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| 1 | Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review显示文摘BACKGROUND Ameloblastomas are common benign epithelial odontogenic neoplasms that present an aggressive and unpredictable behavior that may modify treatment strategies.Different signaling pathways that participate in the progression of these tumors have been identified.B-raf proto-oncogene serine/threonine kinase(BRAF)is a protein involved in the behavior of ameloblastomas,and it is related to many cell mechanisms.BRAF gene mutations have been identified in ameloblastomas,of which the BRAF V600E(valine substituted by glutamic acid at amino acid 600)mutation has been the most common and can be present concomitantly with other mutations that may be involved in its behavior.Targeted therapies have been used as an alternative in the case of resistance or contraindications to conventional treatments.AIM To document the presence of BRAF V600E and additional mutations,their behavior,and targeted therapies in these tumors.METHODS An electronic literature search was conducted according to PRISMA guidelines in PubMed/MEDLINE,Cochrane,EMBASE,and SpringerLink using the terms“ameloblastomas”,“BRAF V600E”,“additional mutations”,and“targeted therapies”.Ameloblastomas were classified according to WHO guidelines.Inclusion criteria were articles in English,published not more than 10 years ago,and studies with laboratory works related to BRAF V600E.Articles were evaluated by two independent reviewers and retrieved for full-text evaluation.The EBLIP Critical Appraisal Checklist was used to evaluate the quality of the eligible studies.Descriptive statistical analysis was performed.RESULTS Two independent reviewers,with a substantial concordance indicated by a kappa coefficient of k=0.76,evaluated a total of 19 articles that were included in this study.The analysis registered 521 conventional ameloblastomas(AM),81 unicystic ameloblastomas(UA),13 ameloblastic carcinomas(AC),three metastatic ameloblastomas(MA),and six peripheral ameloblastomas(PA),of which the histopathological type,anatomic location,laboratory tests,expression of BRAF mutation,and additional mutations were registered.The BRAF V600E mutation was found in 297 AM(57%),63 UA(77.7%),3 AC(23%),1 MA(50%),and 5 PA(83.3%).Follicular type predominated with a total of 116 cases(40%),followed by plexiform type with 63 cases(22.1%).Furthermore,both types presented additional mutations,in which alterations in JAK3 P132T,SMARCB1,PIK3CA,CTNNB1,SMO,and BRAF G606E genes were found.Four case reports were found with targeted therapy to BRAF V600E.CONCLUSION The identification of BRAF V600E and additional mutations as an aid in targeted therapies has been a breakthrough in alternative treatments of ameloblastomas where surgical treatments are contraindicated. | Rogelio González-González Sandra López-Verdín Jesús Lavalle-Carrasco Nelly Molina-Frechero Mario Isiordia-Espinoza Ramón G Carreón-Burciaga Ronell Bologna-Molina | 2020 | World Journal of Clinical Oncology2020，11，1： | 6 |
| 2 | 通过业余时间运动的中老年的运动心电图:100次运动试验足以确定一个无症状心肌缺血的心脏事件风险显示文摘运动心电图在预防运动员心脏事件方面的重要性一直存在争议。为了确定运动心电图中无症状心肌缺血(silent myocardial ischemia,SMI)的频率及运动心电图与冠状动脉造影评估结果和潜在可预防的心脏事件的关系。Hupin等纳入2011-2014年就诊于Saint-Etienne大学医院运动医学科年龄≥35岁的无症状业余运动员,进行前瞻性队列研究。 | 刘青 叶鹏 Hupin D Edouard P Oriol M Laukkanen J Abraham P Doutreleau S Guy JM CarréF Barthélémy JC Roche F Chatard JC | 2018 | 中华高血压杂志2018，26，4： | 6 |
| 3 | Pretreatment methods to improve sludge anaerobic degradability: A review显示文摘 | H. Carrère C. Dumas A. Battimelli D.J. Batstone J.P. Delgenès J.P. Steyer I. Ferrer | 2010 | Journal of Hazardous Materials2010，，1： | 5 |
| 4 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 5 | Molecular genetics of berry colour variation in table grape显示文摘 | Diego Lijavetzky Leonor Ruiz-García José A. Cabezas María T. Andrés Gemma Bravo Ana Ibá?ez Juan Carre?o Félix Cabello Javier Ibá?ez José M. Martínez-Zapater | 2006 | Molecular Genetics and Genomics2006，，5： | 2 |
| 6 | The comparative effects of Postoperative analgesic therapies on pulmonary outcome: cumulative meta-analyses of randomiIed, controlled trials 显示文摘 | Ballantyne JC Carr DB deFerranti S | 1998 | Anesth Analg1998，86，3： | 1 |
| 7 | Human tryptase fibrinogenolysis is optimal at acidic pH and generates anticoagulant fragments in the presence of the anti - tryptase monoclonal antibody B12显示文摘 | Lawson AE Carr M | 1997 | J Immunol1997，159，7： | 1 |
| 8 | Computed tomographic assessment of fractures of the posterior wall of the acetabulum after operative treatment显示文摘 | Moed B R Willson Carr S E Gruson K I | 2007 | J Bone Joint Surg Am2007，85，3： | 1 |
| 9 | Development and evaluation of sediment quality guidelines for Florida coastal waters显示文摘 | MACDONALD D D CARR R S CALDER F D | 1996 | Ecotoxicology1996，5，： | 1 |
| 10 | Assessment of the novel selective aldosterone blocker eplerenone using ambulatory and clinical bloodpressure in patients with systemic hypertension显示文摘 | White WB Carr AA Krause S | 2003 | Am J Cardiol2003，92，1： | 1 |
| 11 | Battery energy storage technologies显示文摘 | Anderson M D Carr D S | 1993 | Proceedings of the IEEE1993，81，3： | 1 |
| 12 | Correlation of the diame- ter of the left common iliae vein with the risk of lower-ex- tremity deep venous thrombosis 显示文摘 | Carr S Chart K Rosenberg J | 2012 | Vasc Interv Radiol2012，23，11： | 1 |
| 13 | Insights and new direc- tions from demand-side approaches to technology inno- vation, entrepreneurship, and strategic management re- search显示文摘 | Priem R L Li S Carr J C | 2012 | Journal of Management2012，38，1： | 1 |
| 14 | Nanofabrication and electrostatic operation of single- crystal silicon paddle oscillators 显示文摘 | EvoY S CARR D W SEKARIC L | 1999 | Journal of Applied Physics1999，86，： | 1 |
| 15 | Crystal structures of MMP-1 and MMP-13 reveal the structural basis for selectivityof collagenase inhibitors显示文摘 | Welch AR Carr S | 1999 | Nat Struct Biol1999，6，3： | 1 |
| 16 | Endothelial dysfunction: cardiovascular risk factors, therapy, and outcome 显示文摘 | HADI H A CARR C S SUWAIDI J | 2005 | Vasc Health Risk Manag2005，1，3： | 1 |
| 17 | 1-year follow-up of autologous muscle-derived stem cell injection pilot study to treat stress urinary incontinence显示文摘 | Carr LK Steele D Steele S | 2008 | Int Urogynecol J Pelvic Floor Dysfunct2008，19，6： | 1 |
| 18 | Sensitivity analysis for structural errors 显示文摘 | NOWAK A S CARR R I | 1985 | Journal of the structural engineering1985，，8： | 1 |
| 19 | On the Fragility of Skilled Performance:WhatGoverns Choking Under Pressure 显示文摘 | BEILOCK S L CARR T H | 2001 | Journal of Experimental Psychology:General2001，130，4： | 1 |
| 20 | Dipeptidyl peptidase- 1V inhibitor use associated with increased risk of ACE inhibitor-associated angioedema 显示文摘 | Brown N J Byiers S Carr D | 2009 | Hypertension2009，54，3： | 1 |
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