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| 1 | Assessment of liver ablation using cone beam computed tomography显示文摘AIM: To investigate the feasibility and accuracy of cone beam computed tomography(CBCT) in assessing the ablation zone after liver tumor ablation.METHODS: Twenty-three patients(17 men and 6 women, range: 45-85 years old, mean age 65 years) with malignant liver tumors underwent ultrasoundguided percutaneous tumor ablation [radiofrequency(n = 14), microwave(n = 9)] followed by intravenous contrast-enhanced CBCT. Baseline multidetector computed tomography(MDCT) and peri-procedural CBCT images were compared. CBCT image quality was assessed as poor, good, or excellent. Image fusion was performed to assess tumor coverage, and quality of fusion was rated as bad, good, or excellent. Ablation zone volumes on peri-procedural CBCT and post-procedural MDCT were compared using the nonparametric paired Wilcoxon t-test.RESULTS: Rate of primary ablation effectiveness was 100%. There were no complications related to ablation. Local tumor recurrence and new liver tumors were found 3 mo after initial treatment in one patient(4%). The ablation zone was identified in 21/23(91.3%) patients on CBCT. The fusion of baseline MDCT and peri-procedural CBCT images was feasible in all patients and showed satisfactory tumor coverage(at least 5-mm margin). CBCT image quality was poor, good, and excellent in 2(9%), 8(35%), and 13(56%), patients respectively. Registration quality between periprocedural CBCT and post-procedural MDCT images was good to excellent in 17/23(74%) patients. The median ablation volume on peri-procedural CBCT and post-procedural MDCT was 30 cm3(range: 4-95 cm3) and 30 cm3(range: 4-124 cm3), respectively(P-value > 0.2). There was a good correlation(r = 0.79) between the volumes of the two techniques. CONCLUSION: Contrast-enhanced CBCT after tumor ablation of the liver allows early assessment of the ablation zone. | Mohamed Abdel-Rehim Maxime Ronot Annie Sibert Valérie Vilgrain | 2015 | World Journal of Gastroenterology2015，21，2： | 6 |
| 2 | Disease control with sunitinib in advanced intrahepatic cholangiocarcinoma resistant to gemcitabine-oxaliplatin chemotherapy显示文摘Advanced cholangiocarcinoma is associated with poor prognostic survival and has limited therapeutic options available at present. The importance of angiogenesis and expression of pro-angiogenic factors in intrahepatic forms of cholangiocarcinoma suggest that therapies targeting angiogenesis might be useful for the treatment of this disease. Here we report three cases of patients with advanced intrahepatic cholangiocarcinoma progressive after standard chemotherapy and treated with sunitinib 50 mg/d in 6-wk cycles of 4 wk on treatment followed by 2 wk off treatment(Schedule 4/2). In all three patients, sunitinib treatment was associated with a sustained disease control superior to 4 mo, patients achieving either a partial response or stable disease. A reduction in tumor size and density was observed in all cases, suggesting tumor necrosis as a result of sunitinib treatment in these patients. In addition, sunitinib was generally well tolerated and the occurrence of side effects was managed with standard medical interventions, as required. Our results suggest that sunitinib therapy maybe associated with favorable outcomes and tolerability in patients with advanced cholangiocarcinoma. Those observations contributed to launch a prospective phase Ⅱ multicenter trial investigating sunitinib in advanced intrahepatic cholangiocarcinoma(SUN-CK study; NCT01718327). | Chantal Dreyer Marie-Paule Sablin Mohamed Bouattour Cindy Neuzillet Maxime Ronot Safi Dokmak Jacques Belghiti Nathalie Guedj Valérie Paradis Eric Raymond Sandrine Faivre | 2015 | World Journal of Hepatology2015，7，6： | 4 |
| 3 | Hepatocellular adenomas:accuracy of magnetic resonance imaging and liver biopsy in subtype classification显示文摘 | Ronot M Bahrami S Calderaro J | 2011 | Hepatology2011，53，4： | 1 |
| 4 | Complete regression of locally advanced hepatocellular carcinoma in- duced by sorafenib allowing curative resection显示文摘 | IRTAN S CHOPIN-LALY X RONOT M | 2011 | Liver Int2011，31，5： | 1 |
| 5 | Can we justify not doing liver perfusion imaging in 20137 显示文摘 | RONOT M LAMBERT S DAIRE J L | 2013 | Diagn Interv Imaging2013，94，12： | 1 |
| 6 | Liver fibrosis in chronic hepatitis C virus infection: differentiating minimal from intermediate fibrosis with perfusion CT显示文摘 | Ronot M Asselah T~ Paradis V | 2010 | Radiology2010，256，1： | 1 |
| 7 | Ultrasound assessment of gastric volume in critically ill patients 显示文摘 | Hamada SR Garcon P Ronot M | 2014 | Intensive Care Med2014，40，7： | 1 |
| 8 | Complete regression of locally advanced hepatoceUular carcinoma induced by sorafenib allowing curative resection显示文摘 | Irtan S Laly XC Ronot M et aI | 2011 | Liver Int2011，31，5： | 1 |
| 9 | The PvdRT- OpmQ efflux pump controls the metal selectivity of the iron uptake pathway mediated by the siderophore pyoverdine in Pseudomonas aeruginosa显示文摘 | Hannauer M Braud A Hoegy F Ronot P | 2012 | Environ Microbiol2012，14，7： | 1 |
| 10 | Rotenone inhibits the mitochondrial permeability transition-induced cell death in U937 andKB cells显示文摘 | Chauvin C De Oliveira F Ronot X | 2001 | J Biol Chem2001，276，41： | 1 |
| 11 | Imaging response in neuro- endocrine tumors treated with targeted therapies : the experi- ence of sunitinib显示文摘 | Faivre S Ronot M Dreyer C | 2012 | Target Oncol2012，7，2： | 1 |
| 12 | MR findings of steatotic focal nodular hyperplasia and comparison with other fatty tumours显示文摘 | Maxime Ronot Valérie Paradis Rafael Duran Anne Kerbaol Marie-Pierre Vullierme Jacques Belghiti Dominique-Charles Valla Valérie Vilgrain | | European Radiology0，，： | 1 |
| 13 | High-b-valuediffusion -weighted mr imaging of benign hepatocellularlesions: quantitative and qualitative analysis 显示文摘 | Agnello F Ronot M Valla DC | 2012 | Radiology2012，262，2： | 1 |
| 14 | High-b-value diffusion-weigh- ted MR imaging of benign hepatocellular lesions: quantitative and qualitative analysis显示文摘 | Agnello FI Ronot M Valla DC | 2012 | Radiology2012，262，： | 1 |
| 15 | Can we justify not doing liverperfusion imaging in 2013? 显示文摘 | Ronot M Lambert S Daire JL | 2013 | Diagn Interv Imaging2013，94，12： | 1 |
| 16 | Characterization of cell deformation and migration using a parametric estimation of image motion显示文摘 | Germain F Doisya Ronot X | 1999 | Biomedical Engineering IEEE Transactions on1999，46，5： | 1 |
| 17 | Telangiectatic adenoma: an entity associated with increased body mass index and inflammation 显示文摘 | Paradis V Champault A Ronot M | 2007 | Hepatology2007，46，1： | 1 |
| 18 | Lemmel's syndrome as a rare cause of obstructive jaundice 显示文摘 | Rouet J Gaujoux S Ronot M | 2012 | Clin Res Hepatol Gastroenterol2012，36，： | 1 |
| 19 | Modulation of P - glyeopretein mediated multidrog resistance by flavonoid derivatives and analogues 显示文摘 | Hadjeri M Barbier M Ronot X | 2003 | ivied Chem2003，46，11： | 1 |
| 20 | Quantitative study of dynamic behavior of cell monolayers during in vitro wound healing by optical flow analysis显示文摘 | Ronot X Doisy A Tracqui P | 2000 | Cytometry2000，41，1： | 1 |
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