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	题名	作者	年代	出处	被引量
1	Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer显示文摘AIM:To characterize tumor necrosis factor receptorassociated protein 1(TRAP1)expression in the progression of ulcerative colitis(UC)-associated colorectal cancer.METHODS:Chronic UC is an inflammatory bowel disease that predisposes to colorectal cancer.Immunohistochemical analysis was used to evaluate TRAP1expression on tissue microarrays containing colonic tissues from 42 UC progressors(patients with cancer or dysplasia)and 38 non-progressors(dysplasia/cancer free patients).Statistical analyses of the TRAP1immunohistochemistry staining were performed using Graph Pad Prism.Differences in the TRAP1 level between non-progressors and progressors were tested for statistical significance using the Mann-Whitney test.Receiver operating characteristic curve method was used to quantify marker performance in distinguishing diseased cases from controls.RESULTS:TRAP1 was up-regulated in the colon tissues from UC progressors,but not in the colon tissues from UC non-progressors.Moreover,up-regulation of TRAP1 preceded the neoplastic changes:it was present in both the dysplastic and non-dysplastic tissues of UC progressors.When TRAP1 staining in rectal tissue was used as a diagnostic marker,it could distinguish progressors from non-progressors with 59%sensitivity and 80%specificity.Our study further showed that the increase of TRAP1 expression positively correlated with the degree of inflammation in the colorectal cancer tissues,which could be related to the increased oxidation present in the colonic mucosa from UC progressors.We then investigated the cellular proteome changes underlying oxidative stress,and found that oxidative stress could induce up-regulation of TRAP1 along with several other negative modulators of apoptosis.CONCLUSION:These results suggest that oxidative stress in long standing UC could lead to the increase of cytoprotective protein TRAP1,which in turn could promote cancer progression by preventing or protecting the oxidative damaged epithelial cells from undergoing apoptosis.TRAP1 could be a potential diagnostic marker for UC associated colorectal cancer.	Ru Chen Sheng Pan Keith Lai Lisa A Lai David A Crispin Mary P Bronner Teresa A Brentnall	2014	World Journal of Gastroenterology2014，20，45：	9
2	A perspective on single molecule SERS: Current status and future challenges 显示文摘	ETCHEGOIN P G LE Ru E C	2008	Physical Chemistry Chemical Physics2008，10，40：	1
3	Multiple-model estimation with variable structure-part Ⅵ: Expected-mode augmentation 显示文摘	Li X R Jilkov V P Ru J	2005	IEEE Transactions on Aerospace and Electronic Systems2005，41，3：	1
4	Impact of Exogenous Enzymes in Sorghum-or Wheat-Based Broiler Diets on Nutrient Utilization and Growth Performance显示文摘	Selle P H Cadogan D J Ru Y J	2010	International Journal of Poultry Science2010，9，1：	1
5	New concepts and new design of permanent maglev rotary artificial heart blood pumps显示文摘	Qian KX Zeng P Ru WM	2006	Medical Engineering & Physics2006，28，：	1
6	Common intronswithin orthologous genes:software and application to plants显示文摘	WILKERSON M D RU Y BRENDEL V P	2009	Briefings in Bioinformatics2009，10，6：	1
7	V203 modified LiFePO^C composite with improved electrochemical performance 显示文摘	JIN Y YANG C P RU X H CHENG T CHEN C H	2011	J Power Sources2011，196，：	1
8	Expression of c-myc and Bcl-2 in primary and advanced cutaneous melanoma显示文摘	Utikal J Leiter U Udart M Kaskel P Peter RU Krahn GM	2002	Cancer Invest2002，20，7：	1
9	Epidemiology of HIV- TB in Asia显示文摘	Jai P Narain Ying- Ru Lo	2004	India J Med Res2004，120，4：	1
10	Multiplemodel estimation with variable structure: part VI Expected-mode augmentation 显示文摘	LI Xiaorong JILKOV V P RU Jifeng	2005	IEEE Transactions on Aerospace and Electronic Systems2005，41，3：	1
11	New Concepts and New Design of Permanent Maglev Rotary Ar-tificial Heart Blood Pumps显示文摘	Qian K X Zeng P Ru W M		0，，04：	1
12	Multiple-model estimation with variable structure-part VI expected-mode augmentation 显示文摘	Li X R Jilkov V P Ru J F	2005	IEEE Transactions on Aerospace and Electronic Systems2005，41，3：	1
13	Multiple drug resistant carbapenemases producing Acinetobacter baumannii isolates harbours multiple R-plasmids显示文摘	Saranathan R Sudhakar P Karthika RU	2014	Indian J Med Res2014，140，2：	1
14	Death substrates come alive 显示文摘	Ng P Janicke RU	1997	Bioessays1997，19，6：	1
15	New concepts and new design of permanent maglev rotary artificial heart blood pumps 显示文摘	Qian K X Zeng P Ru W M	2006	Medical Engineering & Physics2006，28，4：	1
16	Preliminary results in the therapy of psoriatic arthritis with mycophenolate mofetil显示文摘	Mooser G Peter RU	2002	Z Rheumatol2002，61，：	1
17	Two-phase dehydrogenation of aryl substituted carbzide compounds显示文摘	Wang Y L Ru C J Li J P	1994	Synth Commun1994，24，12：	1
18	Does parasitic infection protect against allergy显示文摘	Sorensen RU Sakali P		0，，：	1
19	Multiple drug resistant carbapenemases producing Acinetobacter baumannii isolates harbours multiple R-plasmids显示文摘	Saranathan R Sudhakar P Karthika RU	2014	Indian J Med Res2014，140，2：	1
20	Influence of photostability on single-molecule surface enhanced Raman scattering enhancement factors 显示文摘	ETCHEGOIN P G LACHARMOISE P D LE Ru E C	2008	Analytical Chemistry2008，81，2：	1

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