|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Three-dimensional structural changes in living hippocampal neurons imaged using magnetic AC mode atomic force microscopy.显示文摘 | Yunxu S Danying L Yanfang R Dong H Wanyun M | 2006 | 中国生物学文摘2006，20，9： | 7 |
| 3 | Estrogen-enhanced peptidylarginine deiminase type Ⅳ gene (PADI4) expression in MCF-7 cells is mediated by estrogen receptor-alphapromoted transfactors activator protein-1, nuclear factor-Y, and Spl 显示文摘 | Dong S Zhang Z Takahara H | 2007 | Mol Endocrinol2007，21，7： | 1 |
| 4 | Feelback stabilization via designed planar centre manifold显示文摘 | DONG Y L CHENG D Z QIN H S | 2004 | International Journal of Robust and Nonlinear Control2004，14，1： | 1 |
| 5 | Determination of Sulfur by Molecular Absorption of Carbon Monosulfide Using a High-resolution Continuum Source Absorption Spectrometer and an Air-Acetylene Flame 显示文摘 | Huang Mao Dong Becker-Rossa H Florek S | 2006 | Spectrochimica Acta Part B: Atomic Spectroscopy2006，61，2： | 1 |
| 6 | Relationships Between Protein Composition and Mixograph and Loaf Characteristics in Wheat 显示文摘 | Dong H Sears R G Cox T S | 1992 | Cereal Chem1992，69，2： | 1 |
| 7 | Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays 显示文摘 | MATSUZAKI H DONG S LOI H | 2004 | Nat Methods2004，1，2： | 1 |
| 8 | Critical velocity and burning rate in pool fire during longitudinal ventilation显示文摘 | JAE S R HING S R DONG H K | 2007 | Tunnelling and Underground Space Technology2007，，22： | 1 |
| 9 | GoldBull显示文摘 | Dong S Tang C Zhou H | 2004 | 37(3-4): 1872004，37，34： | 1 |
| 10 | Sol-Gel Synthesis and char- acterization of ytterbium silicate powders显示文摘 | Wen H Dong S He P | 2007 | Journal of the American Ceramic Society2007，90，： | 1 |
| 11 | Overvalued equity and financing decisions 显示文摘 | DONG M HIRSHLEIFER D TEOH S H | 2012 | Review of Financial Studies2012，25，12： | 1 |
| 12 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 13 | Changes in endogenous abscisic acid and soluble sugars levels during dormancy-release in bulbs of Lilium rubellum显示文摘 | Xu R Y Niimi Y Dong S H | 2006 | Scientia Horticulturae2006，111，： | 1 |
| 14 | Apparent protein digestibility and mineral availabilities in various feed ingredients for salmonid feeds显示文摘 | Sugiura S H Dong F M Rathbone C K | 1998 | Aquaculture1998，159，： | 1 |
| 15 | Subcellular co-localization of Arabidopsis RTE1 and ETR1 supports a regulatory role for RTE1 in ETR1 ethylene signaling显示文摘 | Dong C H Rivarola M Resnick J S | 2008 | Plant J2008，53，2： | 1 |
| 16 | Three dimension flow and loss reduction in axial compressors显示文摘 | Dong Y Gallimore S J Hodson H P | 1987 | ASME Journal of Turbomachinecy1987，109，3： | 1 |
| 17 | High solid and high performance UV cured waterborne polyurethanes显示文摘 | Dong H J Kim E Y Kang Y S | 2010 | Collids and Surfaces2010，370，8： | 1 |
| 18 | A cationic fluorocarbon surfactant DEFUMAC1 and its mixed systems with cationic surfactants:^19FNMR and surface tension study 显示文摘 | Dong S L Xu G Y Hoffmann H | 2007 | Phys Chem B2007，111，： | 1 |
| 19 | A C-type lectin associated and translocated with cortical granules during oocyte maturation and egg fertilization in fish显示文摘 | Dong C H Yang S T Yang Z A | 2004 | Dev Biol2004，265，： | 1 |
| 20 | EPR parameters and superposition model analysis for trigonal Dy^3+ O2^- center in CaF2 crystal 显示文摘 | Zheng W C Dong H N Wu S Y | 2004 | Physica B2004，334，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员