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| 1 | 软骨母细胞瘤:射频消融术在部分病例中替代外科手术切除显示文摘目的证明射频(RF)消融可以安全有效地治疗有选择的软骨母细胞瘤(selected cases of chondroblastoma)。方法本研究得到机构伦理委员会批准,并符合HIPPA的要求。由于为回顾性研究,故未签署知情同意书。回顾性分析了1995年7月-2007年7月2个医学中心行射频消融治疗后经活检证实为软骨母细胞瘤的病例。在CT引导下进行单极RF消融,同时获得病变影像学资料。记录术前和术后1d症状。由病历记录获取长期随访情况。结果13例男性和4例女性经RF治疗(平均年龄17-3岁)。 | L.D. Rybak D.I. Rosenthal J.C. Wittig 屈瑾(译) 雷新玮(校) | 2009 | 国际医学放射学杂志2009，32，4： | 8 |
| 2 | Intestinal epithelium, intraepithelial lymphocytes and the gut microbiota-Key players in the pathogenesis of celiac disease显示文摘Celiac disease(CD) is a chronic immune-mediated disorder triggered by the ingestion of gluten in genetically predisposed individuals. Before activating the immune system, gluten peptides are transferred by the epithelial barrier to the mucosal lamina propria, where they are deamidated by intestinal tissue transglutaminase 2. As a result, they strongly bind to human leucocyte antigens(HLAs), especially HLA-DQ2 and HLA-DQ8, expressed on antigen-presenting cells. This induces an inflammatory response, which results in small bowel enteropathy. Although gluten is the main external trigger activating both innate and adaptive(specific) immunity, its presence in the intestinal lumen does not fully explain CD pathogenesis. It has been hypothesized that an early disruption of the gut barrier in genetically susceptible individuals, which would result in an increased intestinal permeability, could precede the onset of gluten-induced immune events. The intestinal barrier is a complex functional structure, whose functioning is dependent on intestinal microbiotahomeostasis, epithelial layer integrity, and the gutassociated lymphoid tissue with its intraepithelial lymphocytes(IELs). The aim of this paper was to review the current literature and summarize the role of the gut microbiota, epithelial cells and their intercellular junctions, and IELs in CD development. | Bozena Cukrowska Agnieszka Sowińska Joanna Beata Bierla Elzbieta Czarnowska Anna Rybak Urszula Grzybowska-Chlebowczyk | 2017 | World Journal of Gastroenterology2017，23，42： | 7 |
| 3 | Partial Protection by Lipoic Acid Against Carboplantin-induced Ototoxicity in Rats显示文摘Objective To investigate the alterations in auditory brainstem evoked responses (ABRs) and the changes of carboplatin-induced ototoxicity in the cochlear oxidant/antioxidant systems and otoprotection by an antioxidant lipoate. Methods Male wistar rats were divided into four groups and treated as follows: 1) vehicle (saline) control, 2) carboplatin (256 mg/kg, i.p.), 3) lipoate (100 mg/kg, i.p.), 4) lipoate + carboplatin. Post-treatment ABRs were performed after four days and rats were sacrificed with their cochleae harvested and analyzed. Results Carboplatin significantly elevated ABR threshold above the pretreatment thresholds. Lipoate+carboplatin treated rats showed decreased elevation of hearing threshold. Carboplatin significantly depleted cochlear reduced to oxizized glutathione (GSH/GSSG) ratio, whereas lipoate+carboplatin treatment increased GSH/GSSG ratio. Carboplatin significantly decreased cochlear copper zinc-superoxide dismutase (CuZn-SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and glutathione-S-transferase (GST) activities and enzyme protein expressions and a significant increase in Mn-SOD activity, protein expression and malondialdehyde (MDA) level. Cochlear antioxidant enzyme activities, enzyme protein expressions and MDA level were partially restored in lipoate+carboplatin treated rats, compared to carboplatin alone. Conclusion Carboplatin-induced ototoxicity is related to impairment of cochlear antioxidant system and otoprotection conferred by lipoate is associated with partial sparing of the cochlear antioxidant defense system. | KAZIM HUSAIN CRAIG WHITWORTH SATU M. SOMANI LEONARD P. RYBAK | 2005 | Biomedical and Environmental Sciences2005，18，3： | 3 |
| 4 | 用体外心内膜赘生物模型评价万古霉素和达托霉素对甲氧西林耐药金葡菌和异质性万古霉素中介金葡菌的抗菌活性显示文摘 | Leonard SN Rybak MJ 袁瑾懿 王明贵 | 2010 | 中国感染与化疗杂志2010，10，3： | 2 |
| 5 | Mechanism of cisplatin ototoxicity:antioxidant system显示文摘 | Ravi R Somani SM Rybak LP | 1995 | Pharmacol Toxicol1995，76，6： | 1 |
| 6 | Vancomy- cin therapeutic guidelines显示文摘 | Rybak MJ Lomaestro BM Rotscahfer JC | 2009 | Clin Infect Dis2009，49，3： | 1 |
| 7 | A feedback loop comprising lin-28 and let-7 controls pre-let-7maturation during neural stem-cell commitment 显示文摘 | Rybak A Fuchs H Smirnova L Brandt C Pohl EE Nitsch R etal | 2008 | Nat CellBioi2008，10，8： | 1 |
| 8 | Pharmacodynamics : relation to antimicrobial re- sistance显示文摘 | Rybak MJ | 2006 | Am JMed2006，119，1： | 1 |
| 9 | The pharmacokinetic and pharmacodynamic proper- ties of vaneomyein显示文摘 | Rybak MJ | 2006 | Clin Infect Dis2006，42，1： | 1 |
| 10 | Epidemiology, resistance, and outcomes of Acinetobacter baumannii bacteremia treated with imipenem - cilastatin or ampieillin - sulbactam 显示文摘 | Jellison T K Mckinnon P S Rybak M J | 2001 | Pharmacotherapy2001，21，2： | 1 |
| 11 | Pharmacodynamics: relalion to anlimicrobial resistance显示文摘 | Rybak MJ | 2006 | Am J Infect Control2006，1，： | 1 |
| 12 | Mechanism of protection by diethyldithiocarbamate against cisplatin ototoxicity:Antioxidant system 显示文摘 | Rybak LP Ravi R Somani SM | 1995 | Fundam Appl Toxicol1995，26，2： | 1 |
| 13 | Bactericidal activities of two daptomycin regimens against clinical strains of glycopeptide intermediate-resistant Staphylococcus aureus,vancomycin-resistant Enterococcus faecium,and methicillin-resistant Staphylococcus aureus isolates in an in vitro phar显示文摘 | Akins R L Rybak M J | | 0，，： | 1 |
| 14 | Vitamin E reduces cisplatin ototoxicity显示文摘 | Kalkanis JG Whitworth C Rybak LP | 2004 | Laryngoscope2004，114，： | 1 |
| 15 | Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells显示文摘 | He L Ingram A Rybak AP | 2010 | J Clin Invest2010，120，6： | 1 |
| 16 | Impact of dose de-escala- tion and escalation on daptomycin spharmacodynamics against clinical methicillirr resistant Staphylococcus aureus isolates in an in vitro model 显示文摘 | Vidaillac C Steed ME Rybak MJ | 2011 | Antimicrob Agents Chemother2011，1455，5： | 1 |
| 17 | Radiological imaging for the diagnosis of bone metastases显示文摘 | Rybak LD Rosenthal DI | 2001 | Q J Nucl Med2001，45，1： | 1 |
| 18 | Mechanism of cisplatin ototoxicity : antioxidant system 显示文摘 | Ravi R Somani SM Rybak LP | 1995 | Pharmacol Toxicol1995，76，： | 1 |
| 19 | Applicability of the transport equa- tion in the one-dimensional wave-propagation problem 显示文摘 | Belov V D Rybak S A | 1975 | Journal of Soviet Physics Acoustics1975，21，2： | 1 |
| 20 | Nephrotoxicity of vancomycin,alone and with an aminoglucoside显示文摘 | Rybak MJ Albrecht LM Boike SC | 1990 | Antimicrob Chemother1990，25，4： | 1 |
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