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| 1 | Immunohistochemical expression of thymidylate synthase and prognosis in gastric cancer patients submitted to fluoropyrimidine-based chemotherapy显示文摘Objective: Adjuvant chemotherapy with 5-fluorouracil(5-FU) has been widely used in gastric cancer(GC)patients to prevent relapse after curative resection. 5-FU acts by inhibiting thymidylate synthase(TS), and high levels of TS correlate with resistance to treatment with fluoropyrimidines. The aim of this study was to evaluate the expression of TS in GC patients, and its relation with clinicopathological characteristics and prognosis in adjuvant chemotherapy with 5-FU.Methods: We retrospectively evaluated 285 patients who underwent D2-gastrectomy with curative intent. TS expression was determined by immunohistochemistry(IHC) in tumor cells by tissue microarray(TMA). TS level was evaluated according to the intensity and percentage of cells marked by a score system. Patients were divided in three groups according to their TS-score: negative, low and high.Results: TS expression was positive in 92.3% of GC. TS-high, TS-low and TS-negative were observed in46.3%, 46.0% and 7.7% of patients, respectively. High-TS GC were associated with older age(P=0.007), high neutrophil/lymphocyte ratio(P=0.048), well/moderately differentiated histology(P=0.001), intestinal Lauren type(P<0.001) and absence of perineural invasion(P=0.003). Among 285 patients, 133 stage Ⅱ/Ⅲ patients(46.7%)received chemotherapy with 5-FU. In survival analysis, TS-high was associated with worse disease-free survival(DFS) in stage Ⅲ GC patients who received 5-FU-based chemotherapy(P=0.007). Multivariate analysis revealed that total gastrectomy, poorly differentiated tumors and high TS-score were associated with worse DFS in stage Ⅲ GC patients.Conclusions: High TS-score in stage Ⅲ GC was associated with poor DFS in patients treated with fluoropyrimidine-based chemotherapy. | Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos ANDre Roncon Dias Sheila Friedrich Faraj Cinthya dos Santos Cirqueira EvANDro Sobroza de Mello Bruno Zilberstein Venancio Avancini Ferreira Alves Ulysses Ribeiro Jr | 2018 | Chinese Journal of Cancer Research2018，30，5： | 3 |
| 2 | Helicobacter pylori Induces Increased Expression of Toll‐Like Receptors and Decreased Toll‐Interacting Protein in Gastric Mucosa that Persists Throughout Gastric Carcinogenesis显示文摘 | Pedro Pimentel‐Nunes Nádia Gon?alves Inês Boal‐Carvalho Luís Afonso Paula Lopes Roberto Roncon‐Albuquerque Rui Henrique Luís Moreira‐Dias Adelino F. Leite‐Moreira Mário Dinis‐Ribeiro | 2012 | Helicobacter2012，，1： | 2 |
| 3 | Prognostic implications of tumor-infiltrating lymphocytes in association with programmed cell death ligand 1 expression in remnant gastric cancer显示文摘Objective:Remnant gastric cancer(RGC)is usually associated with a worse prognosis.As they are less common and very heterogeneous tumors,new prognostic and reliable determinants are required to predict patients’clinical course for RGC.This study aimed to investigate the tumor-infiltrating lymphocytes(TILs)and programmed cell death ligand 1(PD-L1)status as prognostic biomarkers in a cohort of patients with RGC to develop an immunerelated score.Methods:Patients with gastric cancer(GC)who underwent curative intent gastrectomy were retrospectively investigated.RGC resections with histological diagnosis of gastric adenocarcinoma were enrolled in the study.The risk score based on immune parameters was developed using binary logistic regression analysis.RGCs were divided into high-risk(HR),intermediate-risk(IR),and low-risk(LR)groups based on their immune score.The markers(CD3+,CD4+/CD8+T cells and PD-L1)were selected for their potential prognostic,therapeutic value,and evaluated by immunohistochemistry(IHC).Results:A total of 42 patients with RGC were enrolled in the study.The score based on immune parameters exhibited an accuracy of 79%[the area under the receiver operating characteristic curve(AUC)=0.79,95%confidence interval(95%CI),0.63-0.94,P=0.002],and the population was divided into 3 prognostic groups:10(23.8%)patients were classified as LR,15(35.7%)as IR,and 17(40.5%)as HR groups.There were no differences in clinicopathological and surgical characteristics between the three groups.In survival analysis,HR and IR groups had worse disease-free survival and overall survival rates compared to the LR group.In the multivariate analysis,lymph node metastasis and the immune score risk groups were independent factors related to worse survival.Conclusions:A scoring system with immune-related markers was able to distinguish prognostic groups of RGC associated with survival.Accordingly,tumor-infiltrating immune lymphocytes and PD-L1 status may serve as a potential prognostic biomarker for patients with RGC. | Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos André Roncon Dias Leonardo Cardili Rafael Dyer Rodrigues de Moraes Renan Ribeiro E Ribeiro Venancio Avancini Ferreira Alves Bruno Zilberstein Evandro Sobroza de Mello Ulysses Ribeiro Jr | 2022 | Chinese Journal of Cancer Research2022，34，6： | 1 |
| 4 | Gaussian beams from variable groove depth grating couplers in planar waveguide显示文摘 | Bates K A Li L F Roncone R L | 1993 | Appl Opt1993，32，： | 1 |
| 5 | Prophylactic endovascular management of peripheral artery disease in elderly candidates prior to cardiac surgery显示文摘Background and objectives Peripheral vascular disease (PVD) is a major risk factor in candidates for cardiac surgery and can impact morbidity and mortality in the perioperative and follow-up period. Elderly patients with PVD may benefit from endovascular treatment prior to cardiac surgery. We sought to assess the common clinical settings requiring prophylactic endovascular treatment before coronary surgery in elderly patients, the results, and the mid-term impact on subsequent revascularization. Methods Between November 2002 and June 2006, 37 patients (25 males, mean age 79.9±8.3 years, mean serum creatinine 1.9±0.6 mg/dl) underwent endovascular repair of PVD before cardiac surgery. For each patient, diagnostic methods, indications for intervention, types of interventions, procedural success, and complications were recorded. Results Four clinical settings were identified: renal artery stenting prior to coronary surgery (7 patients), iliac artery angioplasty and stenting (10 patients) in order to facilitate aortic balloon pump insertion after surgery, subclavian artery angioplasty and stenting prior to utilization of ipsilateral arterial conduits bypass surgery (5patients), and carotid artery stenting before coronary surgery (15 patients). Technical success was achieved in all patients (100%);complications included brachial artery occlusion (1 patient), minor stroke (2 patients), contrast nephropathy (1 patient), and minor bleeding at the puncture site (3 patients). All patients underwent successful coronary or valvular surgery; no patients died in the perioperative period. After a mean follow-up of 26.6±3.1 months, all patients are alive and free from anginal symptoms or valvular dysfunction without clinical or Doppler ultrasonography evidence of restenosis of the implanted peripheral vascular stents. Conclusions It is not unusual for elderly patients who are candidates for cardiac surgery to require endovascular intervention for significant PVD prior to coronary bypass or valvular surgery. The results showed a low complication rate. The cardiologists have a fundamental role,not only in the diagnosis of peripheral vascular stenosis, which was seen frequently in patients with significant CAD, but also in the appropriate endovascular management of these high-risk patients. | Gianluca Rigatelli Paolo Cardaioli Massimo Giordan Loris Roncon Emiliano Bedendo Tranquillo Milan Giorgio Rigatelli | 2006 | Journal of Geriatric Cardiology2006，3，2： | 1 |
| 6 | Plasma catecholamines in Buerger's disease: effects of cigarette smoking and surgical sympathectomy 显示文摘 | Roncon Albuquerque R Serrao P Vale Pereira R | 2002 | Eur J Vasc Endovasc Surg2002，24，4： | 1 |
| 7 | Transanal endoscopic microsurgery: indications, results and controversies显示文摘 | Andre Roncon Dias Caio Sergio Rizkallah Nahas Carlos Frederico Sparapan Marques Sergio Carlos Nahas Ivan Cecconello | 2009 | Techniques in Coloproctology2009，，2： | 1 |
| 8 | Attenua-tion of the cardiovascular and metabolic complications of obesityin CD14 knockout mice显示文摘 | Roncon R Albuquerque Jr Moreira-Rodrigues M | 2008 | Life Sciences2008，83，： | 1 |
| 9 | APOE kyoto mutation inEuropean Americans with lipoprotein glomemlopathy 显示文摘 | Rovin BI-I Roncone D McKinley A | 2007 | N Engl J Med2007，357，24： | 1 |
| 10 | Biliary stone causing afferent loop syndrome and pancreatitis显示文摘We report the case of an 84-year-old female who had a partial gastrectomy with Billroth-II anastomosis 24 years ago for a benign peptic ulcer who now presented an acute pancreatitis secondary to an afferent loop syndrome. The syndrome was caused by a gallstone that migrated through a cholecystoenteric fi stula. This is the fi rst description in the literature of a biliary stone causing afferent loop syndrome. | André Roncon Dias Roberto Iglesias Lopes | 2006 | World Journal of Gastroenterology2006，12，38： | 1 |
| 11 | Cardiorenalsyndrome 显示文摘 | RONCON C HAAPIO M HOUSE AA | 2008 | J Am Coll Cardiol2008，52，19： | 1 |
| 12 | Cardiovascular actions of adi- ponectin: Pathophysiologic implications 显示文摘 | Maia - Fernandes T Roncon - Albuquerque R Leite Moreira AF | 2008 | Rev Port Cardiol2008，27，11： | 1 |
| 13 | Acute Daialysis Quality Initiative (ADQI):The PASSPORT project显示文摘 | Roncon C | 2005 | Int J Artif Organs2005，28，5： | 1 |
| 14 | Acute Dialysis Quality Initiative ( ADQI ) : The PASS- PORT project 显示文摘 | Roncon C | 2005 | Int J Artif Organs2005，28，5： | 1 |
| 15 | Purtscher's retinopathy显示文摘 | Roncone DP | 2002 | Optometry2002，73，3： | 1 |
| 16 | The role of lipopolysaccharide/toll - like receptor 4 signaling in chronic liver diseases 显示文摘 | Soares J B Pimentel - Nunes P Roncon - Albuquerque R | 2010 | Hepatol Int2010，4，4： | 1 |
| 17 | The role of lipopolysaccharide/toll - like receptor 4 signaling in chronic River diseases 显示文摘 | Soares JB Pimentel - Nunes P Roncon - Albuquerque R | 2010 | Hcpatol Int2010，4，4： | 1 |
| 18 | An uncommon coronary artery fistula显示文摘 | Massimo Giordan Gianluca Rigatelli Massimo Rinuncini Loris Roncon Gabriele Braggion Stefano Panin Emiliano Bedendo Pietro Zonzin | 2005 | Cardiovascular Revascularization Medicine2005，，3： | 1 |
| 19 | Reactive nitrogen species generated by heme proteins: mechanism of formation and targets显示文摘 | Roncone R Barbieri M Monzani E | 2006 | Coordination Chemistry Reviews2006，250，11： | 1 |
| 20 | Follow up after spontane- ous coronary artery dissection:A report of five Cases显示文摘 | Zampieri P Aggio S Roncon L at al | 1996 | Heart1996，75，2： | 1 |
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