|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Endoscopic transluminal pancreatic necrosectomy using a self-expanding metal stent and high-flow water-jet system显示文摘Walled-off pancreatic necrosis and a pancreatic abscess are the most severe complications of acute pancreatitis. Surgery in such critically ill patients is often associated with significant morbidity and mortality within the first few weeks after the onset of symptoms. Minimal invasive approaches with high success and low mortality rates are therefore of considerable interest. Endoscopic therapy has the potential to offer safe and effective alternative treatment. We report here on 3 consecutive patients with infected walled-off pancreatic necrosis and 1 patient with a pancreatic abscess who underwent direct endoscopic necrosectomy 19-21 d after the onset of acute pancreatitis. The infected pancreatic necrosis or abscess was punctured transluminally with a cystostome and, after balloon dilatation, a non-covered self-expanding biliary metal stent was placed into the necrotic cavity. Following stent deployment, a nasobiliary pigtail catheter was placed into the cavity to ensure continuous irrigation. After 5-7 d, the metal stent was removed endoscopically and the necrotic cavity was entered with a therapeutic gastroscope. Endoscopic debridement was performed via the simultaneous application of a high-flow water-jet system; using a flush knife, a Dormia basket, and hot biopsy forceps. The transluminal endotherapy was repeated 2-5 times daily during the next 10 d. Supportive care included parenteral antibiotics and jejunal feeding. All patients improved dramatically and with resolution of their septic conditions; 3 patients were completely cured without any further complications or the need for surgery. One patient died from a complication of prolonged ventilation severe bilateral pneumonia, not related to the endoscopic procedure. No procedure related complications were observed. Transluminal endoscopic necrosectomy with temporary application of a self-expanding metal stent and a high-flow water-jet system shows promise for enhancing the potential of this endoscopic approach in patients with walled-off pancreatic necrosis and/or a pancreatic abscess. | István Hritz Roland Fejes András Székely Iván Székely László Horváth gnes Sárkány ron Altorjay László Madácsy | 2013 | World Journal of Gastroenterology2013，19，23： | 10 |
| 2 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 3 | Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery 显示文摘 | BROMBERG L E RON E S | 1998 | Advanced Drug Delivery Reviews1998，31，3： | 1 |
| 4 | Soil zoology:an indispensable component of integrated ecosystem studies显示文摘 | RON G G L IJBERT B | 2002 | European Journal of Soil Biology2002，38，： | 1 |
| 5 | Organizational decision support system for effective R&D project selection 显示文摘 | TIAN Q MA J LIANG J RON C W K OU L | 2005 | Decision Support Systems2005，39，3： | 1 |
| 6 | Rising thyroid cancer incidence in the united states by demographic and tumor charactristics, 1980 : 2005 显示文摘 | Enewold L Zhu K Ron E | 2009 | Cancer Epidemiol Biomarkers Prey2009，18，3： | 1 |
| 7 | Nonradiation risk factors for thyroid cancer in the US Radiologic Teehnol ogistsStudy显示文摘 | Meinhold C L Ron E Schonfeld S J | 2010 | Am J Epidemiol2010，171，2： | 1 |
| 8 | Pathogen- induced programmed cell death in tobacco 显示文摘 | Ron M Lee S Eric L | 1997 | Joumal of Ceil Science1997，110，： | 1 |
| 9 | Rising thyroid cancer incidence in the United States by demographic and tumor characteristics,1980-2005显示文摘 | Enewold L Zhu K Ron E | | 0，，03： | 1 |
| 10 | Caloric equivalent of live weight loss of dairy cattle显示文摘 | Th Bath D L Ronning M Meyer J H | 1965 | J Dairy Sci1965，48，： | 1 |
| 11 | Impact of ultrafiltration and nanofiltration of an industrial fish protein hydrolysate on its bioactive properties显示文摘 | Picot L Ravallec R Fouchereau-Péron M | 2010 | Journal of the Science of Food and Agriculture2010，90，11： | 1 |
| 12 | 成人2型糖尿病不同筛查及预防策略成本效益分析显示文摘目的 比较针对2型糖尿病预防及治疗的4种筛查策略及随后予以的干预措施:(a)筛查2型糖尿病患者使其能接受早期检查及治疗,(b)筛查2型糖尿病和糖耐量受损患者,对糖耐量受损的人群予以生活方式干预以延缓或预防糖尿病的发生,(c)同(b)但予以药物干预措施,(d)不筛查。
设计 成本效益决策分析建立在对概率的发展和评估基础上,是从筛查到死亡的综合性经济决策分析模型。
研究对象 一组假设人群,筛查时年龄45岁,高于平均糖尿病风险水平。
数据来源 电子书目数据库收录的已发表的临床试验和流行病学研究;补充数据分别来自英国和威尔士健康统计署、风险筛查(STAR)研究和ADDITION研究的Leicester部分。
方法 建立一种决策树/Markov混合模型,以模拟每一种筛查策略的长期效用,包括临床和成本效益终点。该模型假设水平跨度为50年时间,其成本效益折损率为3.5%。采用敏感度分析以验证模型假设及确定哪种模型数据输入对结果的影响最大。
结果 与不筛查策略比较,筛查2型糖尿病、筛查糖尿病和糖耐量受损并予以生活方式干预、筛查糖尿病和糖耐量受损并予以药物干预治疗3种策略,每获得一个质量调整生命年(QALY)估计所需成本分别为(每年成本效益贴现率为3.5%)14150英镑(17560欧元;27860美元)、6242英镑和7023英镑。在支付意愿阈值为20000英镑时,各主动筛查策略通过干预产生的成本效益概率分别为49%,93%和85%。
结论 对年龄45岁、高于平均风险水平的人群进行2型糖尿病和糖耐量受损的筛查,并对糖耐量受损人群予以适当的干预似乎具有很好的成本效益。单独筛查糖尿病而不对糖耐量受损人群予以干预的策略具有的成本效益仍不确定,需要进一步研究确定早期检测糖尿病的作用。 | Clare L Gillies Paul C Lambert Keith R Abrams Alex J Sutton Nicola J Cooper Ron T Hsu Melanie J Davies Kamlesh Khunti 张晓梅(译) 纪立农(校) | 2008 | 英国医学杂志中文版2008，11，5： | 1 |
| 13 | Identification of genes potentially involved in rupture of human atherosclerotic plaques显示文摘 | Birgit C G F Kitty B J M C Ron L J N | 2001 | Circ Res2001，89，6： | 1 |
| 14 | Harmony:Static noise analysis of deep submicron digital integrated circuits显示文摘 | Shepard Kenneth L Narayanan Vinod Rose Ron | 1999 | IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems1999，18，8： | 1 |
| 15 | A fractal-based algorithm for detecting first arrivals on seismic traces显示文摘 | Mike D D Ron D L | 1993 | Geophysics1993，61，4： | 1 |
| 16 | Temperature-responsive gels and thermo gelling polymer matrices for protein and peptide delivery显示文摘 | Bromberg L E Ron E S | 1998 | Adv Drug Deliv Rev1998，31，： | 1 |
| 17 | Progress of mandibular condyle lesion in juvnile rheumatoid arthritis显示文摘 | Ronning O Valiaho M - L | 1981 | Proc Finn Dent Soc1981，77，： | 1 |
| 18 | Deformation mechanism in high strength Cu/Nb nanocomposites显示文摘 | Thilly L Véron M Ludwig O Lecouturier F | 2001 | Mater Sci Eng A2001，309，： | 1 |
| 19 | A new optical pumping scheme using a frequency modulated semi-conductor laser for 4 He magnetometers显示文摘 | B. Chéron H. Gilles J. Hamel O. Moreau E. No?l | 1995 | Optics Communications1995，，1： | 1 |
| 20 | Rising thyroid cancer incidence in the United States by demographic and tumor characteristics, 1980-2005显示文摘 | Enewold L Zhu K Ron E | 2009 | Cancer Epidemiol Biomarkers Prey2009，18，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员