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19篇 您的检索式:作者名="Rositsa"
    题名 作者 年代 出处 被引量
1Solid-phase extraction on sorbents of different retention mechanisms followed by determination by gas chromatography-mass spectrometric and gas chromatography-electron capture detection of pesticide residues in crops 显示文摘Anna B Rositsa M Deyana S 2007Journal of Chromatography A2007,1150,12:1
2Incidence of zearalenone and fumonisins in Bulgarian cereal production 显示文摘Radostina Manova Rositsa Mladenova 2009Food Control2009,,20:1
3Solid-phase extraction on sorbents of different retention mechanisms followed by determination by gas chromatography–mass spectrometric and gas chromatography–electron capture detection of pesticide residues in crops显示文摘Anna Balinova Rositsa Mladenova Deyana Shtereva 2007Journal of Chromatography A2007,,1:1
4A general approach for modeling and mathematical investigation of the human upper limb 显示文摘Rositsa R 1992J Biomechanics1992,25,85:1
5Chromosome analysis of nuclear power plant workers using fluorescence in situ hy- bridization and Giemsa assay 显示文摘Rositsa HRISTOVA Valeria HADJIDEKOVA Mira GRIGOROVA el al 2013Journal of Radiation Research2013,18,:1
6Solid - phase extraction on sorbents of different retention mechanisms followed by determina- tion by gas chromatography- mass spectrometric and gas chroma- tography - electron capture detection of pesticide residues in crops 显示文摘Anna B Rositsa M Deyana S 2007J Chromatography A2007,1150,1:1
7Tyrosine Kinase Inhibitor Tyrphostin AG490 Retards Chronic Joint Inflammation in Mice显示文摘Valeriya Gyurkovska Tsvetanka Stefanova Petya Dimitrova Svetla Danova Rositsa Tropcheva Nina Ivanovska 2014Inflammation2014,,4:1
8Effect of Processing on Pesticide in Peaches Intended for Baby Food显示文摘BLAIONVA A M ROSITSA I 2006Food Additives and Contaminants2006,23,:1
9Chromosome analysis of nuclear power plant workers using fluorescence in situ hybridization and Giemsa assay显示文摘ROSITSA HRISTOVA VALERIA HADJIDEKOVA MIRA G 2013Journal of Radiation Research2013,54,5:1
10Differential aberrant connectivity of precuneus and anterior insula may underpin the diagnosis of schizophrenia and mood disorders显示文摘BACKGROUND Over the past decade,resting-state functional magnetic resonance imaging(rsfMRI)has concentrated on brain networks such as the default mode network(DMN),the salience network(SN),and the central executive network(CEN),allowing for a better understanding of cognitive deficits observed in mental disorders,as well as other characteristic psychopathological phenomena such as thought and behavior disorganization.AIM To investigate differential patterns of effective connectivity across distributed brain networks involved in schizophrenia(SCH)and mood disorders.METHODS The sample comprised 58 patients with either paranoid syndrome in the context of SCH(n=26)or depressive syndrome(Ds)(n=32),in the context of major depressive disorder or bipolar disorder.The methods used include rs-fMRI and subsequent dynamic causal modeling to determine the direction and strength of connections to and from various nodes in the DMN,SN and CEN.RESULTS A significant excitatory connection from the dorsal anterior cingulate cortex to the anterior insula(aI)was observed in the SCH patient group,whereas inhibitory connections from the precuneus to the ventrolateral prefrontal cortex and from the aI to the precuneus were observed in the Ds group.CONCLUSION The results delineate specific patterns associated with SCH and Ds and offer a better explanation of the underlying mechanisms of these disorders,and inform differential diagnosis and precise treatment targeting.Katrin Aryutova Rositsa Paunova Sevdalina Kandilarova Kristina Stoyanova Michael HJ Maes Drozdstoy Stoyanov 2021World Journal of Psychiatry2021,11,12:1
11Morphological features related to micropipe closing in 4H-SiC显示文摘Rositsa Yakimova N Vouroutzis Mikael Syv j rvi 2005Journal of Applied Physics2005,98,34:1
12Sensitivity of predicted muscle forces to parameters of the optimization-bnsed human leg model revealed by analytical and numerical analyses 显示文摘Rositsa T Raikova Boris I Prilutsky 2001Journal of Biomechanics2001,34,:1
13Impulsive control for a class of neural networks withbounded and unbounded delays显示文摘Ivanka M Stamova I Rajcho I Rositsa V 2010Applied Mathematics and Computation2010,216,1:1
14A model of the flexion -extension motion in the elbow joint -some problems concerning muscle forces modelling and computation显示文摘Rositsa Raikova 1996J Biomechanics1996,29,6:1
15Laboratory Obtaining of Ferroalloy after Reduction of Oxides from Waste Product and Natural Resource显示文摘Petar Petrov Maksim Marinov Rositsa Paunova 2013Journal of Environmental Science and Engineering(B)2013,2,1:0
16Synthesis and Structure of bc-Dichloro-af-dihydroxo-de-bis(N-3-pyridinylmethanesulfonamide)platinum(Ⅳ) Diydrate显示文摘The Pt(Ⅳ) complex cis,cis,trans-[Pt(PMSA)2Cl2(OH)2]2H2O (1), where PMSA=N-3-pyridinylmethanesulfonamide, has been synthesized and characterized by elemental analysis, molar electric conductivity and IR spectrum. X-ray crystallography revealed that the title compound crystallizes in the monoclinic C2/c space group with unit cell dimensions a=16.5424(7), b=8.6973(3), c=16.6079(6) , β=117.185(5)o and Z=4. Pt(Ⅳ) has an octahedral coordination geometry and the PMSA ligands are coordinated via the pyridine N atom. They are in a transoid orientation between each other and are inclined in the same direction with respect to the Pt-Cl-Cl i -N-N i plane at an angle of 64.6(1) o (symmetry operation: (i) 1 x, y, 3/2 z). The structure is stabilized by a system of hydrogen bonds involving the complex and water molecules.Nicolay I. DODOFF Boris L. SHIVACHEV Rositsa P. NIKOLOVA Maria LALIA-KANTOURI Vesna MILETI Tamara I. PAJPANOVA 2012Chinese Journal of Structural Chemistry2012,31,10:0
17Maillard reaction and immunogenicity of protein therapeutics显示文摘The recombinant DNA technology enabled the production of a variety of human therapeutic proteins.Accumulated clinical experience,however,indicates that the formation of antibodies against such proteins is a general phenomenon rather than an exception.The immunogenicity of therapeutic proteins results in inefficient therapy and in the development of undesired,sometimes life-threatening,side reactions.The human proteins,designed for clinical application,usually have the same amino acid sequence as their native prototypes and it is not yet fully clear what the reasons for their immunogenicity are.In previous studies we have demonstrated for the first time that interferon-b(IFN-b)pharmaceuticals,used for treatment of patients with multiple sclerosis,do contain advanced glycation end products(AGEs)that contribute to IFN-b immunogenicity.AGEs are the final products of a chemical reaction known as the Maillard reaction or glycation,which implication in protein drugs' immunogenicity has been overlooked so far.Therefore,the aim of the present article is to provide a comprehensive overview on the Maillard reaction with emphasis on experimental data and theoretical consideration telling us why the Maillard reaction warrants special attention in the context of the welldocumented protein drugs' immunogenicity.Rositsa Tsekovska Angelina Sredovska-Bozhinov Toshimitsu Niwa Ivan Ivanov Roumyana Mironova 2016World Journal of Immunology2016,6,1:0
18Functional magnetic resonance imaging study of group independent components underpinning item responses to paranoid-depressive scale显示文摘BACKGROUND Our study expand upon a large body of evidence in the field of neuropsychiatric imaging with cognitive,affective and behavioral tasks,adapted for the functional magnetic resonance imaging(MRI)(fMRI)experimental environment.There is sufficient evidence that common networks underpin activations in task-based fMRI across different mental disorders.AIM To investigate whether there exist specific neural circuits which underpin differ-ential item responses to depressive,paranoid and neutral items(DN)in patients respectively with schizophrenia(SCZ)and major depressive disorder(MDD).METHODS 60 patients were recruited with SCZ and MDD.All patients have been scanned on 3T magnetic resonance tomography platform with functional MRI paradigm,comprised of block design,including blocks with items from diagnostic paranoid(DP),depression specific(DS)and DN from general interest scale.We performed a two-sample t-test between the two groups-SCZ patients and depressive patients.Our purpose was to observe different brain networks which were activated during a specific condition of the task,respectively DS,DP,DN.RESULTS Several significant results are demonstrated in the comparison between SCZ and depressive groups while performing this task.We identified one component that is task-related and independent of condition(shared between all three conditions),composed by regions within the temporal(right superior and middle temporal gyri),frontal(left middle and inferior frontal gyri)and limbic/salience system(right anterior insula).Another com-ponent is related to both diagnostic specific conditions(DS and DP)e.g.It is shared between DEP and SCZ,and includes frontal motor/language and parietal areas.One specific component is modulated preferentially by to the DP condition,and is related mainly to prefrontal regions,whereas other two components are significantly modulated with the DS condition and include clusters within the default mode network such as posterior cingulate and precuneus,several occipital areas,including lingual and fusiform gyrus,as well as parahippocampal gyrus.Finally,component 12 appeared to be unique for the neutral condition.In addition,there have been determined circuits across components,which are either common,or distinct in the preferential processing of the sub-scales of the task.CONCLUSION This study has delivers further evidence in support of the model of trans-disciplinary cross-validation in psychiatry.Drozdstoy Stoyanov Rositsa Paunova Julian Dichev Sevdalina Kandilarova Vladimir Khorev Semen Kurkin 2023World Journal of Clinical Cases2023,11,36:0
19Implications from translational cross-validation of clinical assessment tools for diagnosis and treatment in psychiatry显示文摘Traditional therapeutic methods in psychiatry,such as psychopharmacology and psychotherapy help many people suffering from mental disorders,but in the long-term prove to be effective in a relatively small proportion of those affected.Therapeutically,resistant forms of mental disorders such as schizophrenia,major depressive disorder,and bipolar disorder lead to persistent distress and dysfunction in personal,social,and professional aspects.In an effort to address these problems,the translational approach in neuroscience has initiated the inclusion of novel or modified unconventional diagnostic and therapeutic techniques with promising results.For instance,neuroimaging data sets from multiple modalities provide insight into the nature of pathophysiological mechanisms such as disruptions of connectivity,integration,and segregation of neural networks,focusing on the treatment of mental disorders through instrumental biomedical methods such as electro-convulsive therapy(ECT),transcranial magnetic stimulation(TMS),transcranial direct current stimulation(tDCS)and deep brain stimulation(DBS).These methodologies have yielded promising results that have yet to be understood and improved to enhance the prognosis of the severe and persistent psychotic and affective disorders.The current review is focused on the translational approach in the management of schizophrenia and mood disorders,as well as the adaptation of new transdisciplinary diagnostic tools such as neuroimaging with concurrently administered psychopathological questionnaires and integration of the results into the therapeutic framework using various advanced instrumental biomedical tools such as ECT,TMS,tDCS and DBS.Katrin Aryutova Rositsa Paunova Sevdalina Kandilarova Anna Todeva-Radneva Drozdstoy Stoyanov 2021World Journal of Psychiatry2021,11,5:0
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