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| 1 | Systematic analysis of the safety and benefits of transvaginal hybrid-NOTES cholecystectomy显示文摘AIM: To evaluate transvaginal hybrid-NOTES cholecystectomy(TVC) during its clinical establishment and compare it with the traditional laparoscopic technique(LC).METHODS: The specific problems and benefits of TVC were reviewed using a registry analysis,a comparative cohort study and a randomized clinical trial. At first,feasibility,safety and specific complications of the TVC were analyzed based on the first 488 data sets of the German NOTES Registry(GNR). Hereafter,we compared the early postoperative results of our first 50 TVC-patients with those of 50 female LCpatients matched by age,BMI and ASA classification. The same cohort was contacted an average of two years later to evaluate long-term results concerning pain and satisfaction with the aesthetic results and the overall postoperative results as well as sexual intercourse by means of two domains of the German version of the Female Sexual Function Index(FSFI-d). Consequently,we performed a randomized clinical trial comparing 20 TVC-patients with 20 needlescopic/3-trocar cholecystectomies(NC) also concerning the early postoperative results as well as pain,satisfaction and quality of life by means of the Eypasch Gastrointestinal Quality of Life Index(GIQLI) in the later course. Finally,we discussed the results in accordance with other published studies.RESULTS: The complication(3.5%) and conversion rates(4.1%) for TVC were low in the GNR and comparable to those of the LC. Access related intraoperative complications included injuries to the bladder(n = 4; 0.8%) and bowel(n = 3; 0.6%). The study cohort revealed less postoperative pain after TVC comparing to the LC-patients on the day of surgery(NRS,1.5/10 vs 3.1/10,P = 0.003),in the morning(NRS,1.9/10 vs 2.8/10,P = 0.047) and in the evening(NRS,1.1/10 vs 1.8/10,P = 0.025) of postoperative day(POD) one. The randomized clinical trial consistently found less cumulative pain until POD 2(NRS,8/40 vs 14/40,P = 0.043),as well as until POD 10(NRS,22/190 vs 41/190,P = 0.010). Furthermore,the TVC-patients had a better quality of life on POD 10 than did the LC-patients(GIQLI,124/144 vs 107/144,P = 0.028). The complication rates were comparable and no specific problems were detected in the long-term follow-up for sexual intercourse for either group. The TVC-patients were more satisfied with the aesthetic result in the long-term course in the matched cohort analysis(1.00 vs 1.88,P < 0.001) as well as in the randomized clinical trial(1.00 vs 1.70,P < 0.001) when compared with the LC-patients.CONCLUSION: TVC is a feasible procedure with a high safety profile and has advantages in regard to postoperative pain and aesthetic results when compared with LC or NC. | Dirk R Bulian Jurgen Knuth Kai S Lehmann Axel Sauerwald Markus M Heiss | 2015 | World Journal of Gastroenterology2015，21，38： | 3 |
| 2 | Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct 显示文摘 | Necula M Kayed R Milton S | 2007 | J Biol Chem2007，282，10： | 1 |
| 3 | Identification and characterization of a novel human type Ⅱ diacylglycerol kinase, DGKK显示文摘 | Imai S Kai M Yasuda S | 2005 | Journal of Biological Chemistry2005，280，39： | 1 |
| 4 | Source and tectonic implications of tonalite-trondhjemite magmatism in the Klarnath Mountains 显示文摘 | Barnes C G Petersen S W Kistler R W Murray R Kays M A | 1996 | Contrib Mineral Petrol1996，123，1： | 1 |
| 5 | MMP14 gene polymorphisms in chronic obstructive pulmonary disease显示文摘 | Saitoh W Sakamoto T Hegab A E Nomura A Ishii Y Morishima Y Kai S Iizuka T Kiwamoto T Matsuno Y Massoud H H Massoud H M Hassanein K M Sekizawa K | 2006 | Int J Mol Med2006，17，6： | 1 |
| 6 | Hydrophobic PVDF hollowfiber membranes with narrowpore size distribution and ultra-thin skin for the freshwater produetion through membrane distillation显示文摘 | Wang Kai Yu Chung T S Gryta M | 2008 | Chem Eng Sci2008，63，： | 1 |
| 7 | Schistosoma numsoni triggers dectin-2,whieh activates the Nlrp3 inflammasome and alters adaptive immune responses显示文摘 | Ritter M Gross O Kays S et ol | 2010 | Proc Natl Acad Sci USA2010，107，20： | 1 |
| 8 | Neogene Patagonian plateau lavas: Continental magmas associated with ridge collision at the Chile triple junction 显示文摘 | Gorring M L Kays S M Zeitler P K | 1997 | Tectonics1997，16，： | 1 |
| 9 | Analysis of efficiency of magnetic stimulation显示文摘 | Kai Hsiung Hsu Nagarajan S S Durand D M | 2003 | IEEE Transactions on Biomedical Engineering2003，50，11： | 1 |
| 10 | Mantle processes and sources of Neogene slab window magmas from Southern Patagonia, Argentina显示文摘 | Gorring M L Kays S M | 2001 | Journal of Petrology2001，42，： | 1 |
| 11 | Overexpression of PGC-1α down-regulates GLUT4 mRNA in skeletal muscles显示文摘 | Miura S Kai Y Ono M | 2003 | J Biol Chem2003，278，31： | 1 |
| 12 | Predictor of Asthma Three Years after Hospital Admission for Wheezing in Infancy显示文摘 | Tian M R Annek S Kai K | 2000 | J Pediatr2000，106，6： | 1 |
| 13 | MMP14 gene polymorphisms in chronic obstructive pulmonary disease 显示文摘 | Saitoh W Sakamoto T Hegab A E Nomura A Ishii Y Morishima Y Kai S Iizuka T Kiwamoto T Matsuno Y Massoud H H Massoud H M Hassanein K M Sekizawa K | 2006 | Int J Mol Med2006，17，4： | 1 |
| 14 | n-Hexane neuropathy caused by addictive inhalation: clinical and electrophysiological features显示文摘 | KUWABARA S KAI M R NAGASE H | 1999 | Eur Neurol1999，41，3： | 1 |
| 15 | Small molecular inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct显示文摘 | Necula M Kayed R Milton S | 2007 | J Biol Chem2007，282，10： | 1 |
| 16 | Overexpression of peroxi-some proliferator-activated receptor coactivator-lct down-regulates GLUT4 mRNA in skeletal muscles显示文摘 | Miura S Kai Y Ono M | 2003 | J Biol Chem2003，278，31： | 1 |
| 17 | Regulation of conidiation and adenylyl cyclase levels by the Get protein GNA-3 in Neurospora erassa显示文摘 | Kays A M Rowley P S Baasiri R A | 2000 | Molecular and Cellular Biology2000，20，： | 1 |
| 18 | Skeletal muscle FOXO1(FKHR)transgenic mice have less skeletal muscle mass,down-regulated Type I(slow twitch/red muscle)fiber genes,and impaired glycemic control显示文摘 | Kamei Y Miura S Suzuki M Kai Y Mizukami J Taniguchi T Mochida K Hata T Matsuda J Aburatani H Nishino I Ezaki O | | 0，，39： | 1 |
| 19 | Rapid detection of Mycoplasma pneumoniae in clinical samples by the polymerase chain reaction 显示文摘 | Kai M Kamiya S Yabe H | 1993 | J Med Microbiol1993，38，3： | 1 |
| 20 | Structural and dynamic features of Alzheim-er's Aβpeptide in amyloid fibrils studied by site-directed spin labeling显示文摘 | Tbrbk M Milton S Kayed R | 2002 | J Biol Chem2002，277，40： | 1 |
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