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| 1 | IL28B polymorphism and cytomegalovirus predict response to treatment in Egyptian HCV type 4 patients显示文摘AIM:To test whether the status of positive cytomegalovirus(CMV) DNA detection adds to the predictive value of IL28B and to further categorize C/T allele carriers.METHODS:This study included 166 chronic hepatitis C(CHC) patients who received combined interferon and ribavirin therapy for 48 wk,84 spontaneous hepatitis C virus(HCV) resolvers who were positive for IgG anti-HCV antibody and negative for HCV RNA,and 100 healthy subjects who were negative for both HCV antibodies and RNA as controls.Genomic DNA from peripheral blood was used for IL28B rs.12979860 single nucleotide polymorphism(SNP) and CMV DNA detection.A 139 bp fragment containing IL28B SNP was amplified in all subjects by polymerase chain reaction using a specifically designed primer.Then the IL28B rs.12979860 SNP was detected by restriction fragment length polymorphism(RFLP) genotyping.The presence of CMV DNA was tested by amplification of the gB1 gene using nested polymerase chain reaction.The role of CMV and IL28B rs.12979860 SNP genotypes in determining the response rate to combined interferon therapy and clinical status of patients were statistically analyzed.RESULTS:Current data showed that 67% of patients carrying the IL28B 12979860 C/C allele had a sustained viral response(SVR) while the genotypes C/T and TT were associated with lower SVR rates,50% and 48%,respectively.SVR rates for the C/C allele were lower than other HCV genotypes and/or other populations.Genotype CC was associated with the response to interferon(P = 0.025).Genotype C/C was reduced from 48% in controls to 14% in CHC patients suggesting its protective role against progression to chronicity.The majority of spontaneously cleared subjects(86%) were C/C,confirming its protective role.The C/T allele was present in 71% of CHC patients compared with 38% of controls,so the use of IL28B SNP genotyping only in these patients may be of little value as a predictor of response.CMV reactivation occurred in 40% of CHC patients.Co-infection with CMV seriously diminished the response to interferon(IFN) therapy,with SVR rates in C/C genotypes 87.5% in CMV-negative patients and 12.5% in CMV-positive patients(P < 0.0001).SVR rates among C/T carriers were reduced to < 50% in patients with positive CMV DNA while the non-response rate doubled.These data indicate that a supplemental assay for CMV viremia adds to the prognostic value of IL28B genotyping.CONCLUSION:The results suggest that both genetic(i.e.,spontaneous) and therapeutic(IFN-based therapy) arms are complementary in the battle against HCV.CMV DNA testing may be of value to better predict the response to IFN,particularly in IL28B C/T carriers. | Mostafa K El Awady Noha G Bader El Din Ashraf Tabll Yaser El Hosary Ashraf O Abdel Aziz Hesham El Khayat Mohsen Salama Tawfeek H Abdelhafez | 2013 | World Journal of Gastroenterology2013，19，2： | 8 |
| 2 | Malignant peripheral primitive neuroectodermal tumor-peripheral neuroepithelioma of the head and neck : a clinicopathologic study of five cases and review of the literature 显示文摘 | Nikitakis NG Salama AR O'Malley BW | 2003 | Head Neck2003，25，6： | 1 |
| 3 | Effects of expo- sure to a mobile phone on testicular function and structure in adult rabbit显示文摘 | Salama N Kishimoto T Kanayama H O | 2008 | Int J Andro2008，33，1： | 1 |
| 4 | Malignant peripheral primitive neuroectodermal tumor-peripheral neuroepithelioma of the head and neck:a clinicopathologic study of five cases and review of the literature显示文摘 | Nikitakis N G Salama A R O'Malley B W | 2003 | Head Neck2003，25，6： | 1 |
| 5 | Relationship between fetuin-A and systemic lupus erythematosus as a predictor marker for atherosclerosis显示文摘 | Mosa O F Mohamad I H Salama M M | 2012 | Am Med J2012，3，： | 1 |
| 6 | Maligant peripheral primitive neuroectodermal tumor-peripheral neuroepithelioma of the head and neck: a clinicopathologic study of five cases and review of the literature显示文摘 | Nikitakis NG Salama AR O'Malley BW Jr | 2003 | Head Neck2003，25，6： | 1 |
| 7 | Immuno-modulatory effects of myrrh(commiphory molmol)in com-parison with turmeric(curcuma longa)in mice显示文摘 | EI-Ashmawy Z M Ashry K M Salama O M | 2006 | Alexan-dria Journal of Pharm aceutical Science2006，20，1： | 1 |
| 8 | A Sequential Injection Method for the Determination of Aluminum in Drinking Water Using Fluorescence Enhancement of the Aluminum - morin Complex in Micellar Media显示文摘 | KINDY S M Z SULIMAN F O SALAMA S B | 2003 | Microchemical Journal2003，74，： | 1 |
| 9 | L and E selectins in acute myeloid leukemia:expression,clinical relevance and relation to patient outcome显示文摘 | AREF S SALAMA O AL-TONBARY Y | 2002 | Hematology2002，7，2： | 1 |
| 10 | Assessment of bcl-2 expression as modulator of fas mediated apoptosis in acute leukemia显示文摘 | Aref S Salama O AL-Tonbary Y | 2004 | Hematology2004，9，2： | 1 |
| 11 | Flavonoids from violet flowers of Syringa vulgaris 显示文摘 | Ahmad M Salama O | 1987 | Pak J Sci Ind Res (Pakistan)1987，30，2： | 1 |
| 12 | Velocity distribution inside and above branched flexible roughness 显示文摘 | EI-HAKIM O SALAMA M M | 1992 | Journal of the Irrigation and Drainage Engineering1992，118，6： | 1 |
| 13 | Ififormation tracking approach to segmentation of ultrasound imagery of the prostate 显示文摘 | Xu RS Michailovich O salama M | 2010 | IEEE Trans Ultrason Ferroelectr Freq Control2010，57，8： | 1 |
| 14 | Velocity distribution inside and above branched flexible roughness显示文摘 | Ei-Hakim O Salama M M | 1992 | Journal of the Irrigation and Drainage Engineering1992，118，6： | 1 |
| 15 | Offshore composites: transition barriers to an enabling technology显示文摘 | OCHOA O O SALAMA M M | 2005 | Composites Science and Technology2005，65，1516： | 1 |
| 16 | Unbalanced bone turnover in children with beta-thalassemia显示文摘 | SALAMA O S AL TONGBARY Y A SHAHIN R A | 2006 | Hematology2006，11，3： | 1 |
| 17 | Influence of Intravenous Immunoglobulin Treatment on Thrombopoiesis显示文摘 | Meyer O Winter O Salama A | 2012 | Transfus Med Hemother2012，39，3： | 1 |
| 18 | 60 beta-D-xy- lopyranosylcatalpol, A New Iridoid Glycoside from Verbascum Thapsiforrrze显示文摘 | Swiatek L Salama O Sticher O | 1982 | Planta Med1982，45，： | 1 |
| 19 | Offshore composites: Transition barriers to an enabling technology显示文摘 | Ochoa O O Salama M M | 2005 | Composites Science and Technology Corrected Proof Available online2005，12，6： | 1 |
| 20 | Flavonoids from violet flowers of Syringa vularis显示文摘 | AHMAD M SALAMA O | 1987 | Park J Sci Ind Res1987，30，2： | 1 |
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