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| 1 | ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10(ABCC1O) are not primary resistance factors for cabazitaxel显示文摘Introduction:ATP-binding cassette subfamily B member 1(ABCB1) and subfamily C member 10(ABCCIO) proteins are efflux transporters that couple the energy derived from ATP hydrolysis to the translocation of toxic substances and chemotherapeutic drugs out of cells.Cabazitaxel is a novel taxane that differs from paclitaxel by its lower affinity for ATP-binding cassette(ABC) transporters.Methods:We determined the effects of cabazitaxel,a novel tubulin-binding taxane,and paclitaxel on paclitaxelresistant,ABCB1-overexpressing KB-C2 and LLC-MDR1-WT cells and paclitaxel-resistant,ABCC10-overexpressing HEK293/ABCC10 cells by calculating the degree of drug resistance and measuring ATPase activity of the ABCB1 transporter.Results:Decreased resistance to cabazitaxel compared with paclitaxel was observed in KB-C2,LLC-MDR1-WT,and HEK293/ABCC10 cells.Moreover,cabazitaxel had low efficacy,whereas paclitaxel had high efficacy in stimulating the ATPase activity of ABCB1,indicating a direct interaction of both drugs with the transporter.Conclusion:ABCB1 and ABCC10 are not primary resistance factors for cabazitaxel compared with paclitaxel,suggesting that cabazitaxel may have a low affinity for these efflux transporters. | Rishil J Kathawala Yi-Jun Wang Suneet Shukla Yun-Kai Zhang Saeed Alqahtani Amal Kaddoumi Suresh V Ambudkar Charles R Ashby Jr Zhe-Sheng Chen | 2015 | Chinese Journal of Cancer2015，34，3： | 4 |
| 2 | Gastric intestinal metaplas a: subtypes and natural history 显示文摘 | El-Zimaitv H M Ramchatesingh J Saeed M A | 2001 | J Clin Pathol2001，54，9： | 1 |
| 3 | TM4: a free, opensource system for microarray data management and analysis 显示文摘 | Saeed A Sharov V White J | 2003 | Biotechniques2003，34，2： | 1 |
| 4 | Vitrification and rapid freezing of rabbit fatal tissues and skin samples from rabbits and pigs 显示文摘 | SILVESTRE M A SAEED A M ESCRIBA M J | 2002 | Theriogenology2002，58，： | 1 |
| 5 | Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells显示文摘 | SAEED M SCHEEL T K GOTrWEIN J M | 2012 | Antimicrub Agents and Chemoth- erpay2012，56，10： | 1 |
| 6 | TM4: A free, open-source system for microarray data management and analysis显示文摘 | Saeed AI Sharov V White J | 2003 | Biotechniques2003，，2： | 1 |
| 7 | Association of Gprotein beta-3 subunit gene ( GNB3 ) T825 allele with Type Ⅱ diabetes显示文摘 | KIANI J G SAEED M PARVEZ S H | 2005 | Neuro Endocrinol Lett2005，26，2： | 1 |
| 8 | Optic nerve sheath meningiomas显示文摘 | Saeed P Rootman J Nugent RA | 2003 | Opthalmology2003，110，10： | 1 |
| 9 | Myocardial ischaemia and reperfusion injury:reactive oxygen species and the role of neutrophil 显示文摘 | Saeed S A Waqar M A Zubairi A J | 2005 | J Coil Physicians Surg Pak2005，15，8： | 1 |
| 10 | Vitrification and rapid freezing of rabbit fetal tissues and skin samples from rabbits and pigs显示文摘 | SILVESTRE M A SAEED A M ESCRIBA M J | 2002 | Theriogenology2002，58，1： | 1 |
| 11 | An ALMT1 gene cluster controlling alumimLm tolerance at the Alt4 locus of rye (Secale cerealeL) 显示文摘 | Collins N C Shirley N J Saeed M | 2008 | Genetics2008，179，1： | 1 |
| 12 | Modular construc- tion of multifunctional bioresponsive cell-targeted nanoparti- cles for gene delivery 显示文摘 | Saeed A O Magnusson J P Moradi E | 2011 | Bioconjugate Chem2011，22，： | 1 |
| 13 | Noncompaction of the left ven- tricular myocardium显示文摘 | Saeed S vcqsundvaq J lode I | 2009 | Tidsskr Nor Laegeforen2009，129，11： | 1 |
| 14 | Targeting epidermal growth factor receptors and downstream signaling pathways in cancer by phytochemicals显示文摘 | Kadioglu O Cao J Saeed M E M | 2015 | Targeted Oncology2015，10，3： | 1 |
| 15 | Prediction of toxicity of nitrebenzenes using AB initio and least squares support vector machines 显示文摘 | NIAZI A SAEED J B DAVOOD N S | 2008 | Journal of Hazardous Materials2008，151，23： | 1 |
| 16 | Whole tissue hydrogen sulfide concentrations are orders of magnitude lower than presently accepted values显示文摘 | Fume J Saeed A Levitt MD | | 0，，05： | 1 |
| 17 | Helminths of red foxes (Vulpes vulpes) in Denmark显示文摘 | Saeed I Maddox-Hyttel C Monrad J | 2006 | Vet Parasitol2006，139，13： | 1 |
| 18 | Myocardial ischaemia and reperfusion injury: reactive oxygen species and the role of neutrophil显示文摘 | Saeed S A Waqar M A Zubairi A J | 2005 | J Coil Physicians Surg Pak2005，15，8： | 1 |
| 19 | Comparison of intrale- sional corticosteroid and propranolol treatment of periorbital infantile hemangiomas: an outcome study of 61 cases 显示文摘 | Hoornweg M J Saeed P Tanck MW | 2014 | Eur J Ophthalmol2014，24，6： | 1 |
| 20 | Preparation of electronspun carbon nanofibers of carbon nanotube/polycaprolactone (MWNT/PCL) nanocomposite 显示文摘 | Saeed K Park S Y Lee H J | 2006 | Polymer2006，47，： | 1 |
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