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| 1 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | Partial characterization of a hepatocyte growth factor from rat platelets显示文摘 | Russell WE Mc Gowan JA Bucher NLR | 1984 | J Cell Physiol1984，119，： | 1 |
| 3 | A novel risk-adjusted nomogram for rectal cancer surgery outcomes显示文摘 | RUSSELL MC YOU YN HU CY | 2013 | JAMA Surg2013，148，8： | 1 |
| 4 | Biological activity and enrichment of spermatogonial stem cells in vitamin A-deficient and hyperthermia-exposed testes from mice based on colonization following germ cell transplantation显示文摘 | Mc Lean D J Russell L D Griswold M D | 2002 | Biol Reprod2002，66，： | 1 |
| 5 | LFA-1 -specifictherapy prolongs allograft survival in rhesus macaques 显示文摘 | Badell IR Russell MC Thompson PW | 2010 | J ClinInvest2010，120，12： | 1 |
| 6 | Scientific resistance to research, training and utilization of eye movement desensitization and reprocessing (EMDR) therapy in treating post-war disorders显示文摘 | Russell MC | 2008 | Soc Sci Med2008，67，11： | 1 |
| 7 | Phase 2 study of an HIV-1 canarypox vaccine (vCPI452) alone and in combination with rgpl20: negative results fail to trigger a phase 3 correlates trial 显示文摘 | Russell ND Graham BS Keefer MC | 2007 | J Acquir Immune Defic Syndr2007，44，2： | 1 |
| 8 | The relationship among family domain variables and work - family conflict for men and women 显示文摘 | Loerch KJ Russell JEA Rush MC | 1989 | J Vocat Behav1989，35，3： | 1 |
| 9 | Paving the way:stepping stones to evidence-based nursing显示文摘 | Wallace MC Shorten A Russell KG | 1997 | Int J Nursing Practice1997，3，3： | 1 |
| 10 | Surgical approaches to gastric cancer显示文摘 | Russell MC Mansfield PF | 2013 | J Surg Oncol2013，107，3： | 1 |
| 11 | Stable inhibition of hepatitis B virus proteins by small interfering RNA expressed from viral vectors显示文摘 | Moore M D Mc Garvey M J Russell R A | 2005 | J Gene Med2005，7，7： | 1 |
| 12 | Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms 显示文摘 | Maiden MC Bygraves JA Fell E MoreUi G Russell JE Urwin R Zhang Q Zhou J Zurth K Caugant DA Feavers IM Achtman M Spratt BG | 1998 | Proe Natl Acad gel USA1998，95，6： | 1 |
| 13 | Magnetic lattices for ultracold atoms and degenerate quantum gases显示文摘We review recent developments in the use of magnetic lattices as a complementary tool to optical lattices for trapping periodic arrays of ultracold atoms and degenerate quantum gases. Recent advances include the realisation of Bose–Einstein condensation in multiple sites of a magnetic lattice of one-dimensional microtraps, the trapping of ultracold atoms in square and triangular magnetic lattices,and the fabrication of magnetic lattice structures with submicron period suitable for quantum tunnelling experiments.Finally, we describe a proposal to utilise long-range interacting Rydberg atoms in a large spacing magnetic lattice to create interactions between atoms on neighbouring sites. | Yibo Wang Prince Surendran Smitha Jose Tien Tran Ivan Herrera Shannon Whitlock Russell Mc Lean Andrei Sidorov Peter Hannaford | 2016 | Science Bulletin2016，61，14： | 1 |
| 14 | LFA-l-specific therapy prolongs allograft survival in rhesus macaques显示文摘 | Badell IR Russell MC Thompson PW | 2010 | J Clin Invest2010，120，12： | 1 |
| 15 | Phase 2 study of an HIV-1 canarypox vaccine (vCP1452) alone and in combination with rgp120: negative results fail to trigger a phase 3 correlates trial显示文摘 | Russell ND Graham BS Keefer MC | 2007 | J Acquir Immune Defic Syndr2007，44，2： | 1 |
| 16 | Laparoscopic and minilaparotomy Cholecys ctomy: a randomized trial comparing postoperative pain and pulmonary function 显示文摘 | Mc Mahon A J Russell IT Ramsary G | 1994 | Surgery1994，115，5： | 1 |
| 17 | Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation显示文摘 | Friedmann MC Migone TS Russell SM | 1996 | Proc Natl Acad Sci USA1996，93，5： | 1 |
| 18 | Recommendations for reporting cost-effectiveness analysis显示文摘 | Siegel JE Weinstein MC Russell LB | 1996 | JAMA1996，276，16： | 1 |
| 19 | Fractal growth modelling of I2O5 nanoparticles显示文摘 | Russell W Saunders John Mc Plane | 2006 | Aerosol Science2006，37，： | 1 |
| 20 | Sulfated glycosarninoglycans and glucosaminemay synergize in promotings Synovial hyaluronic acid synthesis 显示文摘 | Mc Carty MF Russell AL Seed NIP | 2000 | Med Hypotheses2000，54，5： | 1 |
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