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| 1 | Serum bicarbonate may independently predict acute kidney injury in critically ill patients:An observational study显示文摘AIM: To explore whether serum bicarbonate at admission to intensive care unit(ICU) predicted development of acute kidney injury(AKI).METHODS:We studied all patients admitted to our ICU over a 2 year period(February 2010 to 2012).The ICU has a case mix of medical and surgical patients excluding cardiac surgical,trauma and neurosurgical patients.We analysed 2035 consecutive patients admitted to ICU during the study period.Data were collected by two investigators independently and in duplicate using a standardised spread sheet to ensure accuracy.Ambiguous data were checked for accuracy where indicated.AKI was defined using the Kidney Disease Improving Global Outcomes criteria.Patients were divided into two groups;patients who developed AKI or those who did not,in order to compare the baseline characteristics,and laboratory and physiologic data of the two cohorts.Regression analysis was used to identify if serum bicarbonate on admission predicted the development of AKI.RESULTS:Of 2036 patients 152(7.5%)were excluded due to missing data.AKI developed in 43.1%of the patients.The AKI group,compared to the nonAKI group,was sicker based on their lower systolic,diastolic and mean arterial pressures and a higher acutephysiology and chronic health evaluation(APACHE)Ⅲand SAPSⅡscores.Moreover,patients who developed AKI had more co-morbidities and a higher proportion of patients who developed AKI required mechanical ventilation.The multi-regression analysis of independent variables showed that serum bicarbonate on admission(OR=0.821;95%CI:0.796-0.846;P<0.0001),APACHEⅢ(OR=1.011;95%CI:1.007-1.015;P<0.0001),age(OR=1.016;95%CI:1.008-1.024;P<0.0001)and presence of sepsis at ICU admission(OR=2.819;95%CI:2.122-23.744;P=0.004)were each significant independent predictors of AKI.The area under the ROC curve was 0.8(95%CI:0.78-0.83),thereby demonstrating that the predictive model has relatively good discriminating power for predicting AKI.CONCLUSION:Serum bicarbonate on admission may independently be used to make a diagnosis of AKI. | Anuksha Gujadhur Ravindranath Tiruvoipati Elizabeth Cole Saada Malouf Erum Sahid Ansari Kim Wong | 2015 | World Journal of Critical Care Medicine2015，4，1： | 3 |
| 2 | Pseudo-static stability analysis of rock slopes reinforced by passive bolts using the generalized Hoek-Brown criterion显示文摘The stability analysis of passive bolt-reinforced rock slopes under seismic loads is investigated within the framework of the kinematic approach of limit analysis theory.A pseudo-static method is adopted to account for the inertial forces induced in the rock mass by seismic events.The strength properties of the rock material are described by a modified Hoek-Brown strength criterion,whereas the passive bolts are modeled as bar-like inclusions that exhibit only resistance to tensile-compressive forces.Taking advantage of the ability to compute closed-form expressions for the support functions associated with the modified Hoek-Brown strength criterion,a rotational failure mechanism is implemented to derive rigorous lower bound estimates for the amount of reinforcement strength to prevent slope failure.The approach is then applied to investigating the effects of relevant geometry,strength and loading parameters in light of a preliminary parametric study.The accuracy of the approach is assessed by comparison of the lower bound estimates with finite element limit analysis solutions,thus emphasizing the ability of the approach to properly predict the stability conditions and to capture the essential features of deformation localization pattern.Finally,the extension of the approach to account for slipping at the interface between reinforcements and surrounding rock mass is outlined. | Mounir Belghali Zied Saada Denis Garnier Samir Maghous | 2017 | Journal of Rock Mechanics and Geotechnical Engineering2017，9，4： | 2 |
| 3 | Cracks, bifurcation and shear bands propagation in saturated clays显示文摘 | Saada A S Bianchini G F Liang L Q | 1994 | Geotechnique1994，44，1： | 1 |
| 4 | Integrat- ed probabilistic framework for domino effect and risk analysis 显示文摘 | Nguyen Q B Mebarki A Saada R A | 2009 | Advances in Engineering Software2009，，40： | 1 |
| 5 | Effectiveness of Aloe vera on the antioxidant status of different tissues in irradiated rats显示文摘 | Saada HN Ussama ZS Mahdy AM | 2003 | Pharmazie2003，58，12： | 1 |
| 6 | Influence of Heavy Organic Pollutants of Anthropic Origin on PAH Retention by Kaolinite显示文摘 | GABORIAU H SAADA A | 2001 | Chemosphere2001，44，7： | 1 |
| 7 | RheologyAnd photo-cross-linking of thiol-ene polymers 显示文摘 | Bor-Sen C English R J SaadA K | 1996 | Macromolecules1996，29，16： | 1 |
| 8 | Micromechanisms of deformation in fracture of over consolidated clays显示文摘 | CHUDNOVSKY A SAADA A J | | 0，，： | 1 |
| 9 | Real-time FTIRAnd in situ rheological studies on the UV curing kinetics of thiol-ene polymers显示文摘 | Bor-Sen C SaadA K | 1997 | Macromolecules1997，30，23： | 1 |
| 10 | An Extended model for the analysis of the dynamic behavior of planetary trains显示文摘 | Saada A Velex P | 1995 | ASME Journal of Mechanical Design1995，117，6： | 1 |
| 11 | Integrated probabilistic framework for domino effect and risk analysis显示文摘 | Nguyen Q B Mebarki A Saada R A | 2009 | Advances in Engineering Software2009，40，9： | 1 |
| 12 | Peripheral nerve injury induces Schwann cells to express two macrophage phenotypes: phagocytosis and the galactose-specific lectin MAC-2显示文摘 | Reichert F Saada A Rotshenker S | 1994 | J Neurosci1994，14，52： | 1 |
| 13 | Mesenchymal cells of the intestinal lamina propria 显示文摘 | Powell DW Pinchuk IV Saada JI | 2011 | Annu Rev Physiol2011，73，： | 1 |
| 14 | A quality control program for acute pain management in out-of-hospital critical care medicine显示文摘 | RicardHibon A Chollet C Saada S | 1999 | Ann Emerg Med1999，34，8： | 1 |
| 15 | Oral treatment with laquinimod augments regulatory T-cells and brain-derived neurotrophic factor expression and reduces injury in the CNS of mice with experimental autoimmune encephalomyelitis显示文摘 | Rina Aharoni Ravit Saada Raya Eilam Liat Hayardeny Michael Sela Ruth Arnon | 2012 | Journal of Neuroimmunology (-)2012，，1： | 1 |
| 16 | Influence of heavy organic pollutants of anthrop icorigin on PAH retention by kaolinite显示文摘 | Gabor I H Saada A | 2001 | Chemosphere2001，44，7： | 1 |
| 17 | Computer simulation of damage in diamond due to ion impact and its annealing 显示文摘 | Saada D Adler J Kalish R | 1999 | Phys Rev B1999，59，10： | 1 |
| 18 | Mitochondrial respiratory enzymes are a major target of iron toxicity in rat heart cells显示文摘 | Link G Saada A Pinson A | 1998 | Lab Clin Med1998，131，5： | 1 |
| 19 | The influence of pH, electrolyte type, and surface coating on arsenate (Ⅴ) adsorption onto kaolinites显示文摘 | Comu S Breeze D Saada A | 2003 | Soil Science Society of American Journal2003，67，： | 1 |
| 20 | Physical modeling of tunnels in soft ground显示文摘 | Meguid M A Saada O Nunes M A | 2008 | Tunneling and Underground Space Technology2008，23，： | 1 |
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