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| 1 | Antiphospholipid syndrome:a clinical perspective显示文摘Antiphospholipid syndrome (APS) is a thromboinflammatory disease with a variety of clinical phenotypes. Primary thrombosis prophylaxis should take an individualized risk stratification approach. Moderate-intensity vitamin K antagonist such as warfarin remains the primary strategy for secondary thrombosis prophylaxis among APS patients, especially for patients with predominantly venous disease. For now, direct oral anti-coagulants should be avoided in most APS patients, especially those with history of arterial manifestations. Obstetric APS management should be tailored based on an individual patient’s antiphospholipid antibody profile, and obstetric and thrombotic history. Pharmacological agents beyond anticoagulants may be considered for the management of microthrombotic and nonthrombotic manifestations of APS, although more data are needed. A relatively recent discovery in the area of APS pathogenesis is the implication of neutrophil extracellular traps in thrombin generation and initiation of inflammatory cascades. APS is a complex thromboinflammatory disease with a broad clinical spectrum. Personalized therapy according to an individual’s unique thrombosis and obstetric risk should be advocated. | Yu Zuo Hui Shi Chun Li Jason S.Knight | 2020 | Chinese Medical Journal2020，，8： | 4 |
| 2 | Topical diltiazem ointment in the treatment of chronic anal fissure显示文摘 | J. S.Knight M.Birks R.Farouk | 2002 | Br J Surg2002，，4： | 1 |
| 3 | 小流域管理策略——大流域生态和经济可持续发展管理的组成部分显示文摘面对土地和水资源等多方面的需求,如何维持河流的良性生态环境,资源管理者要面临众多挑战。为保证流域生态系统的健康和可持续性,必须用一整套被证明了的、科学的管理原则对流域进行管理。美国农业部农业服务研究中心水质和生态研究所对为小流域土地和水资源管理提供怎样的管理策略和管理办法产生了兴趣。研究认为,应关注大江大河(包括黄河在内)的水系网络,包括应用小流域尺度的工程和非工程保护措施、适当的监测水平及相应的监测项目和土水资源利用的决策体系等办法。通过开展拦蓄水资源、改善水质以及环境所能提供的水量等方面的研究,提供了水土保持、水流流向控制的成功例子:水资源的短期拦蓄能够为当地提供所需的水资源,改善水质;而长期拦蓄能够为下游的生态和经济提供水量支持。为在保护流域环境的同时促进流域可持续发展,需要能证明目前环境和生态发生变化测定指标方面的知识。针对特定蓄水区、利用各种有效保护措施的动态小流域管理能够促进大流域内旱地和水生生态系统的保护。 | Charles M.Cooper F.Douglas Shields Jr.Scott S.Knight | 2005 | 人民黄河2005，27，11： | 0 |
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