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| 1 | 胆固醇结石病人肝脏脂质代谢异常的分子生物学研究显示文摘目的:研究导致胆石病人胆汁胆固醇过饱和的肝脏胆固醇和胆汁酸代谢途径中的分子生物学改变。方法:收集22例胆石病人和13例无胆石病的对照病人肝脏活检组织、胆囊胆汁和血浆。采用实时定量PCR检测肝脏基因表达,采用Western印迹法测定蛋白含量。结果:胆石病人较对照组ABCG5/ABCG8和LXRα基因的mRNA表达水平分别增加51%、59%和102%。肝脏SRBI的mRNA和蛋白含量均增加。结论:胆石病人ABCG5/ABCG8基因表达上调,可能与LXRα表达增加促进相关,这些异常是导致胆汁胆固醇过饱和的原因。此外,胆汁中过多的胆固醇可能来源于经肝脏高密度脂蛋白受体SRBI的摄取,而不是由于肝脏合成和酯化的异常。 | 蒋兆彦 姜翀弋 胡海 所广军 Paolo Parini Gsta Eggertsen Matthew A Davis Lawrence L Rudel Curt Einarsson 韩天权 张圣道 | 2007 | 外科理论与实践2007，12，5： | 4 |
| 2 | Aroma volatile biosynthesis in apples affected by 1-MCP and methyl jasmonate显示文摘 | S. Kondo S. Setha D.R. Rudell D.A. Buchanan J.P. Mattheis | 2004 | Postharvest Biology and Technology2004，，1： | 3 |
| 3 | Aroma volatile biosynthesis in apples affected by 1-MCP and methyl jasmonate显示文摘 | KONDO S SETHA S RUDELL D R | 2005 | Postharvest Biology and Technology2005，36，： | 1 |
| 4 | Urbanization, Roads, and Rural Population Change in the Ecuadorian Andes显示文摘 | Rudel and Richards | 1990 | Studies in Comparative Inter- national Development1990，，3： | 1 |
| 5 | Determination of cholesterol using o-phthalaldehyde显示文摘 | Rudel L L Morris M D | 1973 | J Lipid Res1973，14，： | 1 |
| 6 | LDL cholesteryl oleate as a predictor for atherosclerosis:evidence from human and animal studies on dietary fat显示文摘 | Degirolamo C Shelness GS Rudel LL | 2009 | J Lipid Res2009，，： | 1 |
| 7 | Aroma volatile biosynthesis in apples affected by 1-MCP and methyl jasmonate显示文摘 | KONDO S SETHA S RUDELL D R | 2005 | Posthar vest Biology and Technology2005，36，： | 1 |
| 8 | Phthalates, alkylphenols, pesticides, polybrominated diphenyl ethers, and other endocrine-disrupting compounds in indoor air and dust 显示文摘 | Rudel RA Camann DE Spengler JD | 2003 | Environ Sci Teehnol2003，37，20： | 1 |
| 9 | Phthalates, alkylphenols, pesticides, polybrominated diphenyl ethers, and other endocrine-disrupting compounds in indoor air and dust显示文摘 | RUDEL R A CAMANN D E SPENGLER J D | 2003 | Environmental Science & Technology2003，37，20： | 1 |
| 10 | Determination of cholesterol using o-phthalaldehyde 显示文摘 | Rudell L L Morris M D | 1973 | Journal of Lipid Research1973，14，： | 1 |
| 11 | Genotype-phenotype correlations in human skeletal muscle sodium channel diseases 显示文摘 | Rudel R Ricker K Lehmann-Horn F | 1993 | Arch Neurol1993，50，11： | 1 |
| 12 | A 12 bit 200 MS/s zero-crossing-based pipelined ADC with early sub-ADC decision and output residue background cali- bration 显示文摘 | Shin S K Rudell J C Daly D C | 2014 | IEE[ J Sol Sta Circ2014，49，6： | 1 |
| 13 | Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome显示文摘 | FESSLER MB RUDEL LL BROWNJM | 2009 | Curr Opin Lipidol2009，20，5： | 1 |
| 14 | Predicting health effects of exposure to compounds with estrogenic activity: methodological issues 显示文摘 | RUDEL R | 1997 | Environ Health Per- spect1997，105，3： | 1 |
| 15 | Forest transitions : Towards a global understanding of land use change 显示文摘 | Rudel T K Coomes O T Moran E | 2005 | Global Environmental Change2005，15，： | 1 |
| 16 | Mobilization of cytoplasmic CE droplets by overexpression of human macrophage cholesteryl ester hydrolase显示文摘 | Ghosh S St Clair RW Rudel LL | 2003 | J Lipid Res2003，44，10： | 1 |
| 17 | Population, Development, and Tropical Defor- estation: A Cross-National Study 显示文摘 | Rudel T | 2002 | Rural Sociology2002，54，3： | 1 |
| 18 | Semivolatile endocrine-disrupting compounds in paired indoor and outdoor air in two Northern California communities显示文摘 | Rudel R A Dodson R E Perovich L J | 2010 | Environmental Science & Technology2010，44，17： | 1 |
| 19 | Metabolic changes in 1-methyleydo- propene (1-MCP)-treated 'Empire' apple fruit during storage显示文摘 | Lee J Rudell D R Davies P J | 2012 | Metabolo- mics2012，8，： | 1 |
| 20 | Survey of patterns, lev- els, and trends of perfluorinated compounds in aquatic organisms and bird eggs from representative German ecosystems 显示文摘 | Rudel H Muller J | 2011 | Environ Sci Pollut Res2011，，18： | 1 |
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