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| 1 | Retrospective cohort study Lower incidence of complications in endoscopic nasobiliary drainage for hilar cholangiocarcinoma显示文摘AIM:To identify the most effective endoscopic biliary drainage technique for patients with hilar cholangiocarcinoma.METHODS:In total,118 patients with hilar cholangiocarcinoma underwent endoscopic management[endoscopic nasobiliary drainage(ENBD)or endoscopic biliary stenting]as a temporary drainage in our institution between 2009 and 2014.We retrospectively evaluated all complications from initial endoscopic drainage to surgery or palliative treatment.The risk factors for biliary reintervention,post-endoscopic retrograde cholangiopancreatography(post-ERCP)pancreatitis,and percutaneous transhepatic biliary drainage(PTBD)were also analyzed using patient-and procedure-related characteristics.The risk factors for bilateral drainage were examined in a subgroup analysis of patients who underwent initial unilateral drainage.RESULTS:In total,137 complications were observed in92(78%)patients.Biliary reintervention was required in 83(70%)patients.ENBD was significantly associated with a low risk of biliary reintervention[odds ratio(OR)=0.26,95%CI:0.08-0.76,P=0.012].Post-ERCP pancreatitis was observed in 19(16%)patients.An absence of endoscopic sphincterotomy was significantly associated with post-ERCP pancreatitis(OR=3.46,95%CI:1.19-10.87,P=0.023).PTBD was required in 16(14%)patients,and Bismuth type III or IV cholangiocarcinoma was a significant risk factor(OR=7.88,95%CI:1.33-155.0,P=0.010).Of 102 patients with initial unilateral drainage,49(48%)required bilateral drainage.Endoscopic sphincterotomy(OR=3.24,95%CI:1.27-8.78,P=0.004)and Bismuth II,III,or IV cholangiocarcinoma(OR=34.69,95%CI:4.88-736.7,P<0.001)were significant risk factors for bilateral drainage.CONCLUSION:The endoscopic management of hilar cholangiocarcinoma is challenging.ENBD should be selected as a temporary drainage method because of its low risk of complications. | Kazumichi Kawakubo Hiroshi Kawakami Masaki Kuwatani Shin Haba Taiki Kudo Yoko A Taya Shuhei Kawahata Yoshimasa Kubota Kimitoshi Kubo Kazunori Eto Nobuyuki Ehira Hiroaki Yamato Manabu Onodera Naoya Sakamoto | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，9： | 26 |
| 2 | Optimizing processing varibles in high-temperature brazing with nickel-based filler metals 显示文摘 | Sakamoto A Fujiwara C Hattori T | 1989 | Welding Journal1989，，3： | 2 |
| 3 | Enhanced tolerance to light stress of transgenic Arabidopsis plants that express the codA gene for a bacterial choline oxidase显示文摘 | SAKAMOTO A | 1999 | Plant Molecular Biology1999，40，： | 1 |
| 4 | The effects of propofol on neutrophil function,lipid peroxidation and inflammatory response during elective coronary artery bypass grafting in patients with impaired ventricular function显示文摘 | Corcoran TB Engel A Sakamoto H | 2006 | Br J Anaesth2006，97，6： | 1 |
| 5 | Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma显示文摘 | Tsuchiya A Sakamoto M Yasuda J | 2003 | Am J Pathol2003，163，6： | 1 |
| 6 | Bcl6 Acts as an amplifier for the generation and proliferative capacity of central memory CD8^+ T cells显示文摘 | Ichii H Sakamoto A Kuroda Y | 2004 | J Immunol2004，173，2： | 1 |
| 7 | H-ras oncogene mutation in dedifferentiated chondrosarcoma: polymerase chain reaction-restriction fragmem length polymorphism analysis显示文摘 | Sakamoto A Oda Y Adachi T | 2001 | Mod Pathol2001，14，4： | 1 |
| 8 | Overexpres- sion of os- teopontin in hepatocellular carcinoma 显示文摘 | Gotoh M Sakamoto M Kanetak A K | 2005 | Pathol lnt2005，52，1： | 1 |
| 9 | MicroRNA profiles in cisplatin-induced apoptosis of hepatoceliular carcinoma cel|s 显示文摘 | Miyata M Morishita A Sakamoto T | 2015 | lnt J Oncol2015，47，2： | 1 |
| 10 | A clinicopathologie entity for a highrisk group of papillary and follicular carcinomas 显示文摘 | Sakamoto A Kasai N Sugano H Poorly differentiated carcinoma of the thyroid | 1983 | Cancer1983，52，10： | 1 |
| 11 | Selection of food sources by Ru-ditapes philippinarum and Mactra veneriformis (Bivalva : Mol-lusca) determined from stable isotope analysis 显示文摘 | Kasai A Horie H Sakamoto W | 2004 | Fisheries Sci2004，70，： | 1 |
| 12 | Control of Homeostasisof CD8 + Memory T Cells by Opposing Cytokines显示文摘 | Ku CC Murakami M Sakamoto A | 2000 | Science2000，288，： | 1 |
| 13 | Persistent activation of Nrf2through p62 in hepatocellular carcinoma cells显示文摘 | Inami Y Waguri S Sakamoto A | 2011 | J Cell Biol2011，193，2： | 1 |
| 14 | Pathogenesis of Chiari malformation:morphometric study of the posterior cranial fossa显示文摘 | Sakamoto H Hakuba A | 1997 | J N eurosurg1997，86，1： | 1 |
| 15 | Effects of ulinastatin treatment on the cardiopulmonary bypass-in-duced hemodynamic instability and pulmonary dysfunction显示文摘 | Nakanishi K Takeda S Sakamoto A | 2006 | Critical Care Medicine2006，34，5： | 1 |
| 16 | Effects of dietary lipids, fatty acids, and phospholipids on growth and survival of prawn (Penaeusjaponicus) larvae 显示文摘 | Kanazawa A Teshima S Sakamoto M | 1985 | Aquaculture1985，50，12： | 1 |
| 17 | MMP14 gene polymorphisms in chronic obstructive pulmonary disease显示文摘 | Saitoh W Sakamoto T Hegab A E Nomura A Ishii Y Morishima Y Kai S Iizuka T Kiwamoto T Matsuno Y Massoud H H Massoud H M Hassanein K M Sekizawa K | 2006 | Int J Mol Med2006，17，6： | 1 |
| 18 | The clinical role of MDR1 gene expression in human lung cancer显示文摘 | Oka M Fukuda M Sakamoto A | 1997 | Anticancer Res1997，17，1： | 1 |
| 19 | Weekly carboplatin and paclitaxel is safe,active,and well tolerated in recurrent ovarian cancer cases of Japanese women previously treated with cisplatin-containing multidrug chemotherapy显示文摘 | Kikuchi A Sakamoto H Yamamoto T | 2005 | Int J Gynecol Cancer2005，15，1： | 1 |
| 20 | Chondromyxoid fibroma of the clavicle显示文摘 | Sakamoto A Tanaka K Matsuda S | 2006 | Orthop Sci2006，11，5： | 1 |
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