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| 1 | Current application of proteomics in biomarker discoveryfor inflammatory bowel disease显示文摘Recently, the field of proteomics has rapidly expanded in its application towards clinical research with objectives ranging from elucidating disease pathogenesis to discovering clinical biomarkers. As proteins govern and/or reflect underlying cellular processes, the study of proteomics provides an attractive avenue for research as it allows for the rapid identification of protein profiles in a biological sample. Inflammatory bowel disease(IBD) encompasses several heterogeneous and chronic conditions of the gastrointestinal tract. Proteomic technology provides a powerful means of addressing major challenges in IBD today, especially for identifying biomarkers to improve its diagnosis and management. This review will examine the current state of IBD proteomics research and its use in biomarker research. Furthermore, we also discuss the challenges of translating proteomic research into clinically relevant tools. The potential application of this growing field is enormous and is likely to provide significant insights towards improving our future understanding and management of IBD. | Patrick PY Chan Valerie C Wasinger Rupert W Leong | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 5 |
| 2 | Evaluation of the string test for the detection of Helicobacter pylori显示文摘AIM: Helicobacter pylori can be diagnosed by invasive ornon-invasive tests but to obtain bacteria for culture andantibiotic susceptibility testing, an upper GI endoscopy isoften required. The string test may be a minimally-invasivealternative method of obtaining H. pylori samples. This studyevaluates the sensitivity and specificity of the string test inthe diagnosis of H. pylori in comparison with endoscopicmeans of diagnosis.METHODS: This was a prospective open comparative studyof patients with dyspepsia with endoscopy-based tests asgold standard (defined as a positive CLO test and antralhistology). Fasting patients swallowed the encapsulated-string(Entero-test Hp), which was withdrawn after 1 hour. Thegastric juice from the string was plated onto H. pylori-selectivemedia for culture. Helicobacter pylori was identified by typicalcolony morphology, gram stain and biochemical test results.RESULTS: Thirty dyspeptic patients were recruited of whom21 (70 %) were positive for H. pylori according to the goldstandard. The sensitivity, specificity, positive predictive value,and negative predictive value for the string test were 38 %,100 %, 100 % and 41% respectively, and for endoscopicbiopsies 81%, 100 %, 100 %, 69 % respectively (P=0.004).Logistic regression showed that only abundant growthdensity from endoscopic biopsy cultures to be a predictor ofa positive string test (P=0.018).CONCLUSION: The string test is an alternative method toendoscopy in obtaining H. pylori but has a low sensitivitycompared to endoscopic biopsies. | Rupert WL Leong Ching C Lee Thomas KW Ling WaiK Leung Joseph JY Sung | 2003 | World Journal of Gastroenterology2003，9，2： | 3 |
| 3 | Figured grain in aspen is heritable and not affected by graft-transmissible signals显示文摘 | FAN Y RUPERT K WIEDENHOEFT A C | 2013 | Trees2013，27，4： | 1 |
| 4 | Hectare-scale demonstration of high rate algal pinds for enhanced wastewater treatment and biofuel production显示文摘 | RUPERT C DONNA S HELENA C | | 0，，03： | 1 |
| 5 | Cloning of the phr gene and amplification of photolyase in Escherichia coli显示文摘 | Sancar A Rupert C S | 1978 | Gene1978，4，4： | 1 |
| 6 | 6-A- mino-2- ( 4-fluomphenyl ) -4-methoxy-3-( 4-pyridyl ) -1H-pyrrolo pyridine ( RWJ 68354) : a potent and selective p38 kinase inhibitor显示文摘 | HENRY J R RUPERT K C DODD J H | | J Med Chem0，41，22： | 1 |
| 7 | A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome 显示文摘 | Brown C J Ballabio A Rupert J L | 1991 | Nature1991，349，6304： | 1 |
| 8 | Spatial and historical variation in sediment phosphorus fractions and mobility in a large shallow lake显示文摘 | BRYAN M S LAURENCE C RUPERT P | 2006 | Water Research2006，40，： | 1 |
| 9 | Triple-negative breast cancer显示文摘 | Rupert Bartsch Reinhard Ziebermayr Christoph C | 2010 | Wien Med Wochenschr2010，160，78： | 1 |
| 10 | Spatial and historical variation in sediment phosphorus fractions and mobility in a large shallow lake 显示文摘 | BRYAN M S LAURENCE C RUPERT P | 2006 | Water Research2006，4，4： | 1 |
| 11 | A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome显示文摘 | Brown C J Ballabio A Rupert JL | 1991 | Nature1991，349，： | 1 |
| 12 | Tax Policy and Planning Implications of Hidden Taxes:Effective Marginal Tax Rate Exercises 显示文摘 | Fischer C M Rupert T J Wartick M L | 2001 | Journal of Accounting Education2001，19，1： | 1 |
| 13 | Texture analysis in non-contrast enhanced CT: Impact of malignancy on texture in apparently disease-free areas of the liver显示文摘 | Balaji Ganeshan Kenneth A Miles Rupert C D Young | 2009 | Eur J Radiol2009，70，： | 1 |
| 14 | Adapta- tion and conservation of physiological systems in the evo- lution of human hypoxia tolerance 显示文摘 | HOCHACHKA P W RUPERT J I MONGE C | 1999 | Comparative Bio- chemistl7 and Physiology Part A : Molecular & Integrative Physiology1999，124，1： | 1 |
| 15 | Adapta- tion and conservation of physiological systems in the evo- lution of human hypoxia tolerance 显示文摘 | HOCHACHKA PW RUPERT JL MONGE C | 1999 | Comparative Bio- chemistry and Physiology Part A: Molecular & Integrative Physiology1999，，1： | 1 |
| 16 | Spatial and historical variation in sediment phosphorusfractions and mobility in a large shallow lake显示文摘 | Bryan M S Laurence C Rupert P | 2006 | Water Research2006，40，： | 1 |
| 17 | Adaptation and conserveation of physiologyical systems in the evolution of human hypoxia tolerance显示文摘 | Hochachka P W Rupert J L Monge C | 1999 | Comp Biochem Physiol Part A1999，124，： | 1 |
| 18 | Peach fruit ripening and quality in relation to picking time and hypoxic and high CO2 shortterm postharvest treatments显示文摘 | BONGHI C RAMINA A RUPERT B | 1999 | Postharvest Biology and Technology1999，，： | 1 |
| 19 | Performance comparison of a linear parametric noise estimation wiener filter and non - linear joint transform correlator for realistic clutter backgrounds显示文摘 | Sovira Tan Rupert C D Young | 2000 | Opt com- mun2000，182，1： | 1 |
| 20 | Proteomics and metabolomics in inflammatory bowel disease显示文摘 | Yunki Yau Rupert W Leong Ming Zeng Valerie C Wasinger | 2013 | J Gastroenterol Hepatol2013，，7： | 1 |
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