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| 1 | From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world显示文摘Hepatocellular carcinoma(HCC) is the most frequent primary liver malignancy and the third cause of cancer-related death in the Western Countries. The well-established causes of HCC are chronic liver infections such as hepatitis B virus or chronic hepatitis C virus, nonalcoholic fatty liver disease, consumption of aflatoxins and tobacco smocking. Clinical presentation varies widely; patients can be asymptomatic while symptomatology extends from right upper abdominal quadrant paint and weight loss to obstructive jaundice and lethargy. Imaging is the first key and one of the most important aspects at all stages of diagnosis, therapy and follow-up of patients with HCC. The Barcelona Clinic Liver Cancer Staging System remains the most widely classification system used for HCC management guidelines. Up until now, HCC remains a challenge to early diagnose, and treat effectively; treating management is focused on hepatic resection, orthotopic liver transplantation, ablative therapies, chemoembolization and systemic therapies with cytotocix drugs, and targeted agents. This review article describes the current evidence on epidemiology, symptomatology, diagnosis and treatment of hepatocellular carcinoma. | Dimitrios Dimitroulis Christos Damaskos Serena Valsami Spyridon Davakis Nikolaos Garmpis Eleftherios Spartalis Antonios Athanasiou Demetrios Moris Stratigoula Sakellariou Stylianos Kykalos Gerasimos Tsourouflis Anna Garmpi Ioanna Delladetsima Konstantinos Kontzoglou Gregory Kouraklis | 2017 | World Journal of Gastroenterology2017，23，29： | 44 |
| 2 | Management bone loss of the proximal femur in revision hip arthroplasty: Update on reconstructive options显示文摘The number of revision total hip arthroplasties is expected to rise as the indications for arthroplasty will expand due to the aging population. The prevalence of extensive proximal femoral bone loss is expected to increase subsequently. The etiology of bone loss from the proximal femur after total hip arthroplasty is multifactorial. Stress shielding, massive osteolysis, extensive loosening and history of multiple surgeries consist the most common etiologies. Reconstruction of extensive bone loss of the proximal femur during a revision hip arthroplasty is a major challenge for even the most experienced orthopaedic surgeon. The amount of femoral bone loss and the bone quality of the remaining metaphyseal and diaphyseal bone dictate the selection of appropriate reconstructive option. These include the use of impaction allografting, distal press-fit fixation, allograft-prosthesis composites and tumor megaprostheses. This review article is a concise review of the current literature and provides an algorithmic approachfor reconstruction of different types of proximal femoral bone defects. | Vasileios I Sakellariou George C Babis | 2014 | World Journal of Orthopedics2014，5，5： | 5 |
| 3 | Review of state-of-the-art decision support systems (DSSs) for prevention and suppression of forest fires显示文摘Forest ecosystems are our priceless natural resource and are a key component of the global carbon budget. Forest fires can be a hazard to the viability and sustainable management of forests with consequences for natural and cultural environments, economies, and the life quality of local and regional populations. Thus, the selection of strategies to manage forest fires, while considering both functional and economic efficiency, is of primary importance. The use of decision support systems(DSSs) by managers of forest fires has rapidly increased. This has strengthened capacity to prevent and suppress forest fires while protecting human lives and property. DSSs are a tool that can benefit incident management and decision making and policy, especially for emergencies such as natural disasters. In this study we reviewed state-of-the-art DSSs that use: database management systems and mathematical/economic algorithms for spatial optimization of firefighting forces; forest fire simulators and satellite technology for immediate detection and prediction of evolution of forest fires; GIS platforms that incorporate several tools to manipulate, process and analyze geographic data and develop strategic and operational plans. | Stavros Sakellariou Stergios Tampekis Fani Samara Athanassios Sfougaris Olga Christopoulou | 2017 | Journal of Forestry Research2017，28，6： | 3 |
| 4 | Hepatitis C in hemodialysis patients显示文摘Despite reduction of hepatitis C prevalence after recognition of the virus and testing of blood products, hemodialysis(HD) patients still comprise a high risk group. The natural history of hepatitis C virus(HCV) infection in dialysis is not fully understood while the clinical outcome differs from that of the general population. HD patients show a milder liver disease with lower aminotransferase and viral levels depicted bymilder histological features on liver biopsy. Furthermore, the 'silent' clinical course is consistent with a slower disease progression and a lower frequency of cirrhosis and hepatocellular carcinoma. Potential explanations for the 'beneficial' impact of uremia and hemodialysis on chronic HCV infection are impaired immunosurveillance leading to a less aggressive host response to the virus and intradialytic release of 'hepatoprotective' cytokines such as interferon(IFN)-α and hepatocyte growth factor. However, chronic hepatitis C is associated with a higher liver disease related cardiovascular and allcause mortality of HD patients. Therapy is indicated in selected patients groups including younger patients with low comorbidity burden and especially renal transplant candidates, preferably after performance of a liver biopsy. According to current recommendations, choice of treatment is IFN or pegylated interferon with a reported sustained viral response at 30%-40% and a withdrawal rate ranging from 17% to 30%. New data regarding combination therapy with low doses of ribavirin which provide higher standard variable rates and good safety results, offer another therapeutic option. The new protease inhibitors may be the future for HCV infected HD patients, though data are still lacking. | Smaragdi Marinaki John N Boletis Stratigoula Sakellariou Ioanna K Delladetsima | 2015 | World Journal of Hepatology2015，7，3： | 2 |
| 5 | Role of attP in integrase-mediated integration of the shigella resistance locus pathogenicity island of shigella flexneri显示文摘 | Turner SA Luck SN Sakellaris H | 2004 | Antimicrob Agents Chemother2004，48，3： | 1 |
| 6 | Heteronuclear decoupling in NMR of liquid crystals using continuous phase modulation显示文摘 | De Pa-pe G Sakellariou D Hodgkinson P | 2003 | Chem Phys Lett2003，368，56： | 1 |
| 7 | Posttraumatic meningitis:bacteriology,hydrocephalus and outcome显示文摘 | Baltas I Tsoulfa S Sakellariou P | 1994 | Neurosurgery1994，35，3： | 1 |
| 8 | Homonuclear dipolar decoupling in solid-state NMR using continuous phase modulation显示文摘 | Sakellariou D Lesage A Hodgkinson P | 2000 | Chem Phys Lett2000，319，： | 1 |
| 9 | Role of attP in integrase-mediated intergration of the Shigella resistance locus pathogenicty island of Shigella flexneri 显示文摘 | Turner SA Luck SN Sakellaris H | 2004 | Antimicrob Agents Chemother2004，48，： | 1 |
| 10 | A study of slope stability prediction using neural networks 显示文摘 | SAKELLARIOU MG FERENTINOU MD | 2005 | Geotechnical and Geological Engineering2005，23，4： | 1 |
| 11 | Concentration of 3tetracyclines in plasma,gingival crevice fluid and saliva显示文摘 | Sakellari D Goodson JM Kolokotronis A | 2006 | J Clin Periodontal2006，27，1： | 1 |
| 12 | Irreversible Capital and the Stock Market Response to Shocks in Profitability 显示文摘 | Sakellaris P | 1997 | International Economic Review1997，38，2： | 1 |
| 13 | Effects of ropivacaine infiltration on cortisol and prolactin responses to postoperative pain after inguinal hernioraphy in children显示文摘 | Sakellaris G Petrakis I Makatounaki K | 2004 | J Pediatr Surg2004，39，9： | 1 |
| 14 | Three-di mensional metallic photonic crystals with optical bandgaps 显示文摘 | Vasilantonakis N Terzaki K Sakellari I | 2012 | Adv Mater2012，24，8： | 1 |
| 15 | Contrast STRAFI-MASimaging 显示文摘 | WONG A SAKELLARIOU D | 2010 | Journal of Magnetic Resonance2010，206，2： | 1 |
| 16 | A study of slope stability prediction using neural networks显示文摘 | Sakellariou M G Ferentinou M D | 2005 | Geotechnical & Geological Engineering2005，23，4： | 1 |
| 17 | Effects of ropivacaine infiltration on cortisol and prolactin responses to postoperative pain after inguinal hernioraphy in children 显示文摘 | Sakellaris G Petrakis I Makatounaki K | 2004 | J Pediatr Surg2004，39，9： | 1 |
| 18 | Alternate site pacing in patients at risk for heart failure显示文摘 | Manolis AS Sakellariou D Andrikopoulos GK | 2008 | Angiology2008，59，2： | 1 |
| 19 | Concentration of 3tetracyclines in plasma,gingival crevice fluid and saliva显示文摘 | Sakellari D Goodsord M Kolokotronis A | 2000 | J ClinPeriodontol2000，27，1： | 1 |
| 20 | Determination of 13 synthetic food colorants in water-soluble foods by reversed-phase high-performance liquid chromatography coupled with diode-array detector 显示文摘 | Minioti K S Sakellariou C F Thomaidis N S | 2007 | Analytica ChimicaActa2007，583，1： | 1 |
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