| 1 | A rare case of visceral leishmaniasis misdiagnosed as systemic lupus erythematosus显示文摘Visceral leishmaniasis(VL)is an infectious disease caused by Leishmania donovani and transmitted by sandflies.It can be life-threatening if not treated.Common clinical features of VL include recurrent fever,pancytopenia,splenomegaly,and a variety of positive autoantibodies,which can lead to a misdiagnosis of systemic lupus erythematosus(SLE).We report the case of a 25-year-old woman with VL misdiagnosed as SLE to add to the existing literature on this subject. | Mai Zheng Shuang Liu Xiangyu Wang XingJun Li Nan Wang Yulong Guo Jingyi Yang Bibhuti Upreti Ruomei Cui Jian Xu | 2021 | Rheumatology & Autoimmunity2021，1，1： | 0 |
| 2 | Association between HLA-B and HLA-DRB1 polymorphisms and systemic lupus erythematosus in Han population in China显示文摘We explored the association between HLA-B and HLA-DRB1 polymorphisms and reviewed clinical characteristics of systemic lupus erythematosus(SLE)in Han population in Yunnan,China.Methods:There were 295 patients and 265 healthy control subjects(HCs)enrolled in the study.Clinical data and blood samples were collected from the patients.The HLA-B and HLA-DRB1 genotypes were detected in SLE patients and HCs.Results:A total of 74 genotypes on HLA-B loci were determined in 288 patients as well as 57 genotypes in 265 HCs.The results showed SLE was associated with the HLA-B*40:01 and HLA-DRB1*08:03 alleles,and the HLAB*46:01,HLA-DRB1*12:02,DRB1*04:03,DRB1*14:01,DRB1*04:06,and DRB1*11:01 alleles were less likely to appear in SLE patients.Additionally,HLA-B*07:02 and B*40:06 were associated with disease activity.HLADRB1*03:01,DRB1*13:02,and DRB1*12:01 were associated with proteinuria.Furthermore,HLA-B*51:01,B*13:02,B*38:02,B*35:01,HLA-DRB1*15:02,DRB1*15:04,DRB1*15:01,and DRB1*08:03 were correlated with inflammatory factors and immune dysfunction.HLA-B*15:25 was related to the production of multiple antibodies.HLA-DRB1*12:02 might be a protective factor for pancytopenia.The haplotype of HLA-B*40:01/DRB1*08:03 was linked with SLE.Conclusion:SLE in Han population in Yunnan province was associated with the HLA-B*40:01 and HLA-DRB1*08:03 alleles,and the haplotype HLAB*40:01/DRB1*08:03.Several alleles were associated with inflammation,immune disorders,and organ involvement in SLE.Those alleles might be potential genetic markers of SLE. | Xiangyu Wang Yifan Yang Bibhuti Upreti Shuang Liu Ruomei Cui Yuqi Cheng Li Tao Jing Dong Luqiong Li Jian Xu | 2022 | Rheumatology & Autoimmunity2022，2，1： | 0 |
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