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| 1 | Preservation of platelet function in patients with cirrhosis and thrombocytopenia undergoing esophageal variceal ligation显示文摘Background:Thrombocytopenia is a possible risk factor for bleeding after band ligation of esophageal varices.However,elevated von Willebrand factor(VWF)in cirrhosis improves platelet function and could decrease this risk.Our objective was to assess platelet function in patients with cirrhosis undergoing esophageal variceal ligation(EVL).Methods:The assessment consisted of platelet count,antigen and activity of VWF and VWF-cleaving protease ADAMTS-13 activity,and a platelet adhesion and aggregation test simulating vascular flow in vivo(Impact-RR)prior to EVL.Results:Totally 111 patients were divided into three groups according to platelet count:(1)<50×109/L(n=38,34.2%);(2)50×109/L to 100×109/L(n=47,42.3%);and(3)>100×109/L(n=26,23.4%).No statistically significant difference was found in the aggregate size of platelets[group 1:41.0(31.8–67.3)μm 2;group 2:47.0(33.8–71.3)μm 2;and group 3:47.0(34.0–66.0)μm 2;P=0.60]and no significant correlation was found between aggregate size and platelet count(Spearman r=0.07;P=0.47).Surface coverage was 4.1%(2.8%–6.7%),8.5%(4.0%–10.0%),and 9.0%(7.1%–12.0%)(P<0.001)in groups 1,2 and 3,respectively and correlated with platelet count(Spearman r=0.39;P<0.0001).There was no significant difference between groups in VWF or ADAMTS-13.Post-EVL bleeding occurred in six(5.4%)patients(n=2 in group 1,n=1 in group 2,and n=3 in group 3;P=0.32).Patients with bleeding had higher MELD scores[15.0(11.3–20.3)versus 12.0(10.0–15.0);P=0.025],but no difference was demonstrated for platelet function parameters.Conclusion:Platelet function is preserved even in the presence of thrombocytopenia,including in the patients with post-EVL bleeding. | Evandro de Oliveira Souza Elbio Antonio D’Amico Tania Rubia Flores da Rocha Caroline Marcondes Ferreira Juliana Medeiros Batista Luiz Augusto CarneiroD’Albuquerque Flair Jose Carrilho Alberto Queiroz Farias | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，6： | 3 |
| 2 | Predation of yellow stem borer (YSB) by wolf spider显示文摘 | Rubia E G Almazan L P Heong K L | 1990 | International Rice Research Newsletter1990，15，4： | 1 |
| 3 | Dissociated Functional Brain Abnormalities of Inhibition in Boys With Pure Conduct Disorder and in Boys With Pure Attention Deficit Hyperactivity Disorder显示文摘 | Rubia Katya Halari Rozmin Smith Anna B Mohammed Majeed Scott Steven Giampietro Vincent Taylor Eric Brammer Michael J | 2008 | The American Journal of Psychiatry2008，，7： | 1 |
| 4 | Temperature conversion (mesophilic to thermophilic) of municipal sludge digestion 显示文摘 | De la Rubia M A Romero L I Sales D | 2005 | Aiche Journal2005，51，9： | 1 |
| 5 | FLAG-IDA regimen (fludarabine,cytarabine,idarubicin and G-CSF) in the treatment of patients with high-risk myeloid malignancies 显示文摘 | de la Rubia J Regadera A Martin G | 2002 | Leuk Res2002，26，8： | 1 |
| 6 | Microwave assisted efficient preparation of novel car- bohydrate tetrazole derivatives 显示文摘 | Mara Rubia Couri Inacio Luduvico Leandro Santos | 2007 | Carbohydrate Re- search2007，342，8： | 1 |
| 7 | Methylphenidate norma- lises activation and functional connectivity deficits in atten tion and motivation networks in medication-naive children with ADHD during a rewarded continuous performance task 显示文摘 | Rubia K Halari R Cubillo A | 2009 | Neuropharmacology2009，57，78： | 1 |
| 8 | Removal of natural organic matter and THM formation potential by ultra-and nanofiltration of surface water显示文摘 | Rubia Rodríguez M León V M | 2008 | Water Research2008，42，3： | 1 |
| 9 | Dielectric behavior of Hfdoped CaCu3 Ti4 012 ceramics obtained by conventional synthesis and reactive sintering显示文摘 | Rubia M A Leret P Campo A D | 2012 | J Eur Ceram Soc2012，32，8： | 1 |
| 10 | Cardiac tamponade and cardiogenic shock as a manifestation of all-trans retinoic acid syndrome: an association not previously reported 显示文摘 | dela Rubia Jimenez C | 1997 | Haematology1997，82，4： | 1 |
| 11 | Validation of a self- efficiency scale for the prevention of AIDS among adolescents显示文摘 | L6PEZ-ROSALES F MORAL-DE L RUBIA J | 2001 | Sa- lud Publica Mex2001，43，5： | 1 |
| 12 | Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRI 显示文摘 | Rubia K Lee F Cleare A J | 2005 | Psyehopharmacology2005，179，4： | 1 |
| 13 | Base excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1显示文摘 | Dantzer F de La Rubia G Menissier-De Murcia J | 2000 | Biochemistry2000，39，25： | 1 |
| 14 | Ab-initio pseudopotential calculation of B diffusion and paring in Si 显示文摘 | Zhu J Rubia T D Yang L H | 1996 | Phys Rev B1996，54，7： | 1 |
| 15 | QTc in- terval lengthening is related to CYP2D6 hydroxyl-ation capacity and plasma concentration of thio- ridazine in patients显示文摘 | Llerena A Berecz R de la Rubia A | 2002 | J Psyehopharmacol2002，16，4： | 1 |
| 16 | Thick film ZnO based varistors prepared by screen printing显示文摘 | DE LA RUBIA LOPEZ M A PEITEADO M FERNANDEZ J F CABALLERO A C HOLC J DRNOVSEK S KUSCER D MACEK S KOSEC M | 2006 | J Eur Ceram Soc2006，26，14： | 1 |
| 17 | Factors influencing the collection of peripheral blood stem cells in patients with acute myeloblastic leukemia and non-myeloid malignancies 显示文摘 | Carral A de la Rubia J Martin G | 2003 | Leuk Res2003，27，1： | 1 |
| 18 | The dynamic approach to neurodevelopmental psychiatric disorders:use of fMRI combined with neuropsychology to elucidate the dynamics of psychiatric disorders,exemplified in ADHD and schizophrenia 显示文摘 | Rubia K | 2002 | Behavioural Brain Research2002，130，： | 1 |
| 19 | The Neurobiology of Meditation and Its Chinical Effectiveness in Paychiatric Disorders显示文摘 | Rubia K | 2009 | Biol Psychol2009，82，1： | 1 |
| 20 | Base excision repair is impaired in mammalian cells lacking poly(ADP-ribose)polymerase-1显示文摘 | Dantzer F de La Rubia G Ménissier-De Murcia H | | 0，，25： | 1 |
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