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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Production and processing of milk from transgenic goats expressing human lysozyme in the mammary gland 显示文摘 | MAGA E A SHOEMAKER C F ROWE J D | 2006 | Journal of Dairy Science2006，89，2： | 1 |
| 3 | Viscosity-Elastic Analysis of Hot Mix Asphalt Pavement显示文摘 | Rowe B Sharrock S F Bouldin M J | 1995 | Transportation Research Record1995，，1482： | 1 |
| 4 | Influence of landfill leachate suspended solids on clog (biorock) formation显示文摘 | VanGulck J F Rowe R K | | 0，，： | 1 |
| 5 | Estimation of potential impacts and natural resource damages of oil 显示文摘 | McCay F D Rowe J J | 2004 | Joumal of Haz- ard Materiats2004，107，： | 1 |
| 6 | Laboratory determination of diffusion and distribution coefficients of contaminants using undisturbed clayey soil显示文摘 | Rowe R K Caers C J Barone F | 1988 | Canadian Geotechnical Journal1988，25，1： | 1 |
| 7 | Optimization Stud ies in High Removal Rate Centreless Grinding显示文摘 | Rowe W IS Bell W F Brough D | 1986 | Annals of the CIRP1986，35，1： | 1 |
| 8 | Outcomes in persistent hyperplastic vitreous 显示文摘 | Hunt A Rowe N Lain A Martin F | 2005 | Br J Ophthalmol2005，89，： | 1 |
| 9 | Laboratory determination of diffusion and distribution coefficients of contaminants using undisturbed clayey soil显示文摘 | Rowe R K Caers C J Barone F | 1988 | Canadian Geotechnical Journal1988，25，1： | 1 |
| 10 | Faulted Structure of the Bottom Simulating Reflector on the Blake Ridge,Westem North Atlantic 显示文摘 | ROWE M M GETTRUST J F | 1993 | Geology1993，21，9： | 1 |
| 11 | Laboratory determination of diffusion and distribution coefficients of contaminants using undisturbed clayey soil显示文摘 | ROWE R K CAERS C J BARONE F | 1988 | Canadian Geotechnical Journal1988，25，1： | 1 |
| 12 | Production and processing of milk from transgenic goats expressing human lysozyme in the mammary gland显示文摘 | Maga E A Shoemaker C F Rowe J D | 2006 | J Dairy Sci2006，89，2： | 1 |
| 13 | Collage city显示文摘 | ROWE C KOETTER F | 1984 | MA : MIT Press1984，4245，： | 1 |
| 14 | Vascular imaging beforecaroti dendarterectomy显示文摘 | Norris J W Morriello F Rowed D W | 2003 | Stroke2003，34，7： | 1 |
| 15 | Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia显示文摘 | DiNardo C D Propert K J Loren A W Paietta E Sun Z X Levine R L Straley K S Yen K Patel J P Agresta S Abdel-Wahab O Perl A E Litzow M R Rowe J M Lazarus H M Fernandez H F Margolis D J Tallman M S Luger S M Carroll M | 2012 | Blood2012，121，24： | 1 |
| 16 | Laboratory determination of Diffusion and distribution coefficients of contaminants using undisturbed soil Can显示文摘 | ROWE R K CAERS C J BARONE F | 1988 | Geotech J1988，25，： | 1 |
| 17 | Modelling of clay liner desiccation显示文摘 | ZHOU Y F ROWE R K | 2005 | International Journal of Geomechanics2005，5，1： | 1 |
| 18 | Faulted structure of the bottom simulating reflector on the black Ridge, west North Atlantic 显示文摘 | Rowe M M Gettrust J F | 1993 | Geology1993，21，9： | 1 |
| 19 | The recovery and iso- topic measurement of water from fluid inclusions in spe- leothems 显示文摘 | Dennis P F Rowe P J Atkinson T C | 2001 | Geochimica et Cosmochimica Acta2001，65，： | 1 |
| 20 | Faulted structure of the bottom simulating reflector on the Blake Ridge, western North Atlantic显示文摘 | Rowe M M C ettrust J F | 1993 | Geology1993，21，： | 1 |
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