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| 1 | Endoscopic ultrasound-guided vs endoscopic retrograde cholangiopancreatography biliary drainage for obstructed distal malignant biliary strictures: A systematic review and meta-analysis显示文摘BACKGROUND For palliation of malignant biliary obstruction(MBO), the gold-standard method of biliary drainage is endoscopic retrograde cholangiopancreatography(ERCP)with the placement of metallic stents. Endoscopic ultrasound(EUS)-guided drainage is an alternative that is typically reserved for cases of ERCP failure.Recently, however, there have been robust randomized clinical trials(RCTs)comparing EUS-guided drainage and ERCP as primary approaches to MBO.AIM To compare EUS guidance and ERCP in terms of their effectiveness and safety in palliative biliary drainage for MBO.METHODS This was a systematic review and meta-analysis, in which we searched the MEDLINE, Excerpta Medica, and Cochrane Central Register of Controlled Trials databases. Only RCTs comparing EUS and ERCP for primary drainage of MBO were eligible. All of the studies selected provided data regarding the rates of technical and clinical success, as well as the duration of the procedure, adverse events, and stent patency. We assessed the risk of biases using the Jadad score and the quality of evidence using the Grading of Recommendations Assessment,Development and Evaluation criteria.RESULTS The database searches yielded 5920 records, from which we selected 3 RCTs involving a total of 222 patients(112 submitted to EUS and 110 submitted to ERCP). In the EUS and ERCP groups, the rate of technical success was 91.96%n and 91.81%, respectively, with a risk difference(RD) of 0.00%(95%CI:-0.07, 0.07;P = 0.97; I^2 = 0%). The clinical success was 84.81% and 85.53% in the EUS and ERCP groups, respectively, with an RD of-0.01%(95%CI:-0.12, 0.10; P = 0.90; I^2 =0%). The mean difference(MD) for the duration of the procedure was-0.12%(95%CI:-8.20, 7.97; P = 0.98; I^2 = 84%). In the EUS and ERCP groups, there were14 and 25 adverse events, respectively, with an RD of-0.06%(95%CI:-0.23, 0.12; P= 0.54; I^2 = 77%). The MD for stent patency was 9.32%(95%CI:-4.53, 23.18; P =0.19; I^2 = 44%). The stent dysfunction rate was significantly lower in the EUS t group(MD =-0.22%; 95 CI:-0.35,-0.08; P = 0.001; I^2 = 0%).CONCLUSION EUS represents an interesting alternative to ERCP for MBO drainage,demonstrating lower stent dysfunction rates compared with ERCP. Technical and clinical success, duration, adverse events and patency rates were similar. | Fernanda P Logiudice Wanderlei M Bernardo Facundo Galetti Vitor M Sagae Carolina O Matsubayashi Antonio C Madruga Neto Vitor O Brunaldi Diogo T H de Moura Tomazo Franzini Spencer Cheng Sergio E Matuguma Eduardo G H de Moura | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，4： | 6 |
| 2 | Establishment and characterization of a breast cancer cell line expressing Na+/I-symporter for radioiodide concentrator gene therapy显示文摘 | Nakamato Y Saga T Misaki T | 2000 | J Nucl Med2000，41，： | 2 |
| 3 | Phase II study of S-1,docetaxeland cisplatin combination chemotherapy in patients with unresect-abale metastic gastric cancer显示文摘 | Satou Y Takayama T Saga T | 2008 | Proc ASCO2008，26，： | 1 |
| 4 | Evaluation of primary brain tumors with FLT-PET:usefulness and limitations显示文摘 | Saga T Kawashima H Araki N | 2006 | Clin Nucl Med2006，31，12： | 1 |
| 5 | Delayed cardiac tamponade caused by self-inserted needles显示文摘 | Inoue T Iemura J Saga T | | 0，，： | 1 |
| 6 | Downregula- tion of vasohibin- 2, a novel a- ngiogenesis regulator, suppresses tumor growth by inhibiting angiogenesis in end - ometrial cancer cells 显示文摘 | Koyanagi T Saga Y Takahashi Y | 2013 | Oncol Lett2013，5，3： | 1 |
| 7 | Clinical value of positron emission tomography with FDG for recurrent ovarian cancer显示文摘 | Nakamoto Y Saga T Ishimori T | 2001 | AJR Am J Roentgenol2001，176，： | 1 |
| 8 | Adrenocorticaladenoma containing a fat component : CT and MR imageevaluation 显示文摘 | Sato N Watanabe Y Saga T | 1995 | Abdom Imaging1995，20，5： | 1 |
| 9 | Enhancement of the therapeutic outcome of radio-immunotherapy by combination with wholebody mild hyperthermia显示文摘 | Saga T Sakahara H Nakamoto Y | 2001 | Eur J Cancer2001，3711，： | 1 |
| 10 | FDG- PET of autoimmune-related pancreatitis: preliminary results 显示文摘 | NAKAMOTO Y SAGA T ISHIMORI T | 2000 | Eur J Nucl Med2000，27，12： | 1 |
| 11 | The potential clinical value of FDG-PET for recurrent renal cell carcinoma显示文摘 | Nakatani K Nakamoto Y Saga T | 2011 | Eur J Radiol2011，79，1： | 1 |
| 12 | Functional analysis of Shigella VirG domains essential for interaction with vinculin and actin-based motility显示文摘 | Suzuki T Saga S Sasakawa C | 1996 | J Biol Chem1996，271，21： | 1 |
| 13 | Enhancement of the therapeutic outcome of radio-immunotherapy by combination with wholebody mild hyperthermia显示文摘 | Saga T Sakahara H Nakamoto Y | 2001 | Eur J Cancer2001，37，： | 1 |
| 14 | Postradiation dennato- fibrosarcoma protuberans 显示文摘 | Kamiya T Saga K Kaneko R | 2006 | Acta Derm Venereol2006，86，2： | 1 |
| 15 | Anatomical study of the vertebral artery in Japanese adults显示文摘 | Yamaki K Saga T Hirata T | | 0，，： | 1 |
| 16 | Novel liver macromolecular MR contrast agent with a polypropylenimine diaminobutyl dendrimer core: comparison to the vascular MR contrast agent with the polyamidoamine dendrimer core 显示文摘 | Kobayashi H Kawamoto S Saga T | 2001 | Magn Reson Med2001，46，4： | 1 |
| 17 | Dynamic micro- magnetic resonance imaging of liver mierometastasis in mice with a novel liver macromolecular magnetic resonance contrast agent DAB-Am64-(1B4M-Gd)(64) 显示文摘 | Kobayashi H Saga T Kawamoto S | 2001 | Cancer Res2001，61，13： | 1 |
| 18 | Self-assembly of synthetic zinc chlorines in silicate micelle prepared by sol-gel processs显示文摘 | Saga Y Miyatake T Tamiaki H | 2002 | Bioorg Med Chem Lett2002，12，： | 1 |
| 19 | Self-assembly of synthetic zinc chlorines in silicate micelle prepared by sol-gel processs 显示文摘 | Saga Y Miyatake T Tamiaki H | 2002 | Bioorg Med Chem Lett2002，12，： | 1 |
| 20 | Diffusion-weighted MR imaging of uterine endometrial cancer显示文摘 | Tamai K Koyama T Saga T | 2007 | J Magn Reson Imaging2007，26，3： | 1 |
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