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| 1 | Drug eluting biliary stents to decrease stent failure rates:Areview of the literature显示文摘Biliary stenting is clinically effective in relieving both malignant and non-malignant obstructions. However, there are high failure rates associated with tumor ingrowth and epithelial overgrowth as well as internally from biofilm development and subsequent clogging. Within the last decade, the use of prophylactic drug eluting stents as a means to reduce stent failure has been investigated. In this review we provide an overview of the current research on drug eluting biliary stents. While there is limited human trial data regarding the clinical benefit of drug eluting biliary stents in preventing stent obstruction, recent research suggests promise regarding their safety and potential efficacy. | Joseph Shatzel Jisoo Kim Kartik Sampath Sharjeel Syed Jennifer Saad Zilla H Hussain Kabir Mody J Marc Pipas Stuart Gordon Timothy Gardner Richard I Rothstein | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 6 |
| 2 | Visual and refractive outcomes of posterior chamber phakic IOL in stable keratoconus显示文摘We evaluated the visual and refractive outcomes after phakic visian toric implantable collamer lens(ICL) insertion in stable keratoconus(KC). This retrospective study investigated toric ICL implantation in 14 eyes of 8 patients with stable KC. After 6 mo, the mean uncorrected distance visual acuity improved significantly from 0.77 to 0.15 logMAR. The mean best corrected distance visual acuity(BCDVA) improved from 0.18±0.1 to 0.15±0.1 logMAR. Fifty percent of eyes maintained their preoperative BCDVA; 42.8% gained one line. There was no statistical difference in high order or coma aberration. The mean refractive manifest spherical equivalent(MSE), mean refractive manifest spherical error, mean manifest astigmatism decreased significantly postoperatively. At 6 mo postoperatively, our achieved mean spherical equivalent was approximately 74%. No intraoperative or postoperative complications occurred. Toric ICL implantation was effective, predictable and safe to correct refractive error and improve visual acuity in patients with stable KC. | Sherif H Emerah Moataz M Sabry Hisham A Saad Waleed A Ghobashy | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 2 |
| 3 | Quantification of epicardial fat:Which method can predict significant coronary artery disease?显示文摘AIM:To compare the predictive value of three methods of epicardial fat(EF) assessment for presence of significant coronary artery disease(CAD) [i.e.,epicardial fat volume(EFV),EFV indexed with body surface area(EFV/BSA) and EFV indexed with body mass index(EFV/BMI)].METHODS:The study was performed on 170 patients(85 women and 85 men) with clinical suspicion of CAD.They aged 26-89 years with a median age of 54 years.The patients were classified into three groups:Group 1:58 patients with normal coronary arteries; group 2:48 patients with non-significant CAD and group 3:64 patients with significant CAD.The three methods for assessment of epicardial fat were retrospectively studied to determine the best method to predict the presence of significant CAD.RESULTS:The three methods for epicardial fat quantification and measurements,i.e.,EFV,EFV/BSA and EFV/BMI with post- hoc analysis showed a significant difference between patients with significant coronary artery disease compared to the normal group.Receiver operating characteristic curve analysis showed no significant difference between the three methods of epicardial fat measurements,the area under curve ranging between 0.6 and 0.62.The optimal cut-off was 80.3 cm3 for EFV,2.4 cm3/m2 for EFV indexed with BMI and 41.7 cm3/(kg/m2) for EFV indexed with BSA.For this cut-off the sensitivity ranged between 0.92 and 0.94,while specificity varied from 0.31 to 0.35.CONCLUSION:Any one of the three methods for assessment of epicardial fat can be used to predict significant CAD since all have the same equivalent predictive value. | Zizi Saad Mohamed El-Rawy Ragab H Donkol Sami Boghattas | 2015 | World Journal of Cardiology2015，7，5： | 2 |
| 4 | Pre-treatment role of inosine triphosphate pyrophosphatase polymorphism for predicting anemia in Egyptian hepatitis C virus patients显示文摘AIM: To investigate and clarify, for the first time, the role of inosine triphosphate pyrophosphatase (ITPA ) polymorphism in Egyptian chronic hepatitis C virus (HCV) patients.METHODS:The human genomic DNA of all patients was extracted from peripheral blood cells in order to determine the single nucleotide polymorphism (SNP) of ITPA (rs1127354). SNP genotyping was performed by real time polymerase chain reaction (PCR, ABI TaqMan allelic discrimination kit) for 102 treatment-naive Egyptian patients with chronic HCV. All patients had no evidence of cardiovascular or renal diseases. They received a combination treatment of pegylated interferon α (PEG-IFNα) as a weekly subcutaneous dose plus an oral weight-adjusted dose of ribavirin (RBV). The majority received PEG-IFNα2a (70.6%) while 29.4% received PEG-IFNα2b. The planned duration of treatment was 24-48 wk according to the viral kinetics throughout the course of treatment. Pre-treatment liver biopsy was done for each patient for evaluation of fibrosis stage and liver disease activity. The basal viral load level was detected quantitatively by real time PCR while viral load throughout the treatment course was performed qualitatively by COBAS TaqMan assay. RESULTS: Ninety-three patients (91.2%) had ITPA SNP CC genotype and 9 (8.8%) had non-CC genotype (CA and AA). The percentage of hemoglobin (Hb) decline was higher for CC patients than for non-CC patients, particularly at weeks 4 and 8 (P=0.047 and 0.034, respectively). During the first 12 wk of treatment, CC patients had significantly more Hb decline > 3 g/dL than non-CC patients: 64.5% vs 22.2% at weeks 8 and 12, respectively, (P=0.024 and 0.038). Reduction of the amount of the planned RBV dose was significantly higher for CC patients than non-CC patients during the first 12 wk (18% ± 12.1% vs 8.5% ± 10.2%, P=0.021). The percentage of CC patients with RBV dose reduction was significantly greater than that of non-CC patients (77.4% vs 44.4%, P=0.044). Multivariate analysis identified only the percentage of RBV dose as a predictor for Hb decline. Platelet decline was significantly higher in non-CC patients than CC patients at weeks 12, 24 and 48 (P=0.018, 0.009 and 0.026, respectively). CONCLUSION: Rs1127354 ITPA polymorphism plays a decisive role in protecting against treatment-induced anemia and the need for RBV dose reduction in Egyptian HCV patients. | Walaa H Ahmed Norihiro Furusyo Saad Zaky Abeer Sharaf Eldin Hany Aboalam Eiichi Ogawa Masayuki Murata Jun Hayashi | 2013 | World Journal of Gastroenterology2013，19，9： | 2 |
| 5 | Gmres: a generalized mini- mal residual algorithm for solving nonsymmetric linear systems显示文摘 | SAAD Y SCHULTZ M H | 1986 | SIAM Journal on Scientific and Statisti- cal Computing1986，7，： | 1 |
| 6 | Hollow fiber liquid-phase microextraction coupled with gas chromatography-flame ionization detection for the profiling of fatty acids in vegetable oils显示文摘 | SIANG G H MAKAHLEH A SAAD B | 2010 | Journal of Chromatography A2010，1217，52： | 1 |
| 7 | 6-Min walk- test data in severe obstructive-sleep-apnea-hypopnea-syndrome ( OSAHS ) under continuous-positive-airway-pressure ( CPAP ) treatment显示文摘 | Ben Saad H Ben Hassen I Ghannouchi I | 2015 | Respiratory Medicine2015，109，5： | 1 |
| 8 | Successful treatment of Kasabach-Merritt syndrome with vineristine and surgery: a case report and review of literature 显示文摘 | Abass K Saad H Kherala M | 2008 | Case J2008，1，1： | 1 |
| 9 | GMRES:a generalized minimal residual algorithm for solving nonsymmetric linear systems显示文摘 | SAAD Y SCHULTZ H | 1986 | SIAM J Sci Statist Comput1986，7，3： | 1 |
| 10 | Classification of molten pool modes in variable polaa~ity plasma arc welding based on acoustic signature 显示文摘 | Saad E Wang H J Kovacevic R | 2006 | Journal of Materials Processing Technology2006，174，1： | 1 |
| 11 | GMRES:a generalized minimal residual algorithm for solving nonsymmetric linear systems显示文摘 | Saad Y Schultz M H | 1986 | Comput Appl Math1986，7，： | 1 |
| 12 | Determination of Metformin in Pharmaceutical Preparations Using Potentiometry,Spectrofluorimetry and UV-visible Spectrophotometry显示文摘 | Saad S M Hassan Wagiha H Mahmoud Mohamed A F Elmosallamy | 1999 | Anal Chim Acta1999，378，13： | 1 |
| 13 | Nitric oxide and its role during pregnancy:from ovulation to delivery显示文摘 | MAUL H LONGO M SAADE G R al | 2003 | 2003,9(5):359-3802003，9，5： | 1 |
| 14 | GMRES:A generalized minimal residual algorithm for solving nonsymmetric linear systems 显示文摘 | YOUCEF SAAD MARTIN H SCHULTZ | 1986 | Society for Industrial and Applied Mathematics1986，7，3： | 1 |
| 15 | The potential of mid- dle eastern flora as a source of new safe bio-acaricides to control Tetranychus cinnabarinus ,the carmine spider mite 显示文摘 | Mansour F Azaizeh H Saad B | 2004 | Phytoparasitica2004，32，1： | 1 |
| 16 | Nitric oxide and its role during pregnancy: from ovulation to delivery显示文摘 | Maul H Longo M Saade GR | 2003 | Curr Pharm Des2003，9，5： | 1 |
| 17 | GMRES:A generalized minimal residual algorithm for solving non-symmetric linear systems显示文摘 | Y Saad M H Schultz | | 0，，03： | 1 |
| 18 | Intensive care unit-acquired stenotrophomonas maltophilia:Incidence,risk factors and outcome显示文摘 | Saad N Christophe DP Hélène B | 2006 | Critical Care2006，10，： | 1 |
| 19 | Electrodeposition of selenium,indium and copper in an air-and water-stable ionic liquid at variable temperatures显示文摘 | Zein El Abedin S Saad A Y Farag H K | 2007 | Electrochimica Acta2007，52，8： | 1 |
| 20 | Ordering fuzzy sets over the real line: an approach based on decision making under uncertainty 显示文摘 | Saade J Schwarzlander H | 1992 | Fuzzy Sets and Systems1992，，50： | 1 |
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