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| 1 | 百奥明:2012年全球霉菌毒素调查报告显示文摘致读者:多年来,霉菌毒素领域的科学家们一直致力于发展更快速、更可靠和更经济的分析方法,从而能够扩宽霉菌毒素的鉴别范围。作为这项研究的成果,一种多霉菌毒素分析方法目前已可应用,它可在45 min内分析一种原料或饲料样品,应用精确的液相—质谱联用分析仪能够鉴别出超过320种不同的霉菌毒素,其中包括常规分析方法无法检测到的隐蔽的和结合的霉菌毒素。 | Inês Rodrigues Karin Naehrer 张艳 王金勇 | 2013 | 中国畜牧杂志2013，49，14： | 11 |
| 2 | Helicobacter pylori and EBV in gastric carcinomas:Methylation status and microsatellite instability显示文摘AIM:To verify the methylation status of CDH1, DAPK, COX2, hMLH1 and CDKN2A genes and to evaluate their association with Helicobacter pylori (H. pylori)-cagA+ and Epstein Barr virus (EBV) infections in gastric adenocarcinomas.METHODS: Methylation-specific PCR (MSP) assay was performed in 89 primary gastric carcinomas (intestinal and diffuse types). Microsatellite instability (MSI) analysis was performed using the BAT26 primer set and PCR products were analyzed with the ABI PRISM 3100 Genetic Analyzer using Genescan 3.7 software (Applied Biosystems). Detection of H. pylori and genotyping were performed by PCR, using specifi c primers for ureaseC and cagA genes. The presence of EBV was assessed by in situ hybridization. Statistical analyses were performed using the χ2 or Fisher's exact test.RESULTS: The most frequent hypermethylated gene was COX-2 (63.5%) followed by DAPK (55.7%), CDH1 (51%), CDKN2A (36%) and hMLH1 (30.3%). Intestinal and diffuse adenocarcinomas showed different methylation profiles and there was an association between methylation of E-CDH1 and H. pylori-cagA+ in the intestinal adenocarcinoma type. MSI was correlated with hMLH1 methylation. There was an inverse correlation between DAPK hypermethylation and MSI.CONCLUSION: We found a strong association between CDH1 methylation and H. pylori-cagA+ in intestinal-type gastric cancer, association of MSI and better prognosis and an heterogeneous COX-2 overexpression. | Adriana Camargo Ferrasi Nídia Alice Pinheiro Silvia Helena Barem Rabenhorst Otávia Luisa Caballero Maria Aparecida Marchesan Rodrigues Fabrício de Carvalho Celso Vieira de Souza Leite Marcia Valéria Pitombeira Ferreira Marcos Aurélio Pessoa Barros Maria Inês de Moura Campos Pardini | 2010 | World Journal of Gastroenterology2010，16，3： | 6 |
| 3 | Polysaccharide-based nanomedicines for cancer immunotherapy:A review显示文摘Cancer immunotherapy is an effective antitumor approach through activating immune systems to eradicate tumors by immunotherapeutics.However,direct administration of“naked”immunotherapeutic agents(such as nucleic acids,cytokines,adjuvants or antigens without delivery vehicles)often results in:(1)an unsatisfactory efficacy due to suboptimal pharmacokinetics;(2)strong toxic and side effects due to low targeting(or off-target)efficiency.To overcome these shortcomings,a series of polysaccharide-based nanoparticles have been developed to carry immunotherapeutics to enhance antitumor immune responses with reduced toxicity and side effects.Polysaccharides are a family of natural polymers that hold unique physicochemical and biological properties,as they could interact with immune system to stimulate an enhanced immune response.Their structures offer versatility in synthesizing multifunctional nanocomposites,which could be chemically modified to achieve high stability and bioavailability for delivering therapeutics into tumor tissues.This review aims to highlight recent advances in polysaccharide-based nanomedicines for cancer immunotherapy and propose new perspectives on the use of polysaccharide-based immunotherapeutics. | Yujun Zeng Yufan Xiang Ruilong Sheng Helena Tomás João Rodrigues Zhongwei Gu Hu Zhang Qiyong Gong Kui Luo | 2021 | Bioactive Materials2021，6，10： | 3 |
| 4 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 5 | Effect of biofeedback accompanying occupational therapy and functional electrical stimulation in hemiplegic patients显示文摘 | Maria Inês Paes Louren??o Linamara Rizzo Battistella Christina May Moran de Brito Gracinda Rodrigues Tsukimoto Margarida Harumi Miyazaki | 2008 | International Journal of Rehabilitation Research2008，，1： | 2 |
| 6 | Abscisic acid inhibits type 2C protein phosphatases via the PYR/ PYL family of START proteins显示文摘 | PARK S Y FUNG P NISHIMURA N JENSEN D R FFUJII ZHAO Y LUMBA S SANTIAGO J RODRIGUES A CHOW T F | 2009 | Science2009，324，： | 1 |
| 7 | Activation of cellular invasion by trefoil peptides and src is mediated by cyclooxygenase-2 and thromboxane A2 receptor-dependent signaling pathways显示文摘 | Rodrigues S Nguyen QD Faivre S | 2001 | FASEB J2001，15，9： | 1 |
| 8 | Crk I and Crk Ⅱ funtion as key signaling integrators for migration and invasion of cancer cells显示文摘 | Rodrigues S P Fathers K E Chan G | 2005 | Mol Cancer Res2005，3，4： | 1 |
| 9 | Response surface analysis and sinulation as tool for bioprocess design and optimization显示文摘 | Kalil S J Maugeri F Rodrigues M I | 2000 | Process Biochemistry2000，35，6： | 1 |
| 10 | lmmunophenotypic characterization of peripheral T lymphocytes in Mycobacterium tuberculo- sis infection and disease显示文摘 | Rodrigues D S Medeiros E A Weckx L Y | 2002 | Clin Exp Immunol2002，128，1： | 1 |
| 11 | Preparation and morphology of polypropylene/wood flour composite foams via extrusion显示文摘 | Zhang S W Rodrigue D | 2005 | PolymerComposites2005，26，6： | 1 |
| 12 | Efficacy and safety of apretinin use for reoperative valvular surgery 显示文摘 | Rodrigues AJ Evora PR Bassetto S a al | 2007 | Ann Thorac Surg2007，83，6： | 1 |
| 13 | Viscoelasticdamping technologies, part I: Modeling and finite elementimplementation 显示文摘 | Vasques C M A * Moreira R A S Rodrigues J D | 2010 | Journal of Advanced Research inMechanical Engineering2010，1，2： | 1 |
| 14 | Optimization of the production of biodiesel from soybean oil by ultrasound assisted methanolysis显示文摘 | SANTOS F F P RODRIGUES S FERNANDES F A N | | 0，，： | 1 |
| 15 | Designing an in- dicator o{ environmental responsibility显示文摘 | Rodrigues J Domingos T Giljum S | 2007 | Ecological Eco- nomics2007，，59： | 1 |
| 16 | 2008年霉菌毒素普查项目报告显示文摘黄曲霉毒素B1、玉米赤霉烯酮、呕吐毒素、烟曲霉毒素、赭曲霉毒素A以及T-2毒素,这些霉菌毒素名称无疑会引起你的警惕,它们是在畜牧生产中最常见、最重要的几种霉菌毒素。尽管这些霉菌毒素是在作物生产周期的不同阶段产生的。玉米赤霉烯酮、烟曲霉毒素和单端孢菌霉烯毒素(呕吐毒素和T-2毒素)等镰刀霉菌毒素主要在田间产生, | DI Inês Rodrigues | 2009 | 今日养猪业2009，，4： | 1 |
| 17 | Trefoil peptides as proangiogenic factors in vivo and in vitro: implication of cyclooxygenase-2 and EGF receptor signaling显示文摘 | Rodrigues S Van Aken E Van Bocxlaer S | 2003 | FASEB J2003，17，1： | 1 |
| 18 | 显示文摘 | Loureiro Jose M Rodrigues Alirio E | 1998 | Journal of Chromatography A1998，827，： | 1 |
| 19 | Piecewise-affine state feedback for piecewise-affine slab systems using convex optimization 显示文摘 | RODRIGUES L BOYD S | 2005 | Systems and Control Letters2005，，54： | 1 |
| 20 | In vitro reconstitution of an abscisic acid signalling pathway显示文摘 | FUJII H CHINNUSAMY V RODRIGUES A RUBIO S AATONI R PARK S Y CUTLER S R SHEEN J ROTRIGUES P L ZHU J K | 2009 | Nature2009，462，： | 1 |
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