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| 1 | MicroRNA regulation of innate immune responses in epithelial cells显示文摘Mucosal surface epithelial cells are equipped with several defense mechanisms that guard against pathogens.Recent studies indicate that microRNAs(miRNAs)mediate post-transcriptional gene suppression and may be a critical component of the complex regulatory networks in epithelial immune responses.Transcription of miRNA genes in epithelial cells can be elaborately controlled through pathogen recognition receptors,such as Toll-like receptors(TLRs),and associated nuclear factor kappaB(NF-kB)and mitogen-activated protein kinase(MAPK)pathways,and ultimately nuclear transcription factor associated-transactivation and transrepression.Activation of these intracellular signaling pathways may also modulate the process of miRNA maturation.Functionally,miRNAs may modulate epithelial immune responses at every step of the innate immune network,including production and release of cytokines/chemokines,expression of adhesion and costimulatory molecules,shuttling of miRNAs through release of exosomes and feedback regulation of immune homeostasis.Therefore,miRNAs act as critical regulators to the fine-tuning of epithelial immune responses. | Rui Zhou Steven P O’Hara Xian-Ming Chen | 2011 | Cellular & Molecular Immunology2011，8，5： | 13 |
| 2 | Differences in atheroma between Caucasian and Asian subjects with anterior stroke:A vessel wall MRI study显示文摘Background and purpose While extracranial carotid artery stenosis is more common among Caucasians and intracranial artery stenosis is more common among Asians,the differences in atherosclerotic plaque characteristics have not yet been extensively examined.We sought to investigate plaque location and characteristics within extracranial carotid and intracranial arteries in symptomatic Caucasians and Chinese using vessel wall MRI.Methods Subjects with recent anterior circulation ischaemic stroke were recruited and imaged at two sites in the USA and China using similar protocols.Both extracranial carotid and intracranial arteries were reviewed to determine plaque location and characteristics.Results The prevalence of extracranial carotid plaque in Caucasians and Chinese was 73.1%and 49.1%,respectively(p=0.055).Prevalence of intracranial plaque was 38.5%and 69.1%in Caucasians and Chinese,respectively(p=0.02).Furthermore,42% of Caucasians and 16%of Chinese had high-risk plaque(HRP)features(intraplaque haemorrhage,luminal surface disruption)in the extracranial carotid artery(p=0.03).The prevalence of HRP features in intracranial arteries was not significantly different between the two cohorts(4%vs 11%;p=0.42).Conclusions Differences in the location and characteristics of cerebrovascular atherosclerosis were identified by vessel wall MRI in US Caucasian and Chinese subjects with recent anterior circulation ischaemic stroke.Extracranial carotid plaques with HRP features were more common in Caucasians.Intracranial plaques were more common in Chinese subjects,but no significant difference between the two cohorts in intracranial HRP prevalence was found.Larger studies using vessel wall imaging to investigate racial differences in cerebrovascular disease may inform underlying mechanisms of HRP development and may ultimately help guide appropriate therapy. | Hiroko Watase Mi Shen Binbin Sui Peiyi Gao Dong Zhang Jie Sun Niranjan Balu Daniel S Hippe Gail P Jarvik Xihai Zhao Rui Li Shuo Chen Chun Yuan Thomas S Hatsukami | 2021 | Stroke & Vascular Neurology2021，6，1： | 4 |
| 3 | Metallothioneins are required for formation of cross-adaptation response to neurobehavioral toxicity from lead and mereury exposure in nematodes 显示文摘 | Ye B P Rui Q Wu Q | 2010 | PLoS One2010，5，14： | 1 |
| 4 | Transfer matrix method for linear multibody system 显示文摘 | Rui X T Wang G P Lu Y Q | 2008 | Multibody System Dynamics2008，19，3： | 1 |
| 5 | Public Governance and Corporate Finance: Evidence from Corruption Cases显示文摘 | FAN J P RUI O M ZHAO M | 2008 | Journal of Comparative Economics2008，36，3： | 1 |
| 6 | Carrier aggregation for LTE -advanced: uplink multiple access and transmission en- hancement features显示文摘 | Rui Y Cheng P Li M Q | 2013 | IEEE Wireless Communications2013，20，4： | 1 |
| 7 | Adaptive alpha-trimmed mean filters under deviations from assumed noise model显示文摘 | Oten Remzi De Figueiredo Rui J P | 2004 | IEEE Transactions on Image Processing2004，13，5： | 1 |
| 8 | Surgical treatment for patients with Krukenberg tumor of stomach origin: Clinical outcome and prognostic factors analysis 显示文摘 | Wei P Rui XH Rong J | | PLoS One0，8，68： | 1 |
| 9 | Figures of Merit of a SERS Method for Sudan I Determination at Traces Levels显示文摘 | L pez M I Ruis nchez I Callao M P | 2013 | Spectrochim Acta2013，111，： | 1 |
| 10 | How ownership and corporate governance influence chief executive pay in Chi- na's listed firms 显示文摘 | Firth M Fung P M Y Rui O M | 2007 | Journal of Business Research2007，60，7： | 1 |
| 11 | The choice of a health care provider in Efitrea 显示文摘 | Habtom G Ruys P | 2007 | Health Policy2007，，80： | 1 |
| 12 | Comparative study on the effects of L-methionine or 2-hydroxy-4-(methylthio) butanoic acid as dietary methionine source on growth performance and anti-oxidative responses of turbot (Psetta maxima)显示文摘 | Rui M Hou H P Mai K S | 2013 | Aquaculture2013，12，： | 1 |
| 13 | High-throughput drilling of titanium alloys显示文摘 | LI Rui HEGDE P SHIH A J | | 0，，01： | 1 |
| 14 | Efficiency and its determinants in Portuguese hotels in the Algarve显示文摘 | Ricardo O Maria Isabel P Rui C M | 2013 | Tourism Management2013，36，2： | 1 |
| 15 | Succession of bacterial populations during plant residue decomposition in rice field soil显示文摘 | RUI J P PENG J J LU Y H | 2009 | Applied and Environmental Microbiology2009，75，14： | 1 |
| 16 | V2O3 modified LiFePO4/C composite with improved electrochemical performance显示文摘 | Jin Y Yang C P Rui X H | | 0，，13： | 1 |
| 17 | How ownership and corporate governance influence chief executive pay in China~ listed finns显示文摘 | Firth M Fung P M Y Rui O M | 2007 | Jour- nal of Business Research2007，60，7： | 1 |
| 18 | Study of the Quality of Several Asymptotic and Near-exact Approximations Based on Moments for the Distribution of the WilEs Lambda Statistic显示文摘 | Alberto Rui P Carlos A Coelho | 2007 | Journal of Statistical Planning and Inference2007，137，5： | 1 |
| 19 | Firm Performance, Governance Structure, and Top Management Turnover in a Transitional Economy显示文摘 | FIRTH M FUNG P RUI O | 2006 | Journal of Management Studies2006，43，6： | 1 |
| 20 | Acute impairment of mitochondrial trafficking by beta-amyloid peptides in hippocampal neurons显示文摘 | Rui Y Tiwari P Xie Z | 2006 | J Neurosci2006，26，10： | 1 |
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