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| 1 | Nanoengineered Shear-Thinning Hydrogel Barrier for Preventing Postoperative Abdominal Adhesions显示文摘More than 90%of surgical patients develop postoper-ative adhesions,and the incidence of hospital re-admissions can be as high as 20%.Current adhesion barriers present limited efficacy due to difficulties in application and incompatibility with minimally invasive interventions.To solve thisclinical limitation,we developed an injectable and sprayable shear-thinning hydrogel barrier(STHB)composed of silicate nanoplatelets and poly(ethylene oxide).We optimized this technology to recover mechanical integrity after stress,enabling its delivery though inject-able and sprayable methods.We also demonstrated limited cell adhesion and cytotoxicity to STHB compositions in vitro.The STHB was then tested in a rodent model of peritoneal injury to determine its e cacy preventing the formation of postoperative adhesions.After two weeks,the peritoneal adhesion index was used as a scoring method to determine the formation of postoperative adhesions,and STHB formulations presented superior e cacy compared to a commercially available adhesion barrier.Histological and immunohistochemical examination showed reduced adhesion formation and minimal immune infiltration in STHB formulations.Our technology demonstrated increased e cacy,ease of use in complex anatomies,and compatibility with di erent delivery methods,providing a robust universal platform to prevent postoperative adhesions in a wide range of surgical interventions. | Guillermo U.Ruiz-Esparza Xichi Wang Xingcai Zhang Sofia Jimenez-Vazquez Liliana Diaz-Gomez Anne-Marie Lavoie Samson Afewerki Andres AFuentes-Baldemar Roberto Parra-Saldivar Nan Jiang Nasim Annabi Bahram Saleh Ali K.Yetisen Amir Sheikhi Thomas H.Jozefiak Su Ryon Shin Nianguo Dong Ali Khademhosseini | 2021 | Nano-Micro Letters2021，13，12： | 2 |
| 2 | Prolonged measles virus shedding in human immunodeficiency virus- infected children,detected by reverse transcriptase -polymerase chain reaction 显示文摘 | Permar SR Moss W J Ryon JJ | 2001 | J Infected Dia2001，183，： | 1 |
| 3 | Chemical flowsheet conditions for preparing urania spheres by internal gelation显示文摘 | HAAS P A BEGOVICH J M RYON A D | 1980 | Ind Eng Chem Prod Res Dev1980，19，3： | 1 |
| 4 | Prolonged measles virus shedding in human immunodeficiency virus - infected children, de- tected by reverse transcriptase - polymerase chain reaction 显示文摘 | Permar SR Moss WJ Ryon JJ | 2001 | J In- fect Dis2001，183，4： | 1 |
| 5 | Uterocalin:a mouse acute phase protein is expressed in the uterus around birth显示文摘 | Liu Q Ryon J Niisen-Hamilton M | 1997 | Mol Reprod Develop1997，46，： | 1 |
| 6 | Scale-up of mixersettlers显示文摘 | Ryon A D Daley F L Lowrie B S | 1959 | Chem Eng Progr1959，55，10： | 1 |
| 7 | An echocardiographic index for sep- aration of right ventricular volume and pressure overload显示文摘 | Ryon T Petrovie O Dillon JC | 1985 | JAmColl Car- diol1985，54，： | 1 |
| 8 | Tissue involution and the acute phase response显示文摘 | Nilsen-Hamilton M Liu Q Ryon J | 2003 | Ann N Y Acad Sci2003，995，1： | 1 |
| 9 | Increased thymic output during acute measles virus infection 显示文摘 | Permar SR Moss WJ Ryon JJ | 2003 | J Virology2003，77，14： | 1 |
| 10 | Colorimetric microtitre plate hybridization assay for the detection of Mycobacterium leproe 16S rRNA in clinical specimens 显示文摘 | HALLE Y RYON JJ | 2004 | Lepr Rev2004，5，1： | 1 |
| 11 | Reverse transcription-PCR detection of Mycobacterium leprae in clinical specimens显示文摘 | KURABACHEW M WONDIMU A RYON JJ | 1998 | J Clin Microbiol1998，36，5： | 1 |
| 12 | Prolonged measles virus shedding in human immunodeficiency virus - infected children, detected by reverse transcriptase -polymcrase chain reaction 显示文摘 | Permar SR Moss WJ Ryon JJ | 2001 | J Infect Dis2001，183，： | 1 |
| 13 | The transistor and energy-dispersive x-ray spectrometry: roots and milestones in x-ray analysis 显示文摘 | RYON W R | 2001 | X-ray spectrometry2001，30，6： | 1 |
| 14 | Clinical study of repig-mentation patterns with either narrow-band ultraviolet B(NBUVB)or 308 nm excimer laser treatment in Koreanvitiligo patients 显示文摘 | Yang YS Cho HR Ryon JH | 2010 | Int J Dermatol2010，49，3： | 1 |
| 15 | Colorimetric microtitre plate hybridization assay for the detection of Mycobacterium leprae 16S rRNA in clinical specimens显示文摘 | Haile Y Ryon JJ | | 0，，01： | 1 |
| 16 | Oxidation sress and antioxidant' therapy: their impact in diabetes-associated erectile dysfunction 显示文摘 | Ling De Young Darryl Yu Ryon m Bateman | 2004 | J Andrology2004，25，5： | 1 |
| 17 | Water, Air, and Soil Pollution 显示文摘 | Michael G Ryon Arthur J Stewart Lynn A Kszos | 2002 | 136(1/2/3/4): 255-2682002，136，1234： | 1 |
| 18 | A comparative study of the im- portance of service quality, dissatisfaction and re- purchase intention in Foodservices of Korean and Japanese显示文摘 | Doo Ryon You | 2011 | Modern Japanese Studies2011，33，3： | 1 |
| 19 | Relational Embeddedness and Learning :The Case of Bank Loan Managers and Their Clients显示文摘 | BRIAN UZZI RYON LANCASTER | 2003 | Management Science2003，49，4： | 1 |
| 20 | Reverse transcription-PCR detection of Mycobacterium leprae in clinical specimens显示文摘 | Kurabachew M Wondimu A Ryon JJ | | 0，，05： | 1 |
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