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| 1 | Increased syndecan-1 and glypican-3 predict poor perinatal outcome and treatment resistance in intrahepatic cholestasis显示文摘Background:Intrahepatic cholestasis of pregnancy(ICP)increases the risk of adverse pregnancy outcomes.This study aimed to explore the association between serum syndecan-1 and glypican-3 levels and the adverse perinatal outcome as well as the responses to the treatment of ursodeoxycholic acid(UDCA).Methods:This prospective,case control study included 88 pregnant women(44 women with ICP and 44 healthy controls).The primary end points were the perinatal outcome and the response to UDCA therapy.A logistic regression model was used to identify the independent risk factors of adverse pregnancy outcomes and reduced response to UDCA therapy.Results:Women with ICP had significantly higher serum syndecan-1(1.27±0.36 ng/m L vs.0.98±0.50 ng/m L;P=0.003),glypican-3(1.78±0.13 ng/m L vs.1.69±0.16 ng/m L;P=0.004),AST(128.59±1.44 vs.13.29±1.32 U/L;P<0.001),and ALT(129.84±1.53 vs.8.00±3.67 U/L;P<0.001)levels compared with the controls.The increased levels of syndecan-1(OR=4.715,95%CI:1.554–14.310;P=0.006),glypican-3(OR=8.465,95%CI:3.372–21.248;P=0.007),ALT(OR=1.382,95%CI:1.131–1.690;P=0.002),and postprandial bile acid(PBA)(OR=3.392,95%CI:1.003–12.869;P=0.026)were correlated to ICP.The adverse neonatal outcome was related to increased glypican-3(OR=4.275,95%CI:2.726–5.635;P=0.039),and PBA(OR=3.026,95%CI:1.069–13.569;P=0.037).Increases of syndecan-1(OR=7.464,95%CI:2.130–26.153,P=0.017)and glypican-3(OR=6.194,95%CI:2.951–13.002;P=0.025)were the risk factors of decreased response to UDCA treatment.Conclusion:Syndecan-1 and glypican-3 might be powerful determinants in predicting adverse perinatal outcome in patients with ICP,and they can be used to predict the response to the UDCA treatment. | Basak Gümüs Güler Sibel Ozler | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，3： | 3 |
| 2 | Ultra High Pressure treatment of orange juice:A kinetic study on inactivation of pectin methyl esterase显示文摘 | Basak S Ramaswamy H S | 1996 | Food Research International1996，29，7： | 1 |
| 3 | Value-at-risk-based Risk Management: Optimal Policies and Asset Prices显示文摘 | Basak S Shapiro A | 2001 | Review of Financial Studies2001，14，2： | 1 |
| 4 | Increased dendritic cell number and function following continuous in vivo infusion of granulocyte macrophage-colony-stimulating factor and interleukin-4 显示文摘 | Basak S K Harui A Stolina M | 2002 | Blood2002，99，8： | 1 |
| 5 | A comparative Study of Portfolio Insurance 显示文摘 | Basak S | 2002 | Journal of Economic Dynamics & Control2002，，26： | 1 |
| 6 | An integrated flow reactor- membrane filtration system for heterogeneous photocatalysis part Ⅱ: experiments on the ultrafiltration unit and combined operation 显示文摘 | Soparajee K Qasim S A Basak S | 1999 | J Appl Electrochem1999，29，： | 1 |
| 7 | Ultra high pressure treatment of orange juice: a kinetic study on inactivation of pectin methyl esterase 显示文摘 | Basak S Ramaswamy H S | 1996 | Food Research International1996，29，7： | 1 |
| 8 | Potential use of poly- phenol oxidases (PPO) in the bioremediation of phenolic contam- inants containing industrial wastewater显示文摘 | Mukherjee S Basak B Bhunia B | 2013 | Reviews in Environ- mental Science and Bio/Technology2013，12，： | 1 |
| 9 | Quantitative structure-activity relationship modeling of mosquito repellents using calculated descriptors 显示文摘 | NATATAJAN R BASAK S C MILLS D | 2008 | Croatica Chemica Acta2008，81，2： | 1 |
| 10 | Value-at-Risk-Based risk management: Optimal policies and asset prices显示文摘 | Basak S Shapiro A | 2001 | The Review of Financial Studies Summer2001，14，2： | 1 |
| 11 | ffects of hexose starvation and the role of sialic acid in in?uenza virus release 显示文摘 | Griffin J A Basak S Compans R W | 1983 | Virology1983，125，2： | 1 |
| 12 | Expression and regulation of integrin receptors in human trophoblast cells: role of estradiol and cytokines显示文摘 | DAS C BASAK S | 2003 | Indian J Exp Biol2003，41，7： | 1 |
| 13 | A general equilibrium model of portfolio insurance 显示文摘 | Basak S | 1995 | Review of Financial Studies1995，，： | 1 |
| 14 | Uhraviolet and Visible Photoresponse Properties of n-ZnO/p-Si Heterojunction显示文摘 | Mridha S Basak D | 2007 | Journal of Applied Physics2007，101，08： | 1 |
| 15 | Unsupervised feature evaluation: A neuro-fuzzy approach 显示文摘 | Pal S K De R K Basak J | 2000 | IEEE Transactions on Neural Networks2000，11，2： | 1 |
| 16 | Unsupervised feature evaluation: a neuro-fuzzy approach显示文摘 | PAL S K DE P K BASAK J | 2000 | IEEE Transactions on Neural Networks2000，11，2： | 1 |
| 17 | Steroids modulate the expression of a4 integrin in mouse blastocysts and uterus during implantation显示文摘 | Basak S Dhar R Das C | 2002 | Biol Reprod2002，66，6： | 1 |
| 18 | Crosstalk via the NF-kappaB signaling system显示文摘 | Basak S Hoffmann A | 2008 | Cytokine Growth Factor Rev2008，19，34： | 1 |
| 19 | Ultraviolet and visible photoresponse properties of n-ZnO/p-Si heterojunction 显示文摘 | Mridha S Basak D | 2007 | Journal of Applied Physics2007，101，8： | 1 |
| 20 | Inhibition of proprotein convertases-1 ,- 7 and furin by diterpines of Andrographis paniculata and their succinoyl esters显示文摘 | Basak A Cooper S Roberge A G Banik U K Chretien M Seidah N G | 1999 | Biochem J1999，338，1： | 1 |
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