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您的检索式：作者名="Ruobing Guo"
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| 1 | Geological Features and Reservoiring Mode of Shale Gas Reservoirs in Longmaxi Formation of the Jiaoshiba Area显示文摘This study is based on the sedimentation conditions, organic geochemistry, storage spaces, physical properties, lithology and gas content of the shale gas reservoirs in Longmaxi Formation of the Jiaoshiba area and the gas accumulation mode is summarized and then compared with that in northern America. The shale gas reservoirs in the Longmaxi Formation in Jiaoshiba have good geological conditions, great thickness of quality shales, high organic content, high gas content, good physical properties, suitable depth, good preservation conditions and good reservoir types. The quality shales at the bottom of the deep shelf are the main target interval for shale gas exploration and development. Shale gas in the Longmaxi Formation has undergone three main reservoiring stages:the early stage of hydrocarbon generation and compaction when shale gas reservoirs were first formed; the middle stage of deep burial and large-scale hydrocarbon generation, which caused the enrichment of reservoirs with shale gas; the late stage of uplift, erosion and fracture development when shale gas reservoirs were finally formed. | GUO Xusheng HU Dongfeng LI Yuping LIU Ruobing WANG Qingbo | 2014 | Acta Geologica Sinica(English Edition)2014，88，6： | 28 |
| 2 | Sphingosine-1-phosphate,a novel TREM2 ligand,promotes microglial phagocytosis to protect against ischemic brain injury显示文摘The mechanism of sphingosine-1-phosphate(S1P)-mediated phagocytosis remains unknown.Here,we found that S1P or FTY720(an analog of S1P)promoted microglial phagocytosis in stroke independent of S1PRs.First,we used computer simulation of molecular docking to predict that S1P might be a ligand for triggering receptor expressed on myeloid cells 2(TREM2).Next,microscale thermophoresis(MST),surface plasmon resonance(SPR)and liquid chromatography–tandem mass spectrometry(LC–MS/MS)were performed to reveal that S1P was a novel TREM2 ligand.Then,we confirmed the pro-phagocytosis of S1P targeting in Trem2-Dap12 transfected CHO cells and TREM2 knockdown microglia.Point mutation analysis showed that D104 was the critical binding residue.Trem2^(−/−)mice were used to demonstrate the role of S1P-induced phagocytosis targeting on TREM2 in protecting against ischemic brain injury.Finally,further studies revealed that apolipoprotein E(APOE)loaded with S1P was released by microglia and bound to apoptotic neurons via LDL receptor related protein 1B(LRP1B)and thereby induced microglia to phagocytose apoptotic neurons.Overall,the present work reveals for the first time that S1P acts as a novel endogenous ligand of TREM2 to effectively promote microglial phagocytosis.Our findings provide a new lead compound for developing immunomodulator targeting on TREM2. | Tengfei Xue Juan Ji Yuqin Sun Xinxin Huang Zhenyu Cai Jin Yang Wei Guo Ruobing Guo Hong Cheng Xiulan Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 3 |
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