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| 1 | Sustained release of hydrogen sulfide from anisotropic ferrofluid hydrogel for the repair of spinal cord injury显示文摘Spinal cord injury(SCI)results in massive neuronal death,axonal disruption,and cascading inflammatory response,which causes further damage to impaired neurons.The survived neurons with damaged function fail to form effective neuronal circuits.It is mainly caused by the neuroinflammatory microenvironment at injury sites and regenerated axons without guidance.To address this challenge,a ferrofluid hydrogel(FFH)was prepared with Ferric tetrasulfide(Fe3S4),carboxymethyl chitosan,and gold.Its internal structural particles can be oriented in a magnetic field to acquire anisotropy.Moreover,Fe3S4 can release hydrogen sulfide(H2S)with anti-inflammatory effects under acidic conditions.Regarding in vitro experiments,0.01g/ml Fe3S4 FFH significantly reduced the inflammatory factors produced by LPS-induced BV2 cells.Oriented and longer axons of the induced neural stem cells loaded on anisotropic FFH were observed.In vivo experiments showed that FFH reduced the activated microglia/macrophage and the expression of pro-inflammatory factors in SCI rats through the NF-κB pathway.Moreover,it significantly promoted directional axonal regrowth and functional recovery after SCI.Given the critical role of inhibition of neuroinflammation and directional axonal growth,anisotropic Fe3S4 FFH is a promising alternative for the treatment of SCI. | Ruofei Wang Xia-Xiao Wu Zhenming Tian Tian Hu Chaoyang Cai Guan-Ping Wu Gang-Biao Jiang Bin Liu | 2023 | Bioactive Materials2023，，5： | 1 |
| 2 | SelV assemloiy fabrieation of 3D fower-ike ZnO laierareb, iea1, nanostructures and their gas sensing properties 显示文摘 | Zhang Haijiao Wu Ruofei Chen Zhiwen | 2012 | Crystal Engineering2012，14，： | 1 |
| 3 | Chemical composition and formation mechanisms in the cathode-electrolyte interface layer of lithium manganese oxide batteries from reactive force field (ReaxFF) based molecular dynamics显示文摘 | Sahithya REDDIVARI Christian LASTOSKIE Ruofei WU Junliang ZHANG | 2017 | Frontiers in Energy2017，11，3： | 0 |
| 4 | Facile controlled synthesis of hierarchically structured mesoporous Li_(4)Ti_(5)O_(12)/C/rGO composites as high-performance anode of lithium-ion batteries显示文摘t In this paper,a facile strategy is proposed to controllably synthesize mesoporous Li_(4)Ti_(5)O_(12)/C nanocomposite embedded in graphene matrix as lithium-ion battery anode via the co-assembly of Li_(4)Ti_(5)O_(12)(LTO)precursor,GO,and phenolic resin.The obtained composites,which consists of a LTO core,a phenolic-resin-based carbon shell,and a porous frame constructed by rGO,can be denoted as LTO/C/rGO and presents a hierarchical structure.Owing to the advantages of the hierarchical structure,including a high surface area and a high electric conductivity,the mesoporous LTO/C/rGO composite exhibits a greatly improved rate capability as the anode material in contrast to the conventional LTO electrode. | Cehuang FU Shuiyun SHEN Ruofei WU Xiaohui YAN Guofeng XIA Junliang ZHANG | 2022 | Frontiers in Energy2022，16，4： | 0 |
| 5 | DNMT3A reads and connects histone H3K36me2 to DNA methylation显示文摘Dear Editor,DNA methylation at the 5-position of cytosine(5mC)is a crucial epigenetic mark in regulating biological processes including gene silencing,gene imprinting,and X chromo-some inactivation(Jaenisch and Bird,2003;Smith and Meissner,2013).Human genome encodes three DNA methyltransferases,DNMT1,DNMT3A and DNMT3B to catalyze 5mC.Although not tightly restricted,DNMT1 is thought to maintain the established pattern of 5mC throughout DNA replication,while DNMT3A and DNMT3B are largely responsible for the de novo establishment of 5mC.It has long been questioned how de novo DNA 5mC patterns are established in different genomic regions and whether histone modifications crosstalk to the process.Until recently,it was reported that through recognition of histone H3K36me3 mark,DNMT3B plays a dominant role in medi-ating DNA 5mC in the genic region undergoing active tran-scription(Baubec et al.,2015;Neri et al,2017).However,5mC occurs at both intergenic and genic regions,while H3K36me3 is largely absent in the intergenic regions,indi-cating that the intergenic 5mC may be mediated through diferent mechanisms. | Wenqi Xu Jiahui Li Bowen Rong Bin Zhao Mei Wang Ruofei Dai Qilong Chen Hang Liu Zhongkai Gu Shuxian Liu Rui Guo Hongjie Shen Feizhen Wu Fei Lan | 2020 | Protein & Cell2020，11，2： | 0 |
| 6 | Correction to:DNMT3A reads and connects histone H3K36me2 to DNA methylation显示文摘The author would like to add the below information in this correction.A similar study from Chao Lu group was published online on 5 September 2019 in Nature,entitled“The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape”(Weinberg et al.,2019).Although both studies reported the preferential recognition of H3K36me2 by DNMT3A PWWP,ours in addition uncovered a stimulation function by such interaction on the activity of DNMT3A.On the disease connections,we used a NSD2 gain-of-function model which led to the discovery of potential therapeutic implication of DNA inhibitors in the related cancers,while the other study only used NSD1 and DNMT3A loss-of-function models. | Wenqi Xu Jiahui Li Bowen Rong Bin Zhao Mei Wang Ruofei Dai Qilong Chen Hang Liu Zhongkai Gu Shuxian Liu Rui Guo Hongjie Shen Feizhen Wu Fei Lan | 2020 | Protein & Cell2020，11，3： | 0 |
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