|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice显示文摘The mammalian epididymis not only plays a fun dame ntal role in the maturati on of spermatozoa,but also provides protecti on agai nst various stressors.The foremost among these is the threat posed by oxidative stress,which arises from an imbalance in reactive oxygen species and can elicit damage to cellular lipids,proteins,and nucleic acids.In mice,the risk of oxidative damage to spermatozoa is mitigated through the expression and secretion of glutathione peroxidase 5(GPX5)as a major luminal scavenger in the proximal caput epididymidal segment.Accordingly,the loss of GPX5^-/-mediated protection leads to impaired DNA integrity in the spermatozoa of aged Gpx57 mice.To explore the underlying mechanism,we have conducted transcriptomic analysis of caput epididymidal epithelial cells from aged(13 months old)Gpx5^-/-m mice.This analysis revealed the dysregulation of several thousand epididymal mRNA transcripts,in eluding the downregulation of a subgroup of piRNA pathway gen es,in aged Gpx5^-/-mice.In agreeme nt with these fin dings,we also observed the loss of piRNAs,which potentially bind to the P-element-induced wimpy testis(PlWI)-like proteins PIWIL1 and PIWIL2.The absence of these piRNAs was correlated with the elevated mRNA levels of their putative gene targets in the caput epididymidis of Gpx5^-/-mice.Importantly,the oxidative stress response genes tend to have more targeting piRNAs,and many of them were among the top increased genes upon the loss of GPX5^-/-.Taken together,our findings suggest the existence of a previously uncharacterized somatic piRNA pathway in the mammalian epididymis and its possible invoIvement in the aging and oxidative stress-mediated responses. | Chen Chu Lu Yu Joelle Henry-Berger Yan-Fei Ru Ayhan Kocer Alexandre Champroux Zhi-Tong Li Miao He Sheng-Song Xie Wu-Bin Ma Min-Jie Ni Zi-Mei Ni Yun-Li Guo Zhao-Liang Fei Lan-Tao Gou Qiang Liu Samanta Sharma Yu Zhou Mo-Fang Liu Charlie Degui Chen Andrew L Eamens Brett Nixon Yu-Chuan Zhou Joel R Drevet Yong-Lian Zhang | 2020 | Asian Journal of Andrology2020，22，6： | 2 |
| 2 | Variation in nutritive value of commercial broiler diets 显示文摘 | Ru Y J Hughes R J Choct M Kruk J A | 2003 | Asian Australasian Journal of Animal Science2003，16，830： | 1 |
| 3 | Multiple-model estimation with variable structure-part Ⅵ: Expected-mode augmentation 显示文摘 | Li X R Jilkov V P Ru J | 2005 | IEEE Transactions on Aerospace and Electronic Systems2005，41，3： | 1 |
| 4 | Occurrence and fate of hormone teroids in the environment显示文摘 | YING G G KOOKANA R S RU Y J | 2002 | Environment Intemational2002，28，6： | 1 |
| 5 | Involvement of heine oxygenaser - 1 in delayed cardio - protection induced by monophosphcol lipid A in rats显示文摘 | Ru R Peng J Ye F | 2002 | Acta Pharmacol Sin2002，23，1： | 1 |
| 6 | The heme oxygenaser- 1 pathway invoved in calcitonin gene- related peptide- mediated delayed cardioprotection induced by monophosphoryl lipid A in rats显示文摘 | Peng J Ru R Ye F | 2002 | Regul Pept2002，103，1： | 1 |
| 7 | Multiple-model estimation with variable structure Part VI: Expected-mode augmentation显示文摘 | Li X R Ru J F | 2005 | IEEE Transactions on Aerospace and Electronic System2005，41，3： | 1 |
| 8 | Anaerobic naphthalene degradation by Gram-positive, iron-reducing bacteria显示文摘 | Kleemann R Meckenstock RU | 2011 | FEMS Microbiology Ecology2011，78，3： | 1 |
| 9 | Encapsulation of Epigallocatechin-3-gallate (EGCG) Using Oil-in-Water (O/W) Submicrometer Emulsions Stabilized by K-Carrageenan and beta-Lactoglobulin 显示文摘 | Ru Q M Yu H L Huang Q R | 2010 | Journal of Agricultural and Food Chemistry2010，58，10： | 1 |
| 10 | Multiple-model estimation with variable structure-part VI expected-mode augmentation 显示文摘 | Li X R Jilkov V P Ru J F | 2005 | IEEE Transactions on Aerospace and Electronic Systems2005，41，3： | 1 |
| 11 | Multiple drug resistant carbapenemases producing Acinetobacter baumannii isolates harbours multiple R-plasmids显示文摘 | Saranathan R Sudhakar P Karthika RU | 2014 | Indian J Med Res2014，140，2： | 1 |
| 12 | Occurrence and fate of hormone steroids in the environment显示文摘 | Ying G G Kookana R S Ru Y J | 2002 | Environment International2002，28，6： | 1 |
| 13 | Phosphorus levels influence plasma membrane H+-ATPase activity and K+,Ca2+,and Mg2+assimilation in green bean显示文摘 | Salinas R Sánchez E Ruíz J M | 2013 | Communications in Soil Science and Plant Analysis2013，44，： | 1 |
| 14 | Clonal proliferations of cells infected with Epstein-Barr virus in preinvasive lesions related to nasopharyngeal carcinoma 显示文摘 | Pathmanathan RU Prasad U Sadler R | 1995 | N Engl J Med1995，333，11： | 1 |
| 15 | Kinetic modeling of liquid- phase adsorption of reactive dyesand metallonson ehitosan显示文摘 | Feng C W Ru L T Juang R S | 2001 | Water Resource2001，35，3： | 1 |
| 16 | Appearance of the levator animuscle subdivisions in magnetic resonance images 显示文摘 | Margulies RU Kearney R Stein T | 2006 | Obstetrics Gynecology2006，107，5： | 1 |
| 17 | Bioavailability and delivery of nutraceuticals using nanotechnology 显示文摘 | Huang Q R Yu H L Ru Q M | 2010 | Journal of Food Sci- ence2010，75，1： | 1 |
| 18 | Peroxide status in tissues of heat-stressed broilers显示文摘 | Ru R Zhang Z Y | 2000 | Asian-Aus J Anim Sci2000，13，10： | 1 |
| 19 | Occurrence and fate of hormone steroids in the environment显示文摘 | YING G G KOOKANAA R S RU Y J | 2002 | Environment International2002，28，6： | 1 |
| 20 | Bioavailability and Delivery of Nutraceuticals Using Nanotechnology显示文摘 | HUANG Q R YU H L RU Q M | 2010 | Journal of Food Science2010，75，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员