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| 1 | 基于机器视觉的苹果外观缺陷在线检测显示文摘为了能够在分选中正确地检测出表面存在缺陷的水果,提高苹果的分级水平,设计了一套基于机器视觉技术检测水果外观缺陷的系统。该系统主要包括单通道在线传送装置、图像采集装置及分选装置,其中图像采集装置的硬件主要包括一个加有635 nm滤光片的CCD相机和两面平面镜。基于VS2010平台开发了在线控制软件。苹果在传送装置上旋转前行过程中,相机在3个位置上采集包含平面镜中镜像在内的单个样品的9个不同角度的图像信息。利用数字处理方法分析苹果表面的缺陷,提出利用面积比来判断水果缺陷大小。实验结果表明苹果表面缺陷的总检测正确率为92.5%。 | 赵娟 彭彦昆 Sagar Dhakal 张雷蕾 | 2013 | 农业机械学报2013，44，S1： | 43 |
| 2 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 3 | 生鲜猪肉主要品质参数无损在线检测系统显示文摘基于可见近红外光谱技术,设计了生鲜猪肉品质无损在线检测装置。介绍了该系统的工作原理、工作过程、硬件组成及软件系统功能。系统硬件包括光谱信息采集装置、样品传送单元、位置检测单元、控制单元和计算机等。基于Delphi和Matlab语言开发了与PC硬件和Windows XP软件环境兼容的光谱信息自动采集和实时处理的无损在线检测软件系统。该系统可实现生鲜猪肉样品光谱数据的自动采集、光谱数据的在线处理、样品品质参数的在线预测与检测结果的在线显示。将该系统用于生鲜猪肉水分含量的在线检测。结果表明,该在线检测装置检测精度高、可靠性好,可用于肉品主要品质参数的无损在线检测。 | 张海云 彭彦昆 王伟 赵松玮 Sagar Dhakal | 2013 | 农业机械学报2013，44，4： | 23 |
| 4 | 基于拉曼光谱的苹果中农药残留种类识别及浓度预测的研究显示文摘应用拉曼光谱技术结合化学计量学方法能有效的实现果蔬中农药残留的定性定量分析。本研究借助实验室自主研发的拉曼光谱检测系统,对苹果中溴氰菊酯和啶虫脒的快速无损识别和检测进行了探索。定性分析时将拉曼峰574和843cm-1分别作为识别溴氰菊酯和啶虫脒的拉曼指纹,当苹果中的溴氰菊酯和啶虫脒残留的含量分别为0.78和0.15mg·kg-1时,两种农药的特征峰仍清晰可见。定量分析首先对光谱进行多种预处理(Savitzky-Golay平滑、一阶导、二阶导、基线校准、标准正态变量变换),结合偏最小二乘法分别建立苹果中溴氰菊酯和啶虫脒含量的定量模型。结果表明,采用8次多项式拟合进行基线校准的预处理方法效果最好,对于溴氰菊酯,偏最小二乘模型预测值与气相色谱法测定值的相关系数和预测均方根误差分别为0.94和0.55mg·kg-1,对于啶虫脒,其偏最小二乘模型的相关系数与预测均方根误差分别为0.85和0.12mg·kg-1。本研究证实了利用拉曼技术对苹果农残进行无损检测的可行性,使用该方法进行检测时,在光谱测定前不需要进行前处理,光谱测定后样品无任何损伤,该技术实现了果蔬农残的现场检测,可在检测部门、果蔬加工企业、超市、市场等场所得到推广使用,为果蔬品质安全提供了一种无损、快速和环保的检测方法。 | 翟晨 彭彦昆 李永玉 DHAKAL Sagar 徐田锋 郭浪花 | 2015 | 光谱学与光谱分析2015，35，8： | 23 |
| 5 | The Ozone Component of Global Change:Potential Effects on Agricultural and Horticultural Plant Yield,Product Quality and Interactions with Invasive Species显示文摘The productivity,product quality and competitive ability of important agricultural and horticultural plants in many regions of the world may be adversely affected by current and anticipated concentrations of ground-level ozone(O3).Exposure to elevated O3 typically results in suppressed photosynthesis,accelerated senescence,decreased growth and lower yields.Various approaches used to evaluate O3 effects generally concur that current yield losses range from 5% to 15% among sensitive plants.There is,how-ever,considerable genetic variability in plant responses to O3.To illustrate this,we show that ambient O3 concentrations in the eastern United States cause substantially different levels of damage to otherwise similar snap bean cultivars.Largely undesirable effects of O3 can also occur in seed and fruit chemistry as well as in forage nutritive value,with consequences for animal production.Ozone may alter herbicide efficacy and foster estab-lishment of some invasive species.We conclude that current and projected levels of O3 in many regions worldwide are toxic to sensitive plants of agricultural and horticultural significance.Plant breeding that incorporates O3 sensitivity into selection strategies will be increasingly necessary to achieve sustainable production with changing atmospheric composition,while reductions in O3 precursor emissions will likely benefit world food pro-duction and reduce atmospheric concentrations of an important greenhouse gas. | Fitzgerald Booker Russell Muntifering Margaret McGrath Kent Burkey Dennis Decoteau Edwin Fiscus William Manning Sagar Krupa Arthur Chappelka David Grantz | 2009 | Journal of Integrative Plant Biology2009，51，4： | 18 |
| 6 | 澜沧江和怒江流域的气候变化及其对径流的影响显示文摘采用VIP(Vegetation Interface Processes)模型和HIMS(Hydro-Informatic Modeling System)模型,模拟分析了1957—2012年澜沧江和怒江流域(简称两江流域)水资源量的演变。根据CMIP5 RCP2.6,RCP4.5和RCP8.5情景预测,模拟了2030年代和2050年代流域水资源的变化。研究发现,过去50年间,两江流域的气温都呈升高趋势,但海拔较高的上游地区升幅大于下游。年总降水量的变化趋势不明显,但春季降水增加趋势明显。两江流域年总水资源量为650亿~850亿m^3,水资源总量长期变化趋势不明显,其中澜沧江的波动性(1.884,最大与最小之比)大于怒江。空间上水资源量呈现北低-南高的格局。在未来,两江流域气温仍呈增加趋势,降水呈增加趋势,径流呈增加趋势,空间变异性趋小,但较强的季节性变化对水资源安全仍具有较大的挑战性。 | 刘苏峡 丁文浩 莫兴国 王盛 刘昌明 罗贤 何大明 Sagar Ratna Bajracharya Arun Bhakta Shrestha Nand Kishor Agrawal | 2017 | 气候变化研究进展2017，13，4： | 17 |
| 7 | Treatment of pediatric femoral shaft fractures by stainless steel and titanium elastic nail system: A randomized comparative trial显示文摘 | Tank Gyaneshwar Rustagi Nitesh Tomar Sagar Kothiyal Pranav Nitesh Rustagi | 2016 | Chinese Journal of Traumatology2016，19，4： | 12 |
| 8 | Advances in surgical management for locally recurrent rectal cancer: How far have we come?显示文摘Locally recurrent rectal cancer(LRRC) is a complex disease with far-reaching implications for the patient. Until recently, research was limited regarding surgical techniques that can increase the ability to perform an en bloc resection with negative margins. This has changed in recent years and therefore outcomes for these patients have improved. Novel radical techniques and adjuncts allow for more radical resections thereby improving the chance of negative resection margins and outcomes. In the past contraindications to surgery included anterior involvement of the pubic bone, sacral invasions above the level of S2/S3 and lateral pelvic wall involvement. However, current data suggests that previously unresectable cases may now be feasible with novel techniques, surgical approaches and reconstructive surgery. The publications to date have only reported small patient pools with the research conducted by highly specialised units. Moreover, the short and long-term oncological outcomes are currently under review. Therefore although surgical options for LRRC have expanded significantly, one should balance the treatment choices available against the morbidity associated with the procedure and select the right patient for it. | Daniel Jin-Keat Lee Peter M Sagar Gaitri Sadadcharam Kok-Yang Tan | 2017 | World Journal of Gastroenterology2017，23，23： | 12 |
| 9 | Gait Recognition by Cross Wavelet Transform and Graph Model显示文摘In this paper, a multi-view gait based human recognition system using the fusion of two kinds of features is proposed.We use cross wavelet transform to extract dynamic feature and bipartite graph model to extract static feature which are coefficients of quadrature mirror filter(QMF)-graph wavelet filter bank. Feature fusion is done after normalization. For normalization of features, min-max rule is used and mean-variance method is used to find weights for normalized features. Euclidean distance between each feature vector and center of the cluster which is obtained by k-means clustering is used as similarity measure in Bayesian framework. Experiments performed on widely used CASIA B gait database show that, the fusion of these two feature sets preserve discriminant information. We report 99.90 % average recognition rate. | Sagar Arun More Pramod Jagan Deore | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，3： | 8 |
| 10 | Carcinogenesis on the background of liver fibrosis: Implications for the management of hepatocellular cancer显示文摘Hepatocellular carcinoma(HCC) is now the second leading cause of cancer-related deaths globally and many patients have incurable disease. HCC predominantly occurs in the setting of liver cirrhosis and is a paradigm for inflammation-induced cancer. The causes of chronic liver disease promote the development of transformed or premalignant hepatocytes and predisposes to the development of HCC. For HCC to grow and progress it is now clear that it requires an immunosuppressive niche within the fibrogenic microenvironment of cirrhosis. The rationale for targeting this immunosuppression is supported by responses seen in recent trials with checkpoint inhibitors. With the impact of immunotherapy, HCC progression may be delayed and long term durable responses may be seen. This makes the management of the underlying liver cirrhosis in HCC even more crucial as studies demonstrate that measures of liver function are a major prognostic factor in HCC. In this review, we discuss the development of cancer in the setting of liver inflammation and fibrosis, reviewing the microenvironment that leads to this tumourigenic climate and the implications this has for patient management. | Joanne Marie O'Rourke Vandana Mridhu Sagar Tahir Shah Shishir Shetty | 2018 | World Journal of Gastroenterology2018，24，39： | 8 |
| 11 | 儿童颌骨骨髓炎的多层CT表现显示文摘目的探讨多层CT(MSCT)在诊断儿童颌骨骨髓炎中的价值。方法 10例儿童颌骨骨髓炎病例术前均实施MSCT扫描,对MSCT数据进行图像后处理,分析其MSCT征象。结果 10例患儿中男4例、女6例。病变均发生于下颌骨的下颌角、下颌支。MSCT影像学征象包括:10例中9例出现骨质破坏;均可见较广泛的骨质增生硬化;全部病例可见与颌骨平行的骨膜新生骨;2例追踪复查,病变颌骨可重新塑形;10例中8例合并了周围的蜂窝组织炎。结论 MSCT可在术前正确诊断儿童颌骨骨髓炎,对于选择合适的临床治疗方式至关重要。 | 符水 范淼 陈丹 Sagar Pandey 常丹丹 杨智云 | 2016 | 中华口腔医学研究杂志(电子版)2016，10，4： | 6 |
| 12 | Ileal-anal pouches: A review of its history, indications, and complications显示文摘The ileal pouch anal anastomosis(IPAA)has revolutionised the surgical management of ulcerative colitis(UC)and familial adenomatous polyposis(FAP).Despite refinement in surgical technique(s)and patient selection,IPAA can be associated with significant morbidity.As the IPAA celebrated its 40th anniversary in 2018,this review provides a timely outline of its history,indications,and complications.IPAA has undergone significant modification since 1978.For both UC and FAP,IPAA surgery aims to definitively cure disease and prevent malignant degeneration,while providing adequate continence and avoiding a permanent stoma.The majority of patients experience long-term success,but“early”and“late”complications are recognised.Pelvic sepsis is a common early complication with far-reaching consequences of long-term pouch dysfunction,but prompt intervention(either radiological or surgical)reduces the risk of pouch failure.Even in the absence of sepsis,pouch dysfunction is a longterm complication that may have a myriad of causes.Pouchitis is a common cause that remains incompletely understood and difficult to manage at times.10%of patients succumb to the diagnosis of pouch failure,which is traditionally associated with the need for pouch excision.This review provides a timely outline of the history,indications,and complications associated with IPAA.Patient selection remains key,and contraindications exist for this surgery.A structured management plan is vital to the successful management of complications following pouch surgery. | Kheng-Seong Ng Simon Joseph Gonsalves Peter Michael Sagar | 2019 | World Journal of Gastroenterology2019，25，31： | 6 |
| 13 | Mechanisms of triglyceride metabolism in patients with bile acid diarrhea显示文摘Bile acids(BAs) are essential for the absorption of lipids. BA synthesis is inhibited through intestinal farnesoid X receptor(FXR) activity. BA sequestration is known to influence BA metabolism and control serum lipid concentrations. Animal data has demonstrated a regulatory role for the FXR in triglyceride metabolism. FXR inhibits hepatic lipogenesis by inhibiting the expression of sterol regulatory element binding protein 1c via small heterodimer primer activity. Conversely, FXR promotes free fatty acids oxidation by inducing the expression of peroxisome proliferator-activated receptor α. FXR can reduce the expression of microsomal triglyceride transfer protein, which regulates the assembly of very low-density lipoproteins(VLDL). FXR activation in turn promotes the clearance of circulating triglycerides by inducing apolipoprotein C-Ⅱ, very low-density lipoproteins receptor(VLDL-R) and the expression of Syndecan-1 together with the repression of apolipoprotein C-Ⅲ, which increases lipoprotein lipase activity. There is currently minimal clinical data on triglyceride metabolism in patients with bile acid diarrhoea(BAD). Emerging data suggests that a third of patients with BAD have hypertriglyceridemia. Further research is required to establish the risk of hypertriglyceridaemia in patients with BAD and elicit the mechanisms behind this, allowing for targeted treatment. | Nidhi Midhu Sagar Michael McFarlane Chuka Nwokolo Karna Dev Bardhan Ramesh Pulendran Arasaradnam | 2016 | World Journal of Gastroenterology2016，22，30： | 5 |
| 14 | Safety and efficacy of endoscopic colonic stenting as a bridge to surgery in the management of intestinal obstruction due to left colon and rectal cancer: A systematic review and meta-analysis显示文摘 | Roberto Cirocchi Eriberto Farinella Stefano Trastulli Jacopo Desiderio Chiara Listorti Carlo Boselli Amilcare Parisi Giuseppe Noya Jayesh Sagar | 2012 | Surgical Oncology2012，，： | 4 |
| 15 | Traumatic cardiac injury: Experience from a level-1 trauma centre显示文摘 | Biplab Mishra Amit Gupta Sushma Sagar Maneesh Singhal Subodh Kumar | 2016 | Chinese Journal of Traumatology2016，19，6： | 4 |
| 16 | Comparison of selective flocculation of low grade goethitic iron ore fines using natural and synthetic polymers and a graft copolymer显示文摘This study aims to beneficiate low grade goethitic iron ore fines using a selective flocculation process. Selective flocculation studies were conducted using different polymers such as starch amylopectin(AP), poly acrylic acid(PAA), and a graft copolymer(AP-g-PAA). The obtained results were analyzed; they indicate the enhancement of the iron ore grade from 58.49% to 67.52% using AP-g-PAA with a recovery of 95.08%. In addition, 64.45% Fe with a recovery of 88.79% was obtained using AP. Similarly, using PAA, the grade increased to 63.46% Fe with a recovery of 82.10%. The findings are also supported by characterizing concentrates using X-ray diffraction(XRD) and electron probe microanalysis(EPMA) techniques. | Kichakeswari Tudu Sagar Pal N.R.Mandre | 2018 | International Journal of Minerals,Metallurgy and Materials2018，25，5： | 4 |
| 17 | Extrusion–spheronization a promising pelletization technique: In-depth review显示文摘This review article deals with various aspects of the extrusion–spheronization technique.The first part includes different steps in the production process of pellets such as granulation, extrusion, spheronization, and drying. In the second part, the parameters which can influence the quality of pellets including formulation(moisture content, granulating liquid,excipients, and drugs), equipment(mixer, extruder, friction plate, and extrusion screen) and process(extrusion speed, extrusion temperature, spheronizer load, spheronization time,spheronization speed, and drying method) are discussed. In the final part, methods available for characterization(particle size distribution, surface area, shape and sphericity, porosity,density, hardness and friability, flow properties, disintegration, and dissolution) of the pellets are explained. | Sagar Muley Tanaji Nandgude Sushilkumar Poddar | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，6： | 3 |
| 18 | Exploiting Natural Variation in Tomato to Define Pathway Structure and Metabolic Regulation of Fruit Polyphenolics in the Lycopersicum Complex显示文摘While the structures of plant primary metabolic pathways are generally well defined and highly conserved across species,those defining specialized metabolism are less well characterized and more highly variable across species.In this study,we investigated polyphenolic metabolism in the lycopersicum complex by characterizing the underlying biosynthetic and decorative reactions that constitute the metabolic network of polyphenols across eight different species of tomato.For this purpose,GC-MS-and LC-MS-based metabolomics of different tissues of Solatium lycopersicum and wild tomato species were carried out,in concert with the evaluation of cross-hybridized microarray data for MapMan-based transcriptomic analysis,and publicly available RNA-sequencing data for annotation of biosynthetic genes.The combined data were used to compile species-specific metabolic networks of polyphenolic metabolism,allowing the establishment of an entire pan-species biosynthetic framework as well as annotation of the functions of decoration enzymes involved in the formation of metabolic diversity of the flavonoid pathway.The combined results are discussed in the context of the current understanding of tomato flavonol biosynthesis as well as a global view of metabolic shifts during fruit ripening.Our results provide an example as to how large-scale biology approaches can be used for the definition and refinement of large specialized metabolism pathways. | Takayuki Tohge Federico Scossa Regina Wendenburg Pierre Frasse llse Balbo Mutsumi Watanabe Saleh Alseekh Sagar Sudam Jadhav Jay C.Delfin Marc Lohse Patrick Giavalisco Bjoern Usadel Youjun Zhang Jie Luo Mondher Bouzayen Alisdair R.Fernie | 2020 | Molecular Plant2020，13，7： | 3 |
| 19 | Effect of Cation Proportion on the Structural and Magnetic Properties of Ni-Zn Ferrites Nano-Size Particles Prepared By Co-Precipitation Technique显示文摘有一般公式 Ni 1−x Zn x Fe 2 有 x = 的 O 4 0.0, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6,和 0.7 被湿化学一起沉淀准备方法。结构并且磁性借助于 X 光检查衍射,磁化,和交流危险性大小被学习。X 光检查分析证实了样品的单相的形成。从 XRD 数据获得的格子参数被发现与 Zn 内容 x 增加。阳离子分发被 X 光检查紧张比率计算学习。磁化结果展出在同一直线上的含铁为 x ≤
的磁性的结构0.4,并且哪个的变化为 x>0.4 非在同一直线上。居里温度 T 从交流危险性数据获得的 C 与增加 x 减少。 | Santosh S. Jadhav Sagar E. Shirsath B. G. Toksha S. J. Shukla K. M. Jadhav | 2008 | Chinese Journal of Chemical Physics2008，21，4： | 3 |
| 20 | 外加磁场对SPIO-shRNA分子探针用于活体荷瘤裸鼠卵巢癌肿瘤MR成像的影响显示文摘目的:探讨外加磁场对SPIO-sh RNA分子探针用于活体荷瘤裸鼠卵巢癌肿瘤MR成像的影响。方法:设定探针注射浓度为含铁18 mg/kg,扫描时间为探针注射后27 h;将30只BALB/c荷瘤裸鼠随机分为3组,即磁转染组(实验组),探针转染组(阴性对照组),荷瘤裸鼠组(空白对照组),每组样本量分别为10只荷瘤裸鼠,并在扫描前对磁转染组行外加磁场处理。采用磁共振MR扫描检测裸鼠体内肿瘤组织及邻近肌肉组织信号强度变化;每次检查完成后立即处死裸鼠,取出肿瘤组织及肌肉组织行HE、普鲁士蓝染色,并在光学显微镜下观察。结果:T1WI序列各组间肿瘤组织信号强度差异不具有统计学意义(F=2.623,P=0.091),各组间肌肉组织信号强度差异不具有统计学意义(F=0.434,P=0.652);T2WI及T2*序列磁转染组及探针转染组肿瘤组织信号强度较荷瘤裸鼠组减低,差异具有统计学意义(P=0.000),且磁转染组较探针转染组差异更显著,差异具有统计学意义(P=0.000);而T2*序列磁转染组肌肉组织信号强度较其余组信号减低,差异具有统计学意义(P=0.000);HE染色显示各组肿瘤组织结构紊乱,细胞核异型性增多;普鲁士蓝染色表明在磁转染组和探针转染组中均存在蓝染铁颗粒,且磁转染组蓝染颗粒更为丰富。结论:外加磁场能够诱导SPIO-sh RNA分子探针靶向作用于卵巢癌肿瘤组织并提高肿瘤组织摄取的有效浓度。 | 廖蕤堃 曾丹妮 Sagar Thapa 文明 | 2018 | 重庆医科大学学报2018，43，3： | 2 |
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