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| 1 | Occult hepatitis B virus and hepatocellular carcinoma显示文摘Occult hepatitis B virus(HBV)infection(OBI)is a challenging pathobiological and clinical issue that has been widely debated for several decades.By definition,OBI is characterized by the persistence of HBV DNA in the liver tissue(and in some cases also in the serum)in the absence of circulating HBV surface antigen(HBsAg).Many epidemiological and molecular studies have indicated that OBI is an important risk factor for hepatocellular carcinoma(HCC)development.OBI may exert direct pro-oncogenic effects through the activation of the same oncogenic mechanisms that are activated in the course of an HBsAg-positive infection.Indeed,in OBI as in HBV-positive infection,HBV DNA can persist in the hepatocytes both integrated into the host genome as well as free episome,and may maintain the capacity to produce proteins-mainly X protein and truncated preS-S protein-provided with potential transforming properties.Furthermore,OBI may indirectly favor HCC development.It has been shown that the persistence of very low viral replicative activity during OBI may induce mild liver necro-inflammation continuing for life,and substantial clinical evidence indicates that OBI canaccelerate the progression of liver disease towards cirrhosis that is considered the most important risk factor for HCC development. | Teresa Pollicino Carlo Saitta | 2014 | World Journal of Gastroenterology2014，20，20： | 13 |
| 2 | Distribution of bleeding gastrointestinal angioectasias in a Western population显示文摘AIM:To define which segments of the gastrointestinal tract are most likely to yield angioectasias for ablative therapy. METHODS:A retrospective chart review was performed for patients treated in the Louisiana State University Health Sciences Center Gastroenterology clinics between the dates of July 1, 2007 and October 1, 2010. The selection of cases for review was initiated by use of our electronic medical record to identify all patients with a diagnosis of angioectasia, angiodysplasia, or arteriovenous malformation. Of these cases, chart reviews identified patients who had a complete evaluation of their gastrointestinal tract as defined by at least one upper endoscopy, colonoscopy and small bowel capsule endoscopy within the past three years. Patients without evidence of overt gastrointestinal bleeding or iron deficiency anemia associated with intestinal angioectasias were classified as asymptomatic and excluded from this analysis. Thirty-five patients with confirmed, bleeding intestinal angioectasias who had undergone complete endoscopic evaluation of the gastrointestinal tract were included in the final analysis. RESULTS:A total of 127 cases were reviewed. Sixtysix were excluded during subsequent screening due to lack of complete small bowel evaluation and/or lack of documentation of overt bleeding or iron deficiency anemia. The 61 remaining cases were carefully examined with independent review of endoscopic images as well as complete capsule endoscopy videos. This anal- ysis excluded 26 additional cases due to insufficient records/images for review, incomplete capsule examination, poor capsule visualization or lack of confirmation of typical angioectasias by the principal investigator on independent review. Thirty-five cases met criteria for final analysis. All study patients were age 50 years or older and 13 patients (37.1%) had chronic kidney disease stage 3 or higher. Twenty of 35 patients were taking aspirin (81 mg or 325 mg), clopidogrel, and/or warfarin, with 8/20 on combination therapy. The number and location of angioectasis was documented for each case. Lesions were then classified into the following segments of the gastrointestinal tract:esophagus, stomach, duodenum, jejunum, ileum, right colon and left colon. The location of lesions within the small bowel observed by capsule endoscopy was generally defined by percentage of total small bowel transit time with times of 0%-9%, 10%-39%, and 40%-100% corresponding to the duodenum, jejunum and ileum, respectively. Independent review of complete capsule studies allowed for deviation from this guideline if capsule passage was delayed in one or more segments. In addition, the location and number of angioectasias observed in the small bowel was further modified or confirmed by subsequent device-assisted enteroscopy (DAE) performed in the 83% of cases. In our study population, angioectasias were most commonly found in the jejunum (80%) followed by the duodenum (51%), stomach (22.8%), and right colon (11.4%). Only two patients were found to have angioectasias in the ileum (5.7%). Twenty-one patients (60%) had angioectasias in more than one location.CONCLUSION:Patients being considered for endoscopic ablation of symptomatic angioectasias should undergo push enteroscopy or anterograde DAE and reinspection of the right colon. | Elizabeth Bollinger Daniel Raines Patrick Saitta | 2012 | World Journal of Gastroenterology2012，18，43： | 5 |
| 3 | Cardiovascular effects of raloxifene hydrchloride显示文摘 | Morabito N Frisina N | 2001 | Cardiovasc Drug Rev2001，19，1： | 1 |
| 4 | Anti-obesity and cardiovascular toxic effects of Citrus aurantium extracts in the rat: A preliminary report显示文摘 | Calapai G Firenzuoli F Saitta A et ol | 1999 | Fitoterapia1999，70，6： | 1 |
| 5 | Risk factors for postoperative delirium after colorectal surgery for carcinoma显示文摘 | Patti R Saitta M Cusumano G | 2011 | Eur J Oncol Nurs2011，15，5： | 1 |
| 6 | Tumor necrosis factor in myocardial ischemia and reperfusion 显示文摘 | Squadrito F Saitta A Altavilla D | 1993 | Cardiologia1993，38，1： | 1 |
| 7 | Randomized, double-blind, placebo-contrelled study on effects of raloxifene and hormone replacement therapy on plasma no concentrations, endothelin-1 levels,and endothelium-dependent vasodilation in postmenopansal women 显示文摘 | Saitta A Ahavilla D Cucinotta D | 2001 | Arterioacler Thromb Vasc Biol2001，21，9： | 1 |
| 8 | High performance liquid chromatography coupled with atmospheric pressure chemical ionization mass spectrometry for sensitive determination of bioactive amines in donkey milk显示文摘 | TORRE G L SAITTA M POTORT A G | 2010 | Journal of Chromatography A2010，1217，： | 1 |
| 9 | A continuous vibration analysismodel for cables with sag and bending stiffness显示文摘 | Ricciardi G Saitta F | 2008 | En-gineering Structures2008，30，： | 1 |
| 10 | Photovoltaic properties of multi-walled carbon nanotubes deposited on n-doped silicon 显示文摘 | Arena A Donato N Saitta G | 2008 | Microelectron J2008，39，12： | 1 |
| 11 | Randomized, double-blind, placebo-controlled study on effects of raloxifene and hormone replacement therapy on plasma NO concentration, endothelin 1 levels, and endothelium-dependent vasodilation in postmenopausal women 显示文摘 | Saitta A | 2001 | Arterioscler Thromb Vasc Biol2001，21，： | 1 |
| 12 | Effectiveness of nebulized hypertonie saline and epinephrine in hospitalized infants with bronehiolitis 显示文摘 | Miraglia DGM Saitta F Leonardi S | 2012 | Int J Immunopathol Pharmaeol2012，25，2： | 1 |
| 13 | Serum thyroid autoantibodies in patients with didopathic either acute or chronic urticatia 显示文摘 | Guangemi S Saitta S Lombardo G | 2009 | Endocrinol Invest2009，32，2： | 1 |
| 14 | Plasma leptin,insulin,and neuropeptide Y concentrations in infants显示文摘 | Manganaro R Saitta G | 2005 | Arch Dis Child Fetal Neonatal Ed2005，90，1： | 1 |
| 15 | Evidence for a role of nuclear faetor-kappaB in acute hypovolem ic hemorrhagic shock显示文摘 | Altavilla D Saitta A Squadrito G | 2002 | Surgery2002，131，1： | 1 |
| 16 | A continuous vibration analysis model for cables with sag and bending stiffness显示文摘 | Ricciardi G Saitta F | 2008 | Engineering Structures2008，30，： | 1 |
| 17 | Gas Chromatografic Determination of Azoxystrobin,Dinocap,Fenarimol,Penconazole and Quinoxyfen During Wine-making显示文摘 | Di Bella G Saitta M Salvo F | 2003 | Italian Journal of Food Science2003，15，3： | 1 |
| 18 | Data mining techniques for improving the reliability of system identification 显示文摘 | SAiTTA S RAPHAEL B SMITH F C | 2005 | Advanced Engineering Informatics2005，19，4： | 1 |
| 19 | Evidence for a role of nuclear factor-kappa B in acute hypovolemic hemorrhagic shock显示文摘 | Altavilla D Saitta A Squadrito G | 2002 | Surgery2002，131，： | 1 |
| 20 | Evidence for a role of nuclear factor-kappaB in acute hypovolemic hemorrhagic shock 显示文摘 | Ahavilla D Saitta A Squadfito G | 2002 | Surgery2002，131，1： | 1 |
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