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| 1 | Effect of diminazene aceturate,levamisole and vitamin C combination therapy in rats experimentally infected with Trypanosoma brucei brucei显示文摘Objective:To investigate the effect of diminazene aceturale(DA) alone or in combination with either levamisole and/or Vitamin C in albino rats experimentally infected with Trypanosoma brucei brucei.Methods:Thirty adult male albino rats,randomly assigned into 6 groups(A—F) of 5rats each were used.They were either infected with 1×10~a trypanosomes intraperitoneally(groups A-E) or uninfected(group F).The different groups were treated respectively as follows:group A-with 3.5 mg/kg DA;group B-3.5 mg/kg DA and 7.5 mg/kg levamisole;group C-3.S mg/kg DA and 100 mg/kg vitamin C;and group D-3.S mg/kg DA and 7.S mg/kg levamisole and 100 mg/kg vitamin C.Croup E was left untreated.Parameters assessed include:rectal temperature,body weight changes,packed cell volume(PCV),Haemoglobin concentration(Hb),total leucocyte count(TLC) differential leucocyte count(DLC),parasitaemia,clinical signs and survivability.Results:Average pre-patent period of 5 days was recorded.Parasites in the blood were cleared in all treated groups(A-D) within 48 hours post treatment(PT).Untreated rats in group E died between25 and 32 days post infection(PI).Relapse was not recorded in all the treated groups(A-D).The initial reduction in PCV,Hb,TLC and increases in rectal temperature following infection were reversed by the treatments.The rats that received drug combinations(groups B,C and D)showed faster and higher recovery rates than the uninfected control and group A.Conclusions:Levamisole and/or Vitamin C combination with DA were more effective in the treatment of rats infected with Trypanosoma brucei brucei. | Adieme Ijeoma Chekwube Ezeh Ikenna Onyema Ugochukwu Emmanuel Ikenna Romanus Chukwuduruo Ezeokonkwo | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，6： | 3 |
| 2 | Auditor Industry Specialization, Auditor Changes, and Accounting Restatements显示文摘 | Romanus RN Maher J J Fleming DM | 2008 | Accounting Horizons2008，22，4： | 1 |
| 3 | Lung cancer treatment casts, including patient responsibility, by disease stage and treatment modality, 1992 to 2003显示文摘 | Cipriano LE Romanus D Earle CC | 2011 | Value Health2011，14，1： | 1 |
| 4 | 显示文摘 | Erler F Jakob C Romanus H | 2003 | Electrochimica Acta2003，48，： | 1 |
| 5 | A comparison of quality of life before and after arthroplasty in patients who had arthrosis of hip joint显示文摘 | Wickland I Romanus B | 1991 | J Bone Joint Surg(Am)1991，73，7： | 1 |
| 6 | Meeting the 12 lymph node(LN)benchmark in colon cancer显示文摘 | Raiput A Romanus D Weiser MR | 2010 | J Surg Oncol2010，102，1： | 1 |
| 7 | Interface behaviour in nickel composite coatings with nano-particles oxidic ceramic显示文摘 | ERLER F JAKOB C ROMANUS H | 2003 | Electrochimica Acta2003，48，2022： | 1 |
| 8 | Comparison of separation performance between single and two inlets hydro-cyclones 显示文摘 | ROMANUS K HIDETO Y | 2009 | Advanced Powder Technology2009，20，2： | 1 |
| 9 | Separation performance of sub-micron silica particles by electrical hydrocyclone显示文摘 | Romanus Krisantus Tue Nenu Hideto Yoshida Kunihiro Fukui Tetsuya Yamamoto | 2009 | Powder Technology2009，，2： | 1 |
| 10 | Mycobacterium avium lymphadenopathy among children Sweden显示文摘 | THEGERSTROM J ROMANUS V FRIMAN V | 2008 | Emerg Infect Dis2008，14，4： | 1 |
| 11 | Thermoplastic resins for flexible framework removable partial dentures显示文摘 | Negrutiu M Sinescu C Romanu M | 2005 | TMJ2005，55，3： | 1 |
| 12 | Pelvic strength after majoramputation of the sacrum:an experimental study显示文摘 | Gunterberg B Romanus B Stener B | 1976 | Acta OrthopScand1976，476，： | 1 |
| 13 | Pelvic strength after major amputation of the sacrum:an experimental study显示文摘 | Unterberg B Romanus B Stener B | | 0，，10： | 1 |
| 14 | Pelvic strength after major amputation of the sacrum: an experimental study 显示文摘 | Gunterberg B Romanus B Stener B | 1976 | Acta Orthop Scand1976，47，6： | 1 |
| 15 | Pelvic strength after major amputation of the sacrum:an experimental study显示文摘 | Gunterberg B Romanus B Stener B | 1976 | Acta Orthop Scand1976，47，6： | 1 |
| 16 | Do Changes in Decision Weights Account for Effects of Prior Outcomes on Risky Decisions显示文摘 | Romanus J Garling T | 1999 | Acta Psychologica1999，101，1： | 1 |
| 17 | Three-dimensional characteristic of cartilaginous and bony components of dysplastic hip in children:three-dimensional computed tomography quantitative analysis显示文摘 | Romanus B Sutherland DH | 1997 | J of Pediatric Orthop1997，17，： | 1 |
| 18 | Taurine supplement in early life altered islet morphology, decreased insulitis and delayed the onset of diabetes in non-obese diabetic mice显示文摘 | Arany E Strutt B Romanus P | 2004 | Diabetologia2004，47，： | 1 |
| 19 | Interface behaviour in nickel composite coatings with nano-particles of oxidic ceramic显示文摘 | Erler F Jakob C Romanus H | 2003 | Electrochimica Acta2003，48，2022： | 1 |
| 20 | Automous growth of a human neuroblastoma cell line is mediated by insulin-like growth factor- Ⅱ 显示文摘 | E I-Badry OM Romanus JA Helman LJ | 1989 | J Clin Invest1989，84，3： | 1 |
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