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1Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum显示文摘典型药用的植物的主要成分,蓼 multiflorum (用汉语的 Heshouwu ) ,那导致特质的肝损害仍然保持不清楚。我们的以前的工作证明了有 lipopolysaccharide (LPS ) 的无毒的剂量和 Heshouwu 的治疗学的剂量的 cotreatment 能在老鼠导致肝损害,而独唱治疗不能导致看得见的损害。在现在的工作,用成分大美人和敲门在里面策略,我们发现 Heshouwu 的乙醇醋酸盐(EA ) 摘录在对待 LPS 的老鼠显示了可比较的特质的 hepatotoxicity 到整个摘录。结果显示血浆丙氨酸 aminotransferase, aspartate aminotransferase,和肝 histologic 的重要举起变化,而另外的分开的部分没能导致肝损害。有另外的分开的部分的 EA 摘录的混合在对待 LPS 的老鼠导致了可比较的特质的 hepatotoxicity 到整个摘录。化学分析进一步揭示了那 2,3,5,4-tetrahydroxy trans-stilbene-2-O -- 配糖物(trans-SG ) 和它的 cis 异构体是在 EA 的二主要混合物摘录。而且,孤立的 cis- ,并且不它的 trans 异构体,显示的可比较的特质的 hepatotoxicity 到在对待 LPS 的老鼠的 EA 摘录。cis-SG 的更高的内容从与收集的将军相比与 Heshouwu 联系的实际的肝沉醉病人在 Heshouwu 白酒或准备被检测样品。另外,血浆 metabolomics 分析证明 cis-SG-disturbing 充实显著地不同于的小径在对待 LPS 的老鼠的 trans-SG。所有这些结果建议 cis-SG 仔细与 Heshouwu 的特质的 hepatotoxicity 被联系。认为 trans-SG 的 cis-trans 异构化被紫外光或日光调停,我们的调查结果为在药发现控制 photoisomerization 并且为 Heshouwu 和芪相关的药的临床的使用用作参考。Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang 2017Frontiers of Medicine2017,11,2:41
2Review on the Technological Development and Application of UAV Systems显示文摘Unmanned aerial vehicles(UAVs) are products of deep integration of aviation technology and Information technology(IT). The core factor of why the UAV industry can become a relatively independent industry and experience rapid development is the full penetration of IT into the aviation industry. Under the networked environment, UAVs are now becoming datadriven mobile agents. With the development of information technology, information transmission networking, operation space digitizing, and flight platform intelligentizing will become the main trends of technological development of UAV systems. The application of UAV systems is not merely a paradigm in transportation, but will more importantly produce 'UAV+' novel production modes,service formats, and combat modes associated with UAVs.These emerging trends will have profound impacts on future economic and social development as well as the building of armed forces.FAN Bangkui LI Yun ZHANG Ruiyu FU Qiqi 2020Chinese Journal of Electronics2020,29,2:26
3Thoughts on the Implementation Path to a Carbon Peak and Carbon Neutrality in China’s Steel Industry显示文摘1.The CO_(2) emission status of the steel industry in China As an important basic sector of the national economy,China’s steel industry is a major energy consumer and a major emitter of carbon dioxide(CO_(2)).Based on previous studies[1-3],Fig.1 shows a preliminary estimation of the CO_(2) emissions of the steel industry in China from 1991 to 2019.Ruiyu Yin Zhengdong Liu Fangqin Shangguan 2021Engineering2021,7,12:15
4阿柏西普玻璃体腔注射和光动力疗法治疗中国新生血管性老年性黄斑变性患者的疗效对比:SIGHT研究显示文摘目的对比观察玻璃体注射阿柏西普(IAI)和光动力疗法(PDT)治疗中国继发于新生血管性老年性黄斑变性(nAMD)的经典为主型脉络膜新生血管(CNV)患者的安全性和有效性。方法随机、双盲、多中心为期52周(2011年12月至2014年8月)的Ⅲ期临床研究。研究注册码NCT01482910。入组患者按照3:1比例随机分为IAI组、PDT→IAI组。IAI组患者在基线和第4、8、16、24、32、40、48周时接受2 mg IAI治疗,第28、36周时分别接受假注射治疗。PDT→IAI组患者在基线时均强制接受1次PDT治疗,第12、24周时若满足PDT再治疗条件,则再次予以PDT治疗;基线和第4、8、16、24周时接受假注射治疗,第28、32、36、40、48周时接受2 mg IAI治疗。报告的主要有效性结果为第28周时平均BCVA相较基线的变化和第52周时的结果。安全性评价包括发生治疗相关不良事件(TEAEs)患者百分比。结果入组304例患者中,IAI组、PDT→IAI组分别为228、76例。第28周时,IAI组、PDT→IAI组患者平均BCVA较基线变化值分别为+14.0、+3.9个字母;第52周时,两组患者BCVA较基线变化值分别为+15.2、+8.9个字母,差异为+6.2个字母(95% CI 2.6~9.9,P=0.000 9)。第52周时,两组患者平均中心凹视网膜厚度分别下降?189.6、?170.0 μm。IAI组中BCVA提高最为显著者为年龄<65岁、活动性CNV面积<总病灶面积50%者。IAI组、PDT→IAI组患者眼部最常见TEAEs为黄斑纤维化[11.8%(27/228)、6.6%(5/76)]、BCVA下降[6.6%(15/228)、21.1%(16/76)]。抗血小板研究合作组定义的动脉血栓栓塞事件3例,但均被认为与药物无关。结论中国nAMD患者阿柏西普治疗效果优于PDT。阿柏西普疗效在全部患者中均可持续至第52周。不良事件的发生率与已知的阿柏西普安全性数据一致。黎晓新 陈有信 张军军 许迅 张风 ChuiMing Gernmy Cheung RuiYu HusainKazmi OlafSowade OliverZeitz on behalf of the SIGHT study group 2019中华眼底病杂志2019,35,2:9
5Experimental investigation on static/dynamic characteristics of a fast-response pressure sensitive paint显示文摘An optical-based technique using Pressure-Sensitive Paint(PSP) is a promising method to measure the distribution of surface pressure on an aerodynamic model. The static and dynamic characteristics of a fast-response PSP that is developed in the Chinese Academy of Sciences(CAS)are analyzed and tested to serve as the basis for experiments on unsteady surface measurement using a fast-response PSP. Two calibration systems used for this study are set up to investigate the temperature dependency, response time, and resolution. A data processing method, used for dynamic data, is analyzed and selected carefully to determine the optimum signal. Results show that the fastresponse PSP can be used normally at temperatures from 25 ℃ to 80 ℃. The effect of temperature on the accuracy of the measurement must be considered when temperatures are beyond the temperature range of 30–40 ℃. The dynamic calibration device with a solenoid valve can achieve a pressure jump within a millisecond order. The resolution is determined by the signal-to-noise ratio of the photo-multiplier tube. Results of the measurement show that the response time of the PSP decreases with a large pressure variation, and the response time is below 0.016 s when the pressure variation is under 40 kPa.Ruiyu LI Limin GAO Tianlong ZHENG Guanhua YANG 2018Chinese Journal of Aeronautics2018,31,6:8
6Influence of leading edge with real manufacturing error on aerodynamic performance of high subsonic compressor cascades显示文摘To investigate the influence of real leading-edge manufacturing error on aerodynamic performance of high subsonic compressor blades,a family of leading-edge manufacturing error data were obtained from measured compressor cascades.Considering the limited samples,the leadingedge angle and leading-edge radius distribution forms were evaluated by Shapiro-Wilk test and quantile–quantile plot.Their statistical characteristics provided can be introduced to later related researches.The parameterization design method B-spline and Bezier are adopted to create geometry models with manufacturing error based on leading-edge angle and leading-edge radius.The influence of real manufacturing error is quantified and analyzed by self-developed non-intrusive polynomial chaos and Sobol’indices.The mechanism of leading-edge manufacturing error on aerodynamic performance is discussed.The results show that the total pressure loss coefficient is sensitive to the leading-edge manufacturing error compared with the static pressure ratio,especially at high incidence.Specifically,manufacturing error of the leading edge will influence the local flow acceleration and subsequently cause fluctuation of the downstream flow.The aerodynamic performance is sensitive to the manufacturing error of leading-edge radius at the design and negative incidences,while it is sensitive to the manufacturing error of leading-edge angle under the operation conditions with high incidences.Chi MA Limin GAO Haohao WANG Ruiyu LI Baohai WU 2021Chinese Journal of Aeronautics2021,34,6:7
7Synthesis, Characterization and Evaluation of Sulfur Transfer Catalysts for FCC Flue Gas显示文摘In this work, Zr-M(M=Cu, Mn, Ce) type sulfur transfer agent was prepared by impregnation method. Under the condition similar to that in the regenerator of FCC units, the influence of different active metal components and their contents on sulfur transfer agent were investigated. Moreover, the crystalline structure of sulfur transfer agent was characterized by X-ray diffraction(XRD) and Fourier transforms infrared spectroscopy(FT-IR). The result showed that the Zr-Mn sulfur transfer agent could effectively reduce the SO2 content in FCC regenerator flue gas, featuring high SO2 adsorption capacity. The sulfur transfer agent was inactivated in 40—60 min during the test. In the course of reduction reaction, after several reaction cycles, the formation of SO2 ceased and only H2 S was detected as the reduction product.Jiang Ruiyu Shan Honghong Zhang Jiling Yang Chaohe Li Chunyi 2014China Petroleum Processing & Petrochemical Technology2014,16,2:5
8Rice allelopathy and its properties of molecular ecology显示文摘Crop allelopathy is a promising and environmentally friendly method in weed control;however,the inducible genetic trait for allelopathy in the suppression of weeds needs to be overcome for practical use.Further study needs to be directed to this end to elucidate the molecular genetics and its physiologic mechanism.In this paper,the authors review recent advances in the investigation of rice allelopathy and its molecular regulatory mechanism,especially in responses to stressful conditions including biotic and abiotic factors in China.Previous studies show that rice allelopathy could be enhanced when the rice accession was exposed to stressful conditions,and further analysis by the transcriptomics and proteomics approaches conducted in our laboratory indicated that the increase in allelopathic potential of rice,when exposed to the stresses,was attributed to increased expression level of genes involved in phenolic synthetic metabolism.The increasing phenolic compounds have been confirmed as the main allelochemicals and they jointly act to suppress the target,especially in responses to stressful condition,but it seems to be the primary effect in phenolic allelopathy.We still wonder how the exudates from rice root,which were released into rhizosphere soil,are transformed by soil microorganism to produce the higher secondary effect of phenolic allelopathy in the suppression of weeds.Therefore,the authors suggest that rhizosphere biologic properties of allelopathy in rice and its mechanism are being the key research areas in the world now,and systems biology and its approaches,such as metagenomics and metaproteomics,would be helpful to reveal the process and its molecular ecological mechanism regarding rhizospheric biology of rice allelopathy.Wenxiong LIN Changxun FANG Ting CHEN Ruiyu LIN Jun XIONG Haibin WANG 2010Frontiers in Biology2010,5,3:5
9In vitro effects of sodium hyaluronate on the proliferation and the apoptosis in chondrocytes from patients with Kashin-Beck disease and osteoarthritis显示文摘Objective:To identify the in vitro effects of sodium hyaluronate(HA) on the proliferation and the apoptosis of chondrocytes from patients with Kashin-Beck disease(KBD) and osteoarthritis(OA). Methods:Samples of articular cartilages from KBD and OA patients, as well as healthy volunteers(6 subjects in each of the 3 groups) were dissected, digested with collagenase and the cells cultured in monolayers. Chondrocytes from each sample were assigned to an untreated group and two HA-treated groups: H0(no HA), H100(HA, 0.1 g/L) and H500(HA, 0.5 g/L). The first passage chondrocytes were used to observe proliferation using the MTT assay, and apoptosis by flow cytometry through Annexin V/PI staining. Results:HA promoted proliferation of chondrocytes in all the three groups, and in KBD and OA groups, for cells cultured for 4 and 6 days, H500 significantly promoted the cell proliferation. The apoptotic rates of both KBD and OA group chondrocytes were in the order H500 < HA100 < H0. Conclusion:Sodium hyaluronate administration has a dose-dependent in vitro effect to promote proliferation and inhibit apoptosis of chondrocytes from patients with KBD and OA.Zongqiang Gao Xiong Guo Chen Duan Weijuan Ma Peng Xu Ruiyu Liu Qisheng Gu Junchang Chen 2009Journal of Nanjing Medical University2009,23,2:5
10Effects of cerium precursors on surface properties of mesoporous CeMnO_x catalysts for toluene combustion显示文摘Mesoporous CeMnOx composite oxides catalysts were prepared by surfactant-assisted co-precipitation method and used for the catalytic oxidation of toluene.The effect of different cerium precursors[Ce(NO3)3 and(NH4)2 Ce(NO3)6] on catalyst structure,surface properties and toluene combustion activities of mesoporous CeMnOx catalysts were investigated.The Ce(Ⅲ)MnOx catalyst prepared from Ce(NO3)3 precursor shows higher catalytic activity,with a 90% conversion temperature of 240℃,which is better than the Ce(Ⅳ)MnOx catalyst derived from[(NH4)2 Ce(NO3)6] precursor.On the basis of characterizations,it reveals that abundant surface content of Mn4+,better redox behavior and larger concentration of surface active oxygen species are responsible for the excellent catalytic performance.Changyu Zhang Wei Chu Feng Chen Lei Li Ruiyu Jiang Jinlong Yan 2020Journal of Rare Earths2020,38,1:4
11Preparation and characterization of Mn/MgAlFe as transfer catalyst for SO_x abatement显示文摘A series of manganese-promoted MgAlFe mixed oxides, used as sulfur transfer catalysts, were prepared by acid-processed gelatin method and characterized by TGA-DTA, XRD, N2 adsorption-desorption and FT-IR techniques. It was found that the sulfur transfer catalysts with 0.5?3.0 wt% manganese showed its good dispersion in the precursor. The novel Mn/MgAlFe catalysts with 0.5?5.0 wt% manganese oxide showed a high oxidative adsorption rate and sulfur adsorption capacity, and 5.0 wt% Mn/MgAlFe sample was superior to the others for SO2 removal. Moreover, the presence of CO had no obvious effect on the adsorption activity of sulfur transfer catalysts for SO2 uptake.Ruiyu Jiang Honghong Shan Chunyi Li Chaohe Yang 2011Journal of Natural Gas Chemistry2011,20,2:4
12Application of shear-sensitive liquid crystal coating to visualization of transition and reattachment in compressor cascade显示文摘The present paper aims at introducing Shear-Sensitive Liquid Crystal Coating(SSLCC)technology into compressor cascade measurement for the first time and serves as a basis for better understanding of the influence from the boundary layers. Optical path layout, which is the most significant difficulty in internal flow field measurement, will be solved in this paper by selfdesigned image acquisition device. Massive experiments with different Mach number and incidence are conducted at a continuous subsonic cascade wind tunnel to capture the boundary layer phenomenon. Image processing methods, such as Three-Dimensional(3-D) reconstruction and Hue conversion, are used to improve the accuracy for transition position detection. The analysis of the color-images indicates that complex flow phenomena including transition, flow separation,and reattachment are captured successfully, and the effect of Mach number and incidence on the boundary layer flow is also discussed. The results show that: the Mach number has a significant effect on transition position; the incidence has little effect on transition position, but it has a great impact on the transition distance and leading-edge separation; influenced by the end-walls, the reattachment occurs in advance under positive angle of attack conditions.Ruiyu LI Limin GAO Shuai ZHANG Yongzeng LI Tianyu GAO 2018Chinese Journal of Aeronautics2018,31,11:4
13EFFECTS OF DIABETES ON HEARING AND COCHLEAR STRUCTURES显示文摘Diabetes mellitus(DM) is a chronic systemic disease characterized by hyperglycemia, with various pathogenic mechanisms. From absolute or relative insulin deficiency, patients with DM often demonstrate various levels of metabolic disorders. Major clinical manifestations of DM include metabolic disorders, vascular lesions, circulatory disturbances and neurologic complications. Along with advances in DM research, reports of DM related tinnitus and hearing impairment have increased continuously. Research on DM related auditory system dysfunction has focused on cochlear microcirculation, cellular homeostasis, genetics and aging. Cochlear microcirculation plays an important role in cochlear physiology and its disorders are associated with many inner ear diseases. Ischemia and subsequent reperfusion seen in cochlear microcirculation disorders are important factors in hearing damage. Understanding cochlear microcirculation and structural as well as functional changes in DM patients with hearing loss and their causal factors will help reveal pathogenic mechanisms in diabetic hearing loss and provide new ideas in developing interventions and preventing damages caused by diabetes.Li Xipeng Li Ruiyu Li Meng Zhang Yanzhuo Guo Kaosan Wu Liping 2013Journal of Otology2013,8,2:3
14Distributed UAV swarm based on spatial grid model显示文摘Unmanned Aerial Vehicle(UAV)swarm has become the inevitable trend of development,which will enjoy broad prospects to be applied in the future.However,the change of UAV application mode will certainly bring new technical challenges in the flight management,environmental perception,collaborative control as well as other fields.This paper considers that it can be an effective solution to realize the unified management of spatial information on the UAV platform by adopting the spatial grid model represented by the Geo SOT-3D,and to reduce the workload of flight management,airborne environmental perception,and ranging in the neighborhood through the association and query of all spatial grid data.Bangkui FAN Zhiwei ZHANG Ruiyu ZHANG 2020Chinese Journal of Aeronautics2020,33,11:3
15Effect of H_2 Reduction Temperature on the Properties of Reduced Graphene Oxide and Copper Matrix Composites显示文摘Reduced graphene oxide(RGO) and copper composites(RGO/Cu) were successfully fabricated based on a molecular-level mixing method(MLM). The composite powders were reduced in H2 at 350, 450, and 550 °C and then consolidated by spark plasma sintering(SPS) in order to evaluate the effect of H2 reduction temperature on the properties of the composites. The results indicate that the strengths of the composite decrease with the increase of H2 reduction temperature, while the electrical conductivity reaches its maximum at 450 °C and minimum at 550 °C. Hot rolling could benefit the electrical conductivity. The yield strength of the RGO/Cu composite reduced to 337 MPa at 350 °C. The electrical conductivity of the RGO/Cu composite reduced at 450 °C after hot rolling reaches 60.26% IACS. The properties of the RGO/Cu composites can be designed by adjusting the reduction degree of RGO and by hot rolling.Lidong Wang Ye Cui Ruiyu Li Guojian Cao Bin Li Weidong Fei 2014Acta Metallurgica Sinica(English Letters)2014,27,5:3
16A stretchable triboelectric generator with coplanar integration design of energy harvesting and strain sensing显示文摘The rapid development of flexible triboelectric nanogenerators(TENGs)has become an alternative to batteries for wearable devices.Stretchable,multifunctional,and low-cost are the primary development directions for these wearable devices based on TENG.Herein,a stretchable triboelectric generator with coplanar integration was designed for energy harvesting and force sensing.The industrial conductive silicone and silicone were used to fabricate the TENG with a thickness of less than 0.9 mm.When the elongation was less than 150%,TENG exhibited excellent linear characteristics in the resistance-tensile strain correspondence,and the coefficient of determination was 0.99.This stretchable TENG with a sufficient contact area of 9 cm^(2) could generate a short-circuit current of 2μA when it was in contact with the skin.Lastly,an intelligent tension monitoring wearable device that can effectively measure the tensile force was developed.Such a stretchable,coplanar integration-based,and low-cost wearable device has excellent applicability in wearable electronics.WU Bin ZHANG ZengXing XUE XiaoBin HAO CongCong ZHANG WenJun BI RuiYu WANG Qiang XUE ChenYang 2022Science China(Technological Sciences)2022,65,1:3
17Effect of steam explosion and microbial fermentation on cellulose and lignin degradation of corn stover显示文摘Juan Chang Wei Cheng Qingqiang Yin Ruiyu Zuo Andong Song Qiuhong Zheng Ping Wang Xiao Wang Junxi Liu 2011Bioresource Technology2011,,:3
18Evaluation of the use of sublevel open stoping in the mining of moderately dipping medium-thick orebodies显示文摘The flow of blasted ore during mining of moderately dipping medium-thick orebodies is a challenge.Selecting a suitable mining system for such ore bodies is difficult.This paper proposes a diamond layout sublevel open stoping system using fan blastholes with backfilling to mine such orebodies.To evaluate the performance of system the relationships between ore recovery and stope footwall dip angle,footwall surface roughness,drawpoint spacing and production blast ring burden were investigated.An ore recovery data set from 81 laboratory physical model experiments was established from combinations of the listed factors.Various modules in a back propagation neural network structure were compared,and an optimal network structure identified.An ore recovery backpropagation neural network(BPNN)forecast model was developed.Using the model and sensitivity analysis of the factors affecting the proposed open stope mining system,the significance of each factor on ore recovery was studied.The study results were applied to a case study at the Shandong Gold Group Jiaojia Gold Mine.The results showed that the application of a BPNN and sensitivity analysis models for ore recovery prediction in the proposed mining system and field experimental results confirm that the suggested mining method is feasible.Shuai Xu Ruiyu Liang Fidelis TSuorineni Yuanhui Li 2021International Journal of Mining Science and Technology2021,31,2:3
19Life Prediction Model of Machine Tool based on Deep Learning显示文摘In view of the shortage of traditional life prediction methods for machine tools,such as low accuracy of life prediction and few samples basis attributes,a life prediction model of machine tools combined with machine tool attributes is proposed.The life prediction model of machine tool adopts KL dispersion distribution theory,uses modal superposition method to carry out machine tool life analysis,calculates the theoretical life of machine tool,and then carries on the simulation,obtains the machine tool life prediction value.Compared with the traditional method of machine tool life prediction,the model is based on the application life fatigue damage model,which superimposes the service times and maintenance cycle of the machine tool,derives the influence factor of machine tool life,and obtains the linear relationship between the influence factor of machine tool life and the life of machine tool.The influence factor of machine tool life is introduced as the life prediction parameter of machine tool.The data transformation relationship of HT300 parts is constructed.The original part data is enhanced.The effective training set is obtained.The life prediction model of machine tool based on deep learning is completed.The quantitative analysis of machine tool life is carried out.The experiment of machine tool life prediction using training data set proves the validity of the model.Regression test was carried out on the training data set to reflect the robustness of the model.The prediction accuracy of the model is further verified by Weibull test.HE Jiawei ZHAO Chendi GAO Ruiyu LIU Xuehui WANG Xue 2021International Journal of Plant Engineering and Management2021,26,1:2
20Construction of interesting organic supramolecular structures with synthons cooperation in the cocrystals of 1H-benzotriazole and hydroxybenzoic acids显示文摘Multifunctional molecules are capable of assembling via different supramolecular synthons,or hydrogen bond motifs,between the same or different functional groups,leading to the possibility of cocrystal.Utilization of the interplay of dimensionality(1-D,2-D and 3-D),orientation of functional groups of the building blocks,influence of rigid/flexible linking groups,and weak interactions provides an interesting route for the creation of novel supramolecular architectures in the crystal lattice.N-unsubstituted 1H-benzotriazole and carboxylic acid,being self-complementary molecules,offer a broad scope of study of binary compounds based on the complementary combination of H-bonding/donating sites.We report here the construction of three extended molecular networks in cocrystals of the carboxylic acid group of the acid and the 1H-benzotriazole triazole moiety.We have been able to identify four major supramolecualr synthons that would be helpful in the prediction of structural motifs for these kinds of studies.Interestingly,these heterosynthons are strikingly similar,to those of the homosynthons of the individual functional groups.The nature of the aza groups helps to enhance the overall volume of the crystal lattice thus leading to the formation of various supramolecular assemblies.Thermal stability of these compounds has been investigated by thermogravimetric analysis(TGA) of mass loss.WANG Lei ZHAO Lei XUE RuiYu LU XiFeng WEN YongHong YANG Yu 2012Science China Chemistry2012,55,12:2
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