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| 1 | Huangqi Guizhi Wuwu Decoction for treating diabetic peripheral neuropathy:a meta-analysis of 16 randomized controlled trials显示文摘OBJECTIVE:This meta-analysis was performed to systematically assess the efficacy and safety of the Chinese herbal medicine Huangqi Guizhi Wuwu Decoction(HGWWD) for treating diabetic peripheral neuropathy.DATA SOURCES:Six electronic databases,including the Cochrane Library,MEDLINE database,Chinese Biomedical Database,Chinese National Knowledge Infrastructure Database,Chinese Science and Technique Journals Database,and the Wanfang Database,were search ed on the internet for randomized controlled trials published up until 1 December 2015.The search terms included 'Chinese herbal medicine','diabetic peripheral neuropathy' and 'randomized controlled trials' in Chinese and in English.DATA SELECTION:We included randomized controlled trials using HGWWD/modified HGWWD for the treatment group,without restriction for the control group.We assessed literature quality in accordance with the Cochrane Review Handbook.A random or a fixed effects model was used to analyze outcomes using Rev Man 5.2 software.OUTCOME MEASURES:The primary outcomes were changes in symptoms and nerve conduction velocities.The secondary outcomeswere fasting blood glucose and hemorheological indexes.RESULTS:Sixteen randomized controlled trials,with a total of 1,173 patients,were included.Meta-analysis revealed that the efficacy of HGWWD for diabetic peripheral neuropathy was significantly superior compared with the control treatment(i.e.,control group)(risk ratio = 0.36,95% confidence interval(CI):0.29–0.46,Z =8.33,P < 0.00001) Compared with the control group,there was an increase in median motor nerve conduction velocity(mean difference(MD) = 3.46,95%CI:1.88–5.04,Z = 4.30,P < 0.01) and median sensory nerve conduction velocity(MD = 3.30,95%CI:2.04–4.56,Z = 5.14,P < 0.01).There was also an increase in peroneal motor nerve conduction velocity(MD = 3.22,95%CI:2.45–3.98,Z = 8.21,P < 0.01) and peroneal sensory nerve conduction velocity(MD = 3.05,95%CI:2.01–4.09,Z = 5.75,P < 0.01) in the treatment groups.No significant difference in fasting blood glucose was found between the treatment groups and the control groups(MD =-0.12,95%CI:-0.42–0.19,Z = 0.76,P = 0.45).Plasma viscosity was significantly decreased after treatment(MD =-0.11,95%CI:-0.21 to-0.02,Z = 2.30,P = 0.02).No significant difference in fibrinogen was detectable(MD =-0.53,95%CI:-1.28–0.22,Z = 1.38,P = 0.17).Four trials reported that treatment groups experienced no adverse reactions.Adverse events were not mentioned in the other 12 trials.No trial reported the incidence of complications,quality of life outcomes,or health economics.CONCLUSION:HGWWD treatment improves diabetic neurologic symptoms and ameliorates nerve conduction velocities.Our study suggests that HGWWD may have significant therapeutic efficacy for the treatment of diabetic peripheral neuropathy.However,the methodological quality of the randomized controlled trials was generally low.Larger and better-designed randomized controlled trials are required to more reliably assess the clinical effectiveness of HGWWD. | Bing Pang Tian-yu Zhao Lin-hua Zhao Fang Wan Ru Ye Qiang Zhou Feng Tian Xiao-lin Tong | 2016 | Neural Regeneration Research2016，11，8： | 32 |
| 2 | The Predictive Value of Baseline HBs Ag Level and Early Response for HBs Ag Loss in Patients with HBe Ag-positive Chronic Hepatitis B during Pegylated Interferon Alpha-2a Treatment显示文摘Objective To explore the predictive value of baseline HBsAg level and early response for HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. Methods A total of 121 patients with HBeAg-positive chronic hepatitis B who achieved HBsAg loss were enrolled; all patients were treated with PEG-IFNα-2a 180 μg/week. Serum HBV DNA and serological indicators(HBsAg, anti-HBs, HBeAg, and anti-HBe) were determined before and every 3 months during treatment. Results The median treatment time for HBsAg loss was 84 weeks(7-273 weeks), and 74.38%(90 cases) of the patients needed extended treatment(> 48 weeks). The correlation between baseline HBsAg levels and the treatment time of HBsAg loss was significant(B = 14.465, t = 2.342, P = 0.021). Baseline HBsAg levels together with the decline range of HBsAg at 24 weeks significantly correlated with the treatment time of HBsAg loss(B = 29.862, t = 4.890, P = 0.000 and B = 27.993, t = 27.993, P = 0.005). Conclusion Baseline HBsAg levels and extended therapy are critical steps toward HBsAg loss. Baseline HBsAg levels together with early response determined the treatment time of HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. | LI Ming Hui ZHANG Lu QU Xiao Jing LU Yao SHEN Ge LI Zhen Zhen WU Shu Ling LIU Ru Yu CHANG Min HU Lei Ping HUA Wen Hao SONG Shu Jing WAN Gang XIE Yao | 2017 | Biomedical and Environmental Sciences2017，30，3： | 14 |
| 3 | Ectopic Expression of the Pttknl Gene Induces Alterations in the Morphology of the Leaves and Flowers in Petunia hybrida Vilm.显示文摘摘要:新奇象 knottedl 一样 homeobox (knox ) 基因, Pttknl (Populus tremula tremuloides knottedl ) ,从混合白杨的 cambial 区域孤立,被介绍进暗紫色 hybrida Vilm。由 Agrobacterium 用叶圆盘方法调停了。一系列新奇显型在转基因的暗紫色植物被观察,包括花冠的近轴的表面上的宫外的尖铁的形成,花冠中肋弄短并且花冠的离开轴心的表面上的小宠物 als ,花的机关的熔化,沿着离开轴心的表面和花冠边缘的 serrated 高球上的中肋的像肿瘤的结的形成,和在宠物 al 颜色的改变;除了在叶子和植物建筑学的变化, RT-PCR 证明 Pttknl 基因在不同暗紫色的叶子被表示转基因的植物,而没有信号在野类型的植物被检测。在叶和花开发的 Pttknl 的可能的函数被讨论。 | Xin HU Qing-Feng WU Ya-Hong XIE Hong RU Feng XIE Xin-Yu WANG Chong-Ying WAN | 2005 | Journal of Integrative Plant Biology2005，47，10： | 9 |
| 4 | DDX3X regulates cell survival and cell cycle during mouse early embryonic development显示文摘DDX3X is a highly conserved DEAD-box RNA helicase that participates in RNA transcription,RNA splicing,and mRNA transport,translation,and nucleo-cytoplasmic transport.It is highly expressed in metaphaseⅡ(MⅡ)oocytes and is the predominant DDX3 variant in the ovary and embryo.However,whether it is important in mouse early embryo development remains unknown.In this study,we investigated the function of DDX3X in early embryogenesis by cytoplasmic microinjection with its siRNA in zygotes or single blastomeres of 2-cell embryos.Our results showed that knockdown of Ddx3x in zygote cytoplasm led to dramatically diminished blastocyst formation,reduced cell numbers,and an increase in the number of apoptotic cells in blastocysts.Meanwhile,there was an accumulation of p53 in RNAi blastocysts.In addition,the ratio of cell cycle arrest during 2-cell to 4-cell transition increased following microinjection of Ddx3x siRNA into single blastomeres of 2-cell embryos compared with control.These results suggest that Ddx3x is an essential gene associated with cell survival and cell cycle control in mouse early embryos,and thus plays key roles in normal embryo development. | Qian Li Pan Zhang Chao Zhang Ying Wang Ru Wan Ye Yang Xuejiang Guo Ran Huo Min Lin Zuomin Zhou Jiahao Sha | 2014 | The Journal of Biomedical Research2014，28，4： | 4 |
| 5 | One-pot synthesis of Fe/Cu-SSZ-13 catalyst and its highly efficient performance for the selective catalytic reduction of nitrogen oxide with ammonia显示文摘Series of Fe/Cu-SSZ-13 catalysts with different Fe loading content were synthesized by simple one-pot strategy.The obtained catalysts were subjected to selective catalytic reduction(SCR)of NO x with NH 3 and were characterized by various techniques.The results show that Fe 0.63/Cu 1.50-SSZ-13 catalyst with proper Fe content exhibits excellent catalytic activity with widest operation temperature window from 160 to 580℃,excellent hydrothermal stability as well as good resistance to sulfur poisoning when compared with Cu-SSZ-13,signifying its great potential for practical applications.Further characterizations reveal that the synthesized Fe/Cu-SSZ-13 catalysts present typical chabazite(CHA)structure with good crystallinity,while isolated Cu^2+and monomeric Fe 3+are revealed as the predominant copper and iron species.At low temperatures,isolated Cu^2+species act as primary active sites for SCR reaction,while monomeric Fe^3+species provide sufficient active sites for sustain the SCR activity at high temperature.Moreover,Fe over doping would lead to the damage of zeolite structure,destruction of isolated Cu^2+site,as well as the formation of highly oxidizing Fe2O3,thus causing deterioration of catalytic performances. | Jie Wan Jiawei Chen Ru Zhao Renxian Zhou | 2021 | Journal of Environmental Sciences2021，33，2： | 3 |
| 6 | Evaluating the Quality of Case-control Studies involving the Association between Tobacco Exposure and Diseases in a Chinese Population based on the Newcastle-Ottawa Scale and Post-hoc Power显示文摘According to the 2017 Global Burden of Disease Study,smoking is among the four leading risk factors contributing to deaths and disability-adjusted life years(DALYs)in China.In the past 20 years,there has been a substantial increase in the number of studies focusing on the association between tobacco exposure and disease. | SHI Yu Lin ZHAO Jian AI Fei Ling WANG Yu Tong HU Kui Ru WANG Xue Wei YANG Wen Yi WANG Jing Xin AI Li Mei WAN Xia | 2022 | Biomedical and Environmental Sciences2022，35，9： | 2 |
| 7 | Extraction, detection, and profiling of serum biomarkers using designed Fe3O4@SiO2@HA core-shell particles显示文摘 | Chandrababu Rejeeth Xuechao Pang Ru Zhang Wei Xu Xuming Sun Bin Liu Jiatao Lou Jingjing Wan Hongchen Gu Wei Yan Kun Qian | 2018 | Nano Research2018，11，1： | 2 |
| 8 | Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study显示文摘Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women. | ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang | 2021 | Biomedical and Environmental Sciences2021，34，1： | 2 |
| 9 | Study on Sta-ble Equilibrium of Levitated Impeller in Rotary Pump with Passive Magnetic Bearings显示文摘 | Qian K X Wan F K Ru W M | | 0，，02： | 1 |
| 10 | Sequence Analysis and Overexpression of Ribosomal Protein $28 Gene (RPS28) from the Giant Panda显示文摘 | HOU Wan ru HOU Yi-ling HAO Yan zhe | 2009 | African Journal of Biotechnology2009，8，11： | 1 |
| 11 | Blast and residual capacity analysis of re- inforced concrete framed buildings 显示文摘 | Ru wan Jayasooriya David P T Nimal J P | 2011 | Engi- neering Structures2011，33，2： | 1 |
| 12 | The Association between Exposure to Second-Hand Smoke and Disease in the Chinese Population: A Systematic Review and Meta-Analysis显示文摘Objective To analyze the association between exposure to second-hand smoke(SHS) and 23 diseases,categorized into four classifications, among the Chinese population.Methods We searched the literature up to June 30, 2021, and eligible studies were identified according to the PECOS format: Participants and Competitors(Chinese population), Exposure(SHS),Outcomes(Disease or Death), and Study design(Case-control or Cohort).Results In total, 53 studies were selected. The odds ratio(OR) for all types of cancer was 1.79(1.56–2.05), and for individual cancers was 1.92(1.42–2.59) for lung cancer, 1.57(1.40–1.76) for breast cancer, 1.52(1.12–2.05) for bladder cancer, and 1.37(1.08–1.73) for liver cancer. The OR for circulatory system diseases was 1.92(1.29–2.85), with a value of 2.29(1.26–4.159) for stroke. The OR of respiratory system diseases was 1.76(1.13–2.74), with a value of 1.82(1.07–3.11) for childhood asthma. The original ORs were also shown for other diseases. Subgroup analyses were performed for lung and breast cancer. The ORs varied according to time period and were significant during exposure in the household;For lung cancer, the OR was significant in women.Conclusion The effect of SHS exposure in China was similar to that in Western countries, but its definition and characterization require further clarification. Studies on the association between SHS exposure and certain diseases with high incidence rates are insufficient. | WANG Yu Tong HU Kui Ru ZHAO Jian AI Fei Ling SHI Yu Lin WANG Xue Wei YANG Wen Yi WANG Jing Xin AILiMei WAN Xia | 2023 | Biomedical and Environmental Sciences2023，36，1： | 1 |
| 13 | Lateral interactions of trains and tracks on small radius curves: simulation and experiment显示文摘 | ZHAI Wan ruing WANG Kai-yun | 2006 | Vehicle System Dynamics2006，，： | 1 |
| 14 | Optimal tonal detectors based on the power spectrum显示文摘 | Wan Chun Ru Goh Joo Thiam and Chee Hong Tat | 2000 | IEEE Journal of Oceanic Engineering2000，25，4： | 1 |
| 15 | STUDIES ON COMPLEXES OF RARE EARTHS WITH CROWN ETHERS(V)-SYNTHESIS AND CHARACTERIZATION OF THE COMPLEXES OF RARE EARTH NITRATES WITH 2,2'-DINITRO-4,5,4',5'-BIS-(15-CROWN-5)-DIBENZO DISULFIDE显示文摘Three new solid complexes of macrocyclic polyether ligand 2, 2’-dinitro-4, 5, 4’, 5’bis-(15-crown-5)-dihenzo disulfide(L) with trivalent rare earth nitrates having composition of RE(NO3)3·L·6H2O(RE=Ce, Pr, Nd) have been synthesized in acetonitrile. All the isolated complexes have beencharacterized by elementary analysis, IR and UV spectra, differential thermal and thermogravimetricanalysis, X-ray powder diffraction analysis, molar conductance and measurements of solubility insome general solvents. | You Ming ZHANG Ai Ru LU Lian Xiang ZHANG Wan Tian ZHAO Liu Fang WANG Department of Chemistry, Northwest Normal University, 730070 Department of Chemistry, Lanzhou University, 730000 | 1992 | Chinese Chemical Letters1992，3，6： | 0 |
| 16 | Lipase-catalyzed hydrolysis of methyl-3-phenylglycidate显示文摘The enzymatic resolution of racemic methyl 3-phenylglycidate was investigated. It was found that the hydrolysis rate of (2S, 3R)-enantiomer was faster than that of (2R, 3S)-enantiomer by a new lipase. At optimal condition 96% of (2R, 3S)-methyl phenylglycidate with ee of 100% was recovered from the racemic mixture. | Guo Jun ZHENG, Jian Jun WANG, Tian Rui REN1, Liu YANG Wan Ru SUN* State Key Laboratory of Microbial Resources, Institute of Microbiology, CAS, Beijing, 100080 1Laboratory of Chemistry Computer, Institute of Chemical Metallurgy, CAS, Beijing, 100080 | 2001 | Chinese Chemical Letters2001，12，4： | 0 |
| 17 | The Preparation of Unsymmetrical Diaminodimethylsilanes and the Cleavage of Silicon-Nitrogen Bonds by Acid Chloride显示文摘Seven unsymmetrical ditaminodimethylsilanes were prepared. The reactions of these silylamine with benzoyl chloride indicated that in comparison with electronic, the steric effect played more important role on the reactivity of Si-N bond. As a new method, unsymmetrical diamide can be produced by the reaction of the title compounds with diacid chloride. | Guo Bin RONG Ru Jian MA Chong Ying ZHOU Zhu Liang JIN Wan Nian WU Qing WANG (Department of Chemistry, East China University of Science and Technology, Shanghai, 200237) | 1997 | Chinese Chemical Letters1997，8，11： | 0 |
| 18 | ERF5.1 modulates carotenoid accumulation by interacting with CCD4.1 in Lycium显示文摘Carotenoids are important natural pigments and have medical and health functions for humans.Carotenoid cleavage dioxygenase 4(CCD4)and ethylene responsive factor(ERF)participate in carotenoid metabolism,but their roles in Lycium have not been discovered.Here,we annotated LbCCDs from the Lycium reference genome and found that LbCCD4.1 expression was significantly correlated with the carotenoid metabolites during Lycium five fruit developmental stages.Over-expression of LbCCD4.1 in NQ’s leaves resulted in a series of significantly lower contents of carotenoid metabolites,includingβ-carotene andβ-cryptoxanthin.Moreover,LbERF5.1,a transcription factor belonging to the ERF family that was located in the nucleus,was isolated.Significant reductions in the carotenoids,especially lutein,violaxanthin and their derivatives,were observed in over-expressing ERF5.1 transgenic NQ’s leaves.Over-expression or virus-induced gene silencing of LbERF5.1 in NQ’s leaves induced a consistent up-or down-expression,respectively,of LbCCD4.1.Furthermore,yeast one-hybrid and dual-luciferase reporter assays showed that ERF5.1 interacted with the promoter of CCD4.1 to increase its expression,and LbERF5.1 could bind to any one of the three predicted binding sites in the promoter of LbCCD4.1.A transcriptome analysis of LbERF5.1 and LbCCD4.1 over-expressed lines showed similar global transcript expression,and geranylgeranyl diphosphate synthase,phytoene synthase,lycopeneδ-cyclase cytochrome,cytochrome P450-type monooxygenase 97A,cytochrome P450-type monooxygenase 97C,and zeaxanthin epoxidase in the carotenoid biosynthesis pathway were differentially expressed.In summary,we uncovered a novel molecular mechanism of carotenoid accumulation that involved an interaction between ERF5.1 and CCD4.1,which may be used to enhance carotenoid in Lycium. | Jianhua Zhao Yuhui Xu Haoxia Li Xinlei Zhu Yue Yin Xiyan Zhang Xiaoya Qin Jun Zhou Linyuan Duan Xiaojie Liang Ting Huang Bo Zhang Ru Wan Zhigang Shi Youlong Cao Wei An | 2023 | Horticulture Research2023，10，12： | 0 |
| 19 | Lung Cancer Risk Attributable to Active Smoking in China:A Systematic Review and Meta-Analysis显示文摘Objective No consensus exists on the relative risk(RR)of lung cancer(LC)attributable to active smoking in China.This study aimed to evaluate the unified RR of LC attributable to active smoking among the Chinese population.Methods A systematic literature search of seven databases was conducted to identify studies reporting active smoking among smokers versus nonsmokers in China.Primary articles on LC providing risk estimates with their 95%confidence intervals(CIs)for“ever”“former”or“current”smokers from China were selected.Meta-analysis was used to estimate the pooled RR of active smoking.Results Forty-four unique studies were included.Compared with that of nonsmokers,the pooled RR(95%CI)for“ever”“former”and“current”smokers were 3.26(2.79–3.82),2.95(1.71–5.08),and 5.16(2.58–10.34)among men,3.18(2.78–3.63),2.70(2.08–3.51),and 4.27(3.61–5.06)among women,and2.71(2.12–3.46),2.66(2.45–2.88),and 4.21(3.25–5.45)in both sexes combined,respectively.Conclusion The RR of LC has remained relatively stable(range,2–6)over the past four decades in China.Early quitting of smoking could reduce the RR to some extent;however,completely refraining from smoking is the best way to avoid its adverse effects. | ZHAO Jian SHI Yu Lin WANG Yu Tong AI Fei Ling WANG Xue Wei YANG Wen Yi WANG Jing Xin AI Li Mei HU Kui Ru WAN Xia | 2023 | Biomedical and Environmental Sciences2023，36，9： | 0 |
| 20 | 群落时间稳定性对刈割和养分富集的响应随时间的变化显示文摘土地利用和养分富集能对生物多样性和生态系统功能产生巨大的影响。然而,群落时间稳定性对土地利用和养分富集的响应是如何随时间变化的尚不清楚。作为历经15年(2005-2019)野外实验的一部分,本研究旨在探索在蒙古高原温带草原上,刈割、氮添加和磷添加对群落时间稳定性的效应。经过15年的实验,氮添加和磷添加均降低了群落时间稳定性,尤其是灌木和半灌木功能群的时间稳定性。刈割仅在实验早期(2005-2009)增加群落时间稳定性。氮添加在实验早期和末期(2015-2019)降低了群落时间稳定性,但在实验中期(2010-2014)反而提高了群落时间稳定性。磷添加在实验早期只轻微降低群落时间稳定性,但在实验末期显著降低群落时间稳定性。氮添加引起的群落时间稳定性变化的波动主要归因于其对物种异步性和种群时间稳定性的不同影响。我们的发现强调了植物功能群和物种异步性在调控群落时间稳定性方面的重要作用,以及仍然需要进行更长期的研究,以准确预测全球变化背景下的生态系统响应模式。 | Heng Li Jiajia Zhang Jingyi Ru Jian Song Zhensheng Chi Yujin Zheng Lin Jiang Shiqiang Wan | 2023 | Journal of Plant Ecology2023，16，4： | 0 |
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