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| 1 | Expression analysis of a-smooth muscle actin and tenascin-C in the periodontal ligament under orthodontic loading or in vitro culture显示文摘α-smooth muscle actin(α-SMA) and tenascin-C are stress-induced phenotypic features of myofibroblasts. The expression levels of these two proteins closely correlate with the extracellular mechanical microenvironment. We investigated how the expression of α-SMA and tenascin-C was altered in the periodontal ligament(PDL) under orthodontic loading to indirectly reveal the intrinsic mechanical microenvironment in the PDL. In this study, we demonstrated the synergistic effects of transforming growth factor-β1(TGF-β1) and mechanical tensile or compressive stress on myofibroblast differentiation from human periodontal ligament cells(h PDLCs). The h PDLCs under higher tensile or compressive stress significantly increased their levels of α-SMA and tenascin-C compared with those under lower tensile or compressive stress. A similar trend was observed in the tension and compression areas of the PDL under continuous light or heavy orthodontic load in rats. During the time-course analysis of expression, we observed that an increase in α-SMA levels was matched by an increase in tenascin-C levels in the PDL under orthodontic load in vivo. The time-dependent variation of α-SMA and tenascin-C expression in the PDL may indicate the time-dependent variation of intrinsic stress under constant extrinsic loading. | Hui Xu Ding Bai L-Bruno Ruest Jian Q Feng Yong-Wen Guo Ye Tian Yan Jing Yao He Xiang-Long Han | 2015 | International Journal of Oral Science2015，7，4： | 5 |
| 2 | Bayesian data analysis to quantify the uncertainty of intact rock strength显示文摘One of the main difficulties in the geotechnical design process lies in dealing with uncertainty. Uncertainty is associated with natural variation of properties, and the imprecision and unpredictability caused by insufficient information on parameters or models. Probabilistic methods are normally used to quantify uncertainty. However, the frequentist approach commonly used for this purpose has some drawbacks.First, it lacks a formal framework for incorporating knowledge not represented by data. Second, it has limitations in providing a proper measure of the confidence of parameters inferred from data. The Bayesian approach offers a better framework for treating uncertainty in geotechnical design. The advantages of the Bayesian approach for uncertainty quantification are highlighted in this paper with the Bayesian regression analysis of laboratory test data to infer the intact rock strength parameters σ_(ci) and m_i used in the Hoek-Brown strength criterion. Two case examples are used to illustrate different aspects of the Bayesian methodology and to contrast the approach with a frequentist approach represented by the nonlinear least squares(NLLS) method. The paper discusses the use of a Student's t-distribution versus a normal distribution to handle outliers, the consideration of absolute versus relative residuals, and the comparison of quality of fitting results based on standard errors and Bayes factors. Uncertainty quantification with confidence and prediction intervals of the frequentist approach is compared with that based on scatter plots and bands of fitted envelopes of the Bayesian approach. Finally, the Bayesian method is extended to consider two improvements of the fitting analysis. The first is the case in which the Hoek-Brown parameter, a, is treated as a variable to improve the fitting in the triaxial region. The second is the incorporation of the uncertainty in the estimation of the direct tensile strength from Brazilian test results within the overall evaluation of the intact rock strength. | Luis Fernando Contreras Edwin T.Brown Marc Ruest | 2018 | Journal of Rock Mechanics and Geotechnical Engineering2018，10，1： | 4 |
| 3 | Oral decontamination for prevention of pneumonia in mechanically ventilated adults:systematic review and meta-analysis显示文摘 | Chan EY Ruest A Meade MO | 2007 | BMJ2007，334，7599： | 1 |
| 4 | Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2 显示文摘 | Owen ID Ruest P'I Fry DW | 1999 | Mol Cell Biol1999，19，7： | 1 |
| 5 | Fak regulates tyrosine phosphorylation of CAS,paxillin,and PYK2 in cells expressing v-Src,but is not a critical determinant of v-Src transformation显示文摘 | Roy S Ruest PJ Hanks SK | 2002 | J Cell Biochem2002，84，： | 1 |
| 6 | Oral decontamination for prevention of pneumonia in mechanically ventilated adults:systematic review and meta-analysis显示文摘 | Chan EY Ruest A Meade MO | 2007 | BMJ2007，334，7599： | 1 |
| 7 | Oral decon-tamination for prevention of pneumonia in mechanically ventila-ted adults : Systematic review and meta - analysis显示文摘 | Ee Yuee Chan Annie Ruest Maureen Meade ^ al | 2007 | BMJ2007，，： | 1 |
| 8 | Oral decontamination for preven- tion of pneumonia in mechanically ventilated adults: systematic review and meta-analysis显示文摘 | Chan EY Ruest A Meade MO | 2007 | BMJ2007，334，7599： | 1 |
| 9 | Comparison of the Directigen Flu A +B Test, the QuickVue Influenza test, and clinical cases definition to virus culture and reverse transcription-RCR for rapid diagnosis of influenza virus infection 显示文摘 | Ruest A Michaud S Deslands S | 2003 | J Clin Microbiol2003，41，8： | 1 |
| 10 | Oral decontamination forprevention of pneumonia in mechanically ventilated adults:systematic review and meta-analysis显示文摘 | Chan EY Ruest A Meade MO | 2007 | BMJ2007，334，7599： | 1 |
| 11 | Dlx5/6-enhancer directed expression of Cre recombinase in the pharyngeal arches and brain显示文摘 | Ruest L B Hammer R E Yanagisawa M | 2003 | Genesis2003，37，4： | 1 |
| 12 | Oral decontami- nation for prevention of pneumonia in mechanically ven- tilated adults:Systematic review and meta-analysis显示文摘 | Chan E Y Ruest A Meade M O | 2007 | BMJ2007，334，7599： | 1 |
| 13 | Elucidating timing and function of endothelin-A receptor signaling during craniofacial development using neural crest cell-specific gene deletion and receptor antagonism显示文摘 | Ruest L B Clouthier D E | 2009 | Dev Biol2009，328，1： | 1 |
| 14 | Oral decontamination for prevention of pneumonia in mechanically ventilated adults: sys- tematic review and meta - analysis显示文摘 | Chan EY Ruest A Meade MO | 2007 | BMJ2007，334，： | 1 |
| 15 | Peptide elongation factor eEF1A-2/S1 expression in cultured differentiated myotubes and its protective effect against caspase-3-mediated apoptosis显示文摘 | Ruest L B Marcotte R Wang E | 2002 | J Biol Chem2002，277，： | 1 |
| 16 | Peptide elongation factor eEF1 A-2/S1 expression in cultured differentiated myotubes and its protective effect against caspase-3-mediated apoptosis显示文摘 | Ruest L B Marcotte R Eugenia W | | 0，，07： | 1 |
| 17 | Cardiopulmonary bypass induces significant platelet activation in children undergoing open-heart surge显示文摘 | Ruest P Iortie L | 2004 | Eur J Anaesthesiol2004，21，12： | 1 |
| 18 | Phosphospecific Antibodies Reveal Focal Adhesion Kinase Activation Loop Phosphorylation in Nascent and Mature Focal Adhesions and Requirement for the Autophosphorylation Site显示文摘 | RUEST P J ROY S SHI E | 2000 | Cell Growth Differ2000，11，1： | 1 |
| 19 | Cardiopulmonary bypass induces significant platelet activation in children undergoing open-heart surgery显示文摘 | GUAY J RUEST P LORTIE L | 2004 | Eur J Anaesthesiol2004，21，12： | 1 |
| 20 | FAK regulates tyrosine phesphorylatian of CAS,paxillin,and PYK2 in cells expressing v-Src,but is not a critical determinant of v-Src transformation显示文摘 | Ruest PJ Hanks SK | 2002 | J Cell Biochem2002，84，2： | 1 |
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