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| 1 | Epstein-Barr virus and nasopharyngeal carcinoma显示文摘Since its discovery 50 years ago,Epstein-Barr virus(EBV)has been linked to the development of cancers originating from both lymphoid and epithelial cells.Approximately 95%of the world’s population sustains an asymptomatic,life-long infection with EBV.The virus persists in the memory B-cell pool of normal healthy individuals,and any disruption of this interaction results in virus-associated B-cell tumors.The association of EBV with epithelial cell tumors,specifically nasopharyngeal carcinoma(NPC)and EBVpositive gastric carcinoma(EBV-GC),is less clear and is currently thought to be caused by the aberrant establishment of virus latency in epithelial cells that display premalignant genetic changes.Although the precise role of EBV in the carcinogenic process is currently poorly understood,the presence of the virus in all tumor cells provides opportunities for developing novel therapeutic and diagnostic approaches.The study of EBV and its role in carcinomas continues to provide insight into the carcinogenic process that is relevant to a broader understanding of tumor pathogenesis and to the development of targeted cancer therapies. | Lawrence S.Young Christopher W.Dawson | 2014 | Chinese Journal of Cancer2014，33，12： | 30 |
| 2 | Single-cell transcriptomic analysis defines the interplay between tumor cells,viral infection,and the microenvironment in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an Epstein-Barr virus(EBV)-associated malignancy with a complex tumor ecosystem.How the interplay between tumor cells,EBV,and the microenvironment contributes to NPC progression and immune evasion remains unclear.Here we performed single-cell RNA sequencing on^104,000 cells from 19 EBV^+NPCs and 7 nonmalignant nasopharyngeal biopsies,simultaneously profiling the transcriptomes of malignant cells,EBV,stromal and immune cells.Overall,we identified global upregulation of interferon responses in the multicellular ecosystem of NPC.Notably,an epithelial–immune dual feature of malignant cells was discovered and associated with poor prognosis.Functional experiments revealed that tumor cells with this dual feature exhibited a higher capacity for tumorigenesis.Further characterization of the cellular components of the tumor microenvironment(TME)and their interactions with tumor cells revealed that the dual feature of tumor cells was positively correlated with the expression of co-inhibitory receptors on CD8^+tumor-infiltrating T cells.In addition,tumor cells with the dual feature were found to repress IFN-γproduction by T cells,demonstrating their capacity for immune suppression.Our results provide new insights into the multicellular ecosystem of NPC and offer important clinical implications. | Shanzhao Jin Ruoyan Li Ming-Yuan Chen Chao Yu Lin-Quan Tang Yan-Min Liu Jiang-Ping Li Yi-Na Liu Yi-Ling Luo Yifan Zhao Yu Zhang Tian-Liang Xia Shang-Xin Liu Qi Liu Guan-Nan Wang Rui You Jing-Yun Peng Jiang Li Feng Han Jianwei Wang Qiu-Yan Chen Li Zhang Hai-Qiang Mai Benjamin E.Gewurz Bo Zhao Lawrence S.Young Qian Zhong Fan Bai Mu-Sheng Zeng | 2020 | Cell Research2020，30，11： | 16 |
| 3 | Detecting Earnings Management using Cross-Sectional Abnormal Accruals Models显示文摘 | Peasnel K.V P.F.Pope S.Young | | 0，，04： | 1 |
| 4 | Epstein-Barr virus at 50——future perspectives显示文摘The special November and December issues of the Chinese Journal of Cancer celebrate the 50th anniversary of the discovery of Epstein-Barr virus(EBV) with a series of reviews covering the association of the virus with various cancers, with special emphasis on the role of EBV in the pathogenesis of nasopharyngeal cancer(NPC). The restricted geographic prevalence of NPC along with the tumor's consistent association with EBV infection has fascinated scientists and clinicians ever since it was first suggested in 1966. As in all cancers, NPC development reflects the complex interplay between host genes and environmental factors, but the essential role of EBV infection provides important insight into the etiology of this tumor. Indeed, it is this understanding that is now translating into exciting diagnostic and therapeutic opportunities. | Lawrence S.Young | 2014 | Chinese Journal of Cancer2014，33，11： | 1 |
| 5 | Treatment of severe aplastic anaemia with combined immunosuppression: anti‐thymocyte globulin, ciclosporin and mycophenolate mofetil显示文摘 | PhillipScheinberg OlgaNunez ColinWu Neal S.Young | 2006 | British Journal of Haematology2006，，6： | 1 |
| 6 | The Link Between Earnings Timeliness,Earnings Conservatism and Board Composition:evidence from the UK显示文摘 | Beekes W P.Pope S.Young | | 0，，： | 1 |
| 7 | Board Monitoring and Earnings Management:Do Outside Directors Influence Abnormal Accruals显示文摘 | K.V.Peasnell P.F.pope S.young | | 0，，32： | 1 |
| 8 | 第19章 中尺度行星边界层气象学研究100年进步显示文摘本章描述了我们对直接与地表驱动联系在一起的中尺度大气环流几个例子的认识过程,从海洋热力驱动变化和向陆地传播,到人为温度和粗糙度改变,最后是强迫边界层环流。例子包括大气对以下要素的响应:(1)海洋温度变化;(2)海岸线(海风);(3)内陆水域中尺度区域(湖泊效应风暴);(4)陆地表面利用变化(城市用地覆盖)。本章简要总结这些中尺度大气环流以及认识它们的工具的历史演变,它们对领域的重要意义,以及开启和决定其演变的物理过程,同时给出我们预感的未来研究的关键途径。美国气象学会(AMS)在促进中尺度地表驱动环流发展方面发挥了直接和重要的作用。AMS期刊出版物和学术会议对该领域和相关大气、海洋和水文领域,以及姊妹科技组织的作用,通过广泛的引文展示出来。 | 大卫·克里斯托维奇 EUGENE TAKLE GEORGE S.YOUNG ASHISH SHARMA 贾朋群(编译) 李婧华(编译) | 2019 | 气象科技进展2019，9，S01： | 0 |
| 9 | A novel Epstein-Barr virus subtype associated with nasopharyngeal carcinoma found in South China显示文摘Nasopharyngeal carcinoma(NPC)is a unique malignancy closely associated with Epstein-Barr virus(EBV)infection and with a restricted geographical distribution[1].According to a recent World Health Organization(WHO)report,there were around 129,000 new NPC cases reported worldwide in 2018 with greater than 70%of cases in South China and Southeast Asia[2].In Hong Kong and Guangdong in South China,NPC incidence is as high as 12.8-25.0/100,000 per year[1,2]. | Lawrence S.Young | 2020 | Cancer Communications2020，40，1： | 0 |
| 10 | 试管牙齿显示文摘牙齿是一个精细的器官,比人们实际看到的要复杂得多.如果组织工程师能够制造出有活力的替换牙,在引导牙科进入再生医学领域的同时,也将揭开工程化大器官的序幕. | Paul T.Sharpe Conan S.Young 郭伟 谢卫红 | 2005 | 科学(中文版)2005，，10： | 0 |
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