540 detected metabolites and their co-expressed genes could be divided into 10 distinct clusters based on their biological functions.Using this dataset,we constructed a global map of the major metabolic changes that occur throughout the tomato growth cycle and dissected the underlying regulatory network.In addition to verifying previously well-established regulatory networks for important metabolites,we identified novel transcription factors that regulate the biosynthesis of important secondary metabolites such as steroidal glycoalkaloids and flavonoids.Our findings provide insights into spatiotemporal changes in tomato metabolism and generate a valuable resource for the study of metabolic regulatory processes in model plants. | Yan Li Yang Chen Lu Zhou Shengjie You Heng Deng Ya Chen Saleh Alseekh Yong Yuan Rao Fu Zixin Zhang Dan Su Alisdair R.Fernie Mondher Bouzayen Tao Ma Mingchun Liu Yang Zhang | 2020 | Molecular Plant2020，13，8： | 10 |
| 15 | Effects of rainfall patterns on runoff and rainfall-induced erosion显示文摘Rainfall-induced erosion involves the detachment of soil particles by raindrop impact and their transport by the combined action of the shallow surface runoff and raindrop impact.Although temporal variation in rainfall intensity(pattern)during natural rainstorms is a common phenomenon,the available information is inadequate to understand its effects on runoff and rainfall-induced erosion processes.To address this issue,four simulated rainfall patterns(constant,increasing,decreasing,and increasing-decreasing)with the same total kinetic energy were designed.Two soil types(sandy and sandy loam)were subjected to simulated rainfall using 15 cm×30 cm long detachment trays under infiltration conditions.For each simulation,runoff and sediment concentration were sampled at regular intervals.No obvious difference was observed in runoff across the two soil types,but there were significant differences in soil losses among the different rainfall patterns and stages.For varying-intensity rainfall patterns,the dominant sediment transport mechanism was not only influenced by raindrop detachment but also was affected by raindrop-induced shallow flow transport.Moreover,the efficiency of equations that predict the interrill erosion rate increased when the integrated raindrop impact and surface runoff rate were applied.Although the processes of interrill erosion are complex,the findings in this study may provide useful insight for developing models that predict the effects of rainfall pattern on runoff and erosion. | Morteza Alavinia Farzin Nasiri Saleh Hossain Asadi | 2019 | International Journal of Sediment Research2019，34，3： | 9 |
| 16 | Total knee arthroplasty for treatment of post-traumatic arthritis: Systematic review显示文摘AIM To review and report functional outcomes, complications,and survivorship associated with total knee arthroplasty(TKA) in the treatment of post-traumatic arthritis(PTA).METHODS We conducted a systematic review according to the PRISMA guidelines. We searched PubMed, Cochrane Library, and SCOPUS in December 2015 for Englishlanguage clinical research studies, both prospective and retrospective, examining the use of TKA for the treatment of PTA. All relevant articles were accessed in full. The manual search included references of retrieved articles.We extracted data on patients' demographics and clinical outcomes, including preoperative diagnosis and pre- and post-operative functional scores. We summarized the data and reported the results in tables and text.RESULTS Sixteen studies, four prospective and ten retrospective,examined patients who underwent TKA for PTA due to fractures of the proximal tibia, patella, and/or distal femur. Eleven studies utilized the Knee Society Scores criteria to assess functional outcomes. All studies utilizing these criteria reported an improvement in functional and knee scores of patients following TKA. Further, studies reported an increased range of motion(ROM) and reduction of pain following surgery. The most commonly reported complications with TKA included infection, stiffness, wound complications, intraoperative rupture of tendons, and osteolysis/polyethylene wear. The overwhelming majority of these complications occurred within the first two years following surgery. Six studies examined the survivorship of TKA with subsequent revision for any reason as an endpoint. Compared to patients with osteoarthritis, patients with PTA required more revisions, the majority for polyethylene wear.CONCLUSION Although associated with higher complication rates,TKA is an effective treatment for PTA, as it improves ROM, pain and functional outcomes. | Hesham Saleh Stephen Yu Jonathan Vigdorchik Ran Schwarzkopf | 2016 | World Journal of Orthopedics2016，7，9： | 9 |
| 17 | Mycobacterium avium subspecies paratuberculosis causes Crohn's disease in some inflammatory bowel disease patients显示文摘Crohn’s disease(CD)is a chronic inflammatory condition that plagues millions all over the world.This debilitating bowel disease can start in early childhood and continue into late adulthood.Signs and symptoms are usually many and multiple tests are often required for the diagnosis and confirmation of this disease.However,little is still understood about the cause(s)of CD.As a result,several theories have been proposed over the years.One theory in particular is that Mycobacterium avium subspecies paratuberculosis(MAP)is intimately linked to the etiology of CD.This fastidious bacterium also known to cause Johne’s disease in cattle has infected the intestines of animals for years.It is believed that due to the thick,waxy cell wall of MAP it is able to survive the process of pasteurization as well as chemical processes seen in irrigation purification systems.Subsequently meat,dairy products and water serve as key vehicles in the transmission of MAP infection to humans(from farm to fork)who have a genetic predisposition,thus leading to the development of CD.The challenges faced in culturing this bacterium from CD are many.Examples include its extreme slow growth,lack of cell wall,low abundance,and its mycobactin dependency.In this review article,data from 60 studies showing the detection and isolation of MAP by PCR and culture techniques have been reviewed.Although this review may not be 100%comprehensive of all studies,clearly the majority of the studies overwhelmingly and definitively support the role of MAP in at least30%-50%of CD patients.It is very possible that lack of detection of MAP from some CD patients may be due to the absence of MAP role in these patients.The latter statement is conditional on utilization of methodology appropriate for detection of human MAP strains.Ultimately,stratification of CD and inflammatory bowel disease patients for the presence or absence of MAP is necessary for appropriate and effective treatment which may lead to a cure. | Saleh A Naser Sudesh R Sagramsingh Abed S Naser Saisathya Thanigachalam | 2014 | World Journal of Gastroenterology2014，20，23： | 9 |
| 18 | Hepatic Hemangioendothelioma: An update显示文摘Primary epithelioid hemangioendotheliomas of the liver(EHL)are rare tumors with a low incidence.The molecular background of EHL is still under investigation,with WWTR1-CAMPTA1 mutation may function as a tumor marker.Commonly,this tumor is misdiagnosed with angiosarcoma,cholangiocarcinomas,metastatic carcinoma,and hepatocellular carcinoma(sclerosing variant).Characteristic features on imaging modalities such as ultrasound,computed tomography,magnetic resonance imaging and positron emission tomography/computed tomography guide in diagnosis and staging.The“halo sign”and the“lollipop sign”on computed tomography and magnetic resonance imaging are described in the literature.Currently,there are no standardized guidelines for treating EHL with treatment options are broad including:chemotherapy,ablation,surgery and liver transplantation with inconsistent results. | Mayur Virarkar Mohammed Saleh Radwan Diab Melissa Taggart Peeyush Bhargava Priya Bhosale | 2020 | World Journal of Gastrointestinal Oncology2020，12，3： | 8 |
| 19 | Development of a new connection for precast concrete walls subjected to cyclic loading显示文摘The Industrialized Building System(IBS) was recently introduced to minimize the time and cost of project construction.Accordingly, ensuring the integration of the connection of precast components in IBS structures is an important factor that ensures stability of buildings subjected to dynamic loads from earthquakes, vehicles, and machineries.However, structural engineers still lack knowledge on the proper connection and detailed joints of IBS structure construction.Therefore, this study proposes a special precast concrete wall-to-wall connection system for dynamic loads that resists multidirectional imposed loads and reduces vibration effects(PI2014701723).This system is designed to connect two adjacent precast wall panels by using two steel U-shaped channels(i.e., male and female joints).During casting, each joint is adapted for incorporation into a respective wall panel after considering the following conditions: one side of the steel channel opens into the thickness face of the panel; a U-shaped rubber is implemented between the two channels to dissipate the vibration effect; and bolts and nuts are used to create an extension between the two U-shaped male and female steel channels.The developed finite element model of the precast wall is subjected to cyclic loads to evaluate the performance of the proposed connection during an imposed dynamic load.Connection performance is then compared with conventional connections based on the energy dissipation, stress, deformation, and concrete damage in the plastic range.The proposed precast connection is capable of exceeding the energy absorption of precast walls subjected to dynamic load, thereby improving its resistance behavior in all principal directions. | Ramin Vaghei Farzad Hejazi Hafez Taheri Mohd Saleh Jaafar Farah Nora Aznieta Abdul Aziz | 2017 | Earthquake Engineering and Engineering Vibration2017，16，1： | 8 |
| 20 | Role of essential oils in food safety: Antimicrobial and antioxidant applications显示文摘Essential oils(EOs)are more complex and comprise a number of volatile and natural bioactive compounds,which often used in food industries as the best alternatives.This review focuses on the impact of EOs and the roles of their major components in food manufacturing as natural preservatives with the related mechanisms of action.In addition,the major bioactive molecules of different types of EOs and their pharmacological activities such as antioxidant,antifungal and antimicrobial effects on crop protection were also discussed.The major compounds of EOs represent potential antioxidant,antimicrobial and antifungal activities through various mechanisms.Different types of EOs such as tea tree oil,lemon oil,clove oil,cinnamon oil and thyme oil from various traditional plants,have significantly showed better antimicrobial and antioxidant activities,and also effectively increased the shelf lives of the cereal products and increased the quality of food safety.The major groups of EOs such as terpenes and aromatic volatile compounds,play a key role in food safety without affecting the quality.Due to their various activities including antioxidant and antimicrobial activities,EOs could be used as alternative preservatives to increase the shelf lives of cereals and crops. | Sundaresan Bhavaniramya Selvaraju Vishnupriya Mohammad Saleh Al-Aboody Rajendran Vijayakumar Dharmar Baskaran | 2019 | Grain & Oil Science and Technology2019，2，2： | 8 |
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