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| 1 | Lipoprotein-associated phospholipase A2 prognostic role in atherosclerotic complications显示文摘Atherosclerosis manifests itself clinically at advanced stages when plaques undergo hemorrhage and/or rupture with superimposed thrombosis, thus abruptly stopping blood supply. Identification of markers of plaque destabilization at a pre-clinical stage is, therefore, a major goal of cardiovascular research. Promising results along this line were provided by studies investigating the lipoprotein-associated phospholipase A2(Lp-PLA2), a member of phospholipase A2 proteins family that plays a key role in the metabolism of pro-inflammatory phospholipids, as oxidized low-density lipoproteins, and in the generation of pro-atherogenic metabolites, including lysophosphatidylcholine and oxidized free fatty acids. We herein review the experimental and clinical studies supporting use of Lp-PLA2 activity for predicting cardiovascular events. To his end we considered not only Lp-PLA2 activity and mass, but also Lp-PLA2 gene variations and their association with incident coronary artery disease, stroke, and cardiovascular mortality. Based on these evidences the major scientific societies have included in their guidelines the measurement of Lp-PLA2 activity among the biomarkers that are useful in risk stratification of adult asymptomatic patients at intermediate cardiovascular risk. The results of two recently published major clinical trials with the LpPLA2 inhibitor darapladib, which seem to challenge the pathogenic role of Lp-PLA2, will also be discussed. | Giuseppe Maiolino Valeria Bisogni Giacomo Rossitto Gian Paolo Rossi | 2015 | World Journal of Cardiology2015，7，10： | 66 |
| 2 | Peritoneal carcinosis of ovarian origin显示文摘Epithelial ovarian cancer (EOC) is the second most common genital malignancy in women and is the most lethal gynecological malignancy,with an estimated five-year survival rate of 39%.Despite efforts to develop an effective ovarian cancer screening method,60% of patients still present with advanced disease.Comprehensive management using surgical cytoreduction to decrease the tumor load to aminimum,and intraperitoneal chemotherapy to eliminate microscopic disease on peritoneal surface,has the potential to greatly improve quality of life and to have an impact on survival in ovarian cancer patients.Despite achieving clinical remission after completion of initial treatment,most patients (60%) with advanced EOC will ultimately develop recurrent disease or show drug resistance;the eventual rate of curability is less than 30%.Given the poor outcome of women with advanced EOC,it is imperative to continue to explore novel therapies. | Anna Fagotti Valerio Gallotta Federico Romano Francesco Fanfani Cristiano Rossitto Angelica Naldini Massimo Vigliotta Giovanni Scambia | 2010 | World Journal of Gastrointestinal Oncology2010，2，2： | 5 |
| 3 | A randomized study comparing the use of the Ligaclip with bipolar energy to prevent lymphocele during laparoscopic pelvic lymphadenectomy for gynecologic cancer显示文摘 | Gallotta V Fanfani F Rossitto C | 2010 | Am J Obstet Gynecol2010，203，5： | 1 |
| 4 | Takotsubocardiomyopathy associated with rupture of the left ventric-ular apex: assessment of histopathological features of afatal case and literature review 显示文摘 | Indorato F Akashi Y J Rossitto C | 2015 | Forensic Sci MedPathol2015，11，4： | 1 |
| 5 | The role of oxidized low-density lipoproteins in atherosclerosis: The myths and the facts显示文摘 | Maiolino G Rossitto G Caielli P | 2013 | Mediators of Inflam2013，2013，71： | 1 |
| 6 | Standardized training programmes for advanced laparoscopic gynaecological surgery 显示文摘 | Fagotti A Petrillo M Rossitto C | 2013 | Curr Opin Obstet Gynecol2013，25，4： | 1 |
| 7 | Elevation of angiotensin type-l-receptor autoantibodies titer in primary aldosteronism as a result of aldosterone-produeing adenoma显示文摘 | Rossitto G Regolisti G Rossi E | 2013 | Hypertension2013，61，2： | 1 |
| 8 | Risk of Postoperative Pelvic Abscess in Major Gynecologic Oncology Surgery: One-Year Single-Institution Experience显示文摘 | Anna Fagotti Barbara Costantini Francesco Fanfani Giuseppe Vizzielli Cristiano Rossitto Antonella Lecca Giovanni Scambia | 2010 | Annals of Surgical Oncology2010，，9： | 1 |
| 9 | Pseudoaneurysm of the hepaticartery and hemobilia: a rare complication of laparoscopic cholecys-tectomy ;clinical case and literature review 显示文摘 | Caminiti R Rossitto M Ciccolo A | 2011 | Acta Chir Belg2011，111，6： | 1 |
| 10 | Effect of se- lected dairy starter cultures on microbiological, chemical and sensory characteristics of swine and venison (Dama dama) nitrite-free dry- cured sausages显示文摘 | CENCI-GOGA B T ROSSITTO P V SECHI P | 2012 | Meat Science2012，90，2： | 1 |
| 11 | Lipoprotein-associated phospholipase A2 single-nucleotide polymorphisms and cardiovascular events in patients with coronary artery disease显示文摘 | Giuseppe Maiolino Livia Lenzini Luigi Pedon Maurizio Cesari Teresa Maria Seccia Anna Chiara Frigo Giacomo Rossitto Brasilina Caroccia Gian Paolo Rossi | 2015 | Journal of Cardiovascular Medicine2015，，1： | 1 |
| 12 | Galectin-3 predicts long- term cardiovascular death in high-risk patients with coronary artery disease显示文摘 | Maiolino G Rossitto G Pedon L | 2015 | Arterioseler Thromb Vasc Biol2015，35，3： | 1 |
| 13 | Life-threatening coagulopathy and hypofibrinogenaemia induced by tigecycline in a patient with advanced liver cirrhosis显示文摘 | Rossitto G Piano S Rosi S | 2014 | Eur J Gastroen Hepat2014，26，6： | 1 |
| 14 | Intestinal perfora-tion by ingested foreign bodies in the digestive tract:an in-sidious pathology always of interest显示文摘 | Versaci A Saladino E Rossitto M et a1 | | 0，，89： | 1 |
| 15 | The role of oxidized low - density lipoproteins in atherosclerosis: the myths and the facts 显示文摘 | Maiolino G Rossitto G Caielli P | 2013 | Mediators Irdqamm2013，，71： | 1 |
| 16 | Neutralizing epitopes of the serotypes of bluetongue virus present in the United States 显示文摘 | Rossitto V P MacLachlan J N | 1992 | J Gen Virol1992，73，： | 1 |
| 17 | The role of oxidized low- density lipoproteins in atheroselerosis: the myths and the facts 显示文摘 | Maiolino G Rossitto G Caielli P | 2013 | Mediators Inflamm2013，2013，71： | 1 |
| 18 | A randomized study comparing the use of the Ligaclip with bipolar energy to prevent lymphocele during laparoscopic pelvic lymphadenectomy for gynecologic cancer显示文摘 | Gallotta V Fanfani F Rossitto C | 2010 | Am J Obstet Gynecol2010，203，5： | 1 |
| 19 | Galectin-3 predicts longterm cardiovascular death in high-risk patients with coronary artery disease显示文摘 | Maiolino G Rossitto G Pedon L | 2015 | Arterioscler Thromb Vasc Biol2015，35，3： | 1 |
| 20 | Laparoscopic,minilaparoscopic and single-port hysterectomy:perioperative outcomes显示文摘 | Fanfani F Fagotti A Rossitto C | 2012 | Surg Endosc2012，8，： | 1 |
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