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| 1 | 血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。 | 徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P | 2014 | 神经病学与神经康复学杂志2014，11，3： | 19 |
| 2 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 3 | High-flow nasal oxygen availability for sedation decreases the use of general anesthesia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasound显示文摘AIM To examine whether high-flow nasal oxygen(HFNO) availability influences the use of general anesthesia(GA) in patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) and endoscopic ultrasound(EUS) and associated outcomes.METHODS In this retrospective study, patients were stratified into 3 eras between October 1, 2013 and June 30, 2014 based on HFNO availability for deep sedation at the time of their endoscopy. During the first and last 3-mo eras(era 1 and 3), no HFNO was available, whereas it was an option during the second 3-mo era(era 2). The primary outcome was the percent utilization of GA vs deep sedation in each period. Secondary outcomes included oxygen saturation nadir during sedation between periods, as well as procedure duration, and anesthesia-only time between periods and for GA vs sedation cases respectively.RESULTS During the study period 238 ERCP or EUS cases were identified for analysis. Statistical testing was employed and a P < 0.050 was significant unless the Bonferroni correction for multiple comparisons was used. General anesthesia use was significantly lower in era 2 compared to era 1 with the same trend between era 2 and 3(P = 0.012 and 0.045 respectively). The oxygen saturation nadir during sedation was significantly higher in era 2 compared to era 3(P < 0.001) but not between eras 1 and 2(P = 0.028) or 1 and 3(P = 0.069). The procedure time within each era was significantly longer under GA compared to deep sedation(P ≤ 0.007) as was the anesthesia-only time(P ≤ 0.001).CONCLUSION High-flow nasal oxygen availability was associated with decreased GA utilization and improved oxygenation for ERCP and EUS during sedation. | Roman Schumann Nikola S Natov Klifford A Rocuts-Martinez Matthew D Finkelman Tom V Phan Sanjay R Hegde Robert M Knapp | 2016 | World Journal of Gastroenterology2016，22，47： | 9 |
| 4 | 诊断性试验和策略的证据质量和推荐强度的分级显示文摘GRADE系统能对诊断性试验或策略的证据质量和推荐强度进行分级。本文旨在阐释在此过程中如何考虑患者的重要结局, | Holger J Schünemann Andrew D Oxman Jan Brozek Paul Glasziou Roman Jaeschke Gunn E Vist John W Williams Jr Regina Kunz Jonathan Craig Victor M Montori Patrick Bossuyt Gordon H Guyatt 李晓 黄程 陈耀龙 李幼平 | 2009 | 中国循证医学杂志2009，9，5： | 7 |
| 5 | 应用无标定激光诱导击穿光谱法分析钢铁工业中氧化物材料显示文摘激光诱导击穿光谱技术是一种具有吸引力的快速定量表征材料的方法,可用于工业过程的在线监控。本文报告了该技术在多元氧化物材料分析上应用。采用激光诱导击穿光谱技术分析钢工业生产的炉渣和混合氧化物试料,然后以无标定法测定其中氧化物的浓度,结果发现,对于本研究所涉及的材料,无标定激光诱导击穿光谱方法的测定浓度值与参考值一致,大部分样品和氧化物组分的绝对误差小于2%(质量分数),大范围改变测定参数时浓度值保持稳定。研究结果表明激光诱导击穿光谱技术作为钢铁工业中新型的分析测试技术具有很大潜力。 | PEDARNIG Johannes D HEITZ Johannes PRAHER Bernhard KOLMHOFER Philipp HUBER Norbert RSSLER Roman WOLFMEIR Hermann ARENHOLZ Enno | 2012 | 冶金分析2012，32，8： | 2 |
| 6 | GRADE:在推荐分级中体现对资源利用的考虑显示文摘指南小组成员对资源利用是否会影响个体患者的治疗决策有不同看法。由于医疗费用上涨,必须考虑资源利用的影响,但指南小组成员可能会发现这有很大的挑战性。 | Gordon H Guyatt Andrew D Oxman Regina Kunz Roman Jaeschke Mark Helfand Alessandro Liberati Gunn E Vist Holger J Schьnemann 王菊芬 陈耀龙 李幼平 | 2009 | 中国循证医学杂志2009，9，6： | 2 |
| 7 | Trough levels and antibodies to infliximab may not predict response to intensification of infliximab therapy in patients with inflammatory bowel disease显示文摘 | Benjamin Pariente Guillaume Pineton de Chambrun Roman Krzysiek Marine Desroches Gauthier Louis Chiara De Cassan Clotilde Baudry Jean‐Marc Gornet Pierre Desreumaux Dominique Emilie Jean‐Frédéric Colombel Matthieu Allez | 2011 | Inflamm Bowel Dis2011，，7： | 2 |
| 8 | Hazards to space missions from microbial biofilms 显示文摘 | MITCHELL R GU J D ROMAN M | 1996 | Biodeterior Biodegrad1996，133，： | 1 |
| 9 | Solvent-dependent dynamic stereochemistry about Fe in ferrocenyleyclohexenones and access to optically active CpFe + arene salts显示文摘 | Astruc D Abbayes H D | 1981 | J Organomet Chem1981，219，： | 1 |
| 10 | Phase II trial of capecitabineand docetaxel for locally advanced and metastatic pancreatic cancerpreviously treated with gemcitabine based therapy显示文摘 | Blaya M Lopes G D Roman E et a1 | 2007 | J Clin On-col2007，25，15： | 1 |
| 11 | Speech segregation based on sound localization 显示文摘 | Roman N Wang D L Brown G J | 2003 | Journal of Acoustic Society of America2003，114，4： | 1 |
| 12 | Tile role of microbial biofilms in deterioration of space station candidate materials 显示文摘 | GU J D ROMAN M ESSELMAN T | 1998 | Int Biodeterior Biodegrad1998，41，： | 1 |
| 13 | Effect of reaction conditions on the properties and behavior of wood cellulose nanocrystal suspensions显示文摘 | Beck-Candanedo S Roman M Gray D G | 2005 | Biomacromolecules2005，6，2： | 1 |
| 14 | Efficacy and tolerability of donepezil in vascular dementia: positive results of a 24- week, multicenter, international, randomized, placebo-controlled clinical trial显示文摘 | BLACK S ROMAN G C GELDMACHER D S | 2003 | Stroke2003，34，10： | 1 |
| 15 | Effect of reaction conditions on the properties and behavior of wood cellulose nanocrystal suspensions显示文摘 | Beck-Candanedo S Roman M Gray D G | 2005 | Biomacromolecules2005，6，2： | 1 |
| 16 | Evidences of chemical interaction between EVA and hydrating Portland cement显示文摘 | SILVA D A ROMAN H R GLEIZE P J P | 2002 | Cement and Concrete Research2002，32，9： | 1 |
| 17 | Oxygen uptake/supply dependency: effects of short - term dobutamine infusion 显示文摘 | Vincent JL A Roman D De Backer | 1990 | Am Rev Respir Dis1990，142，： | 1 |
| 18 | Web service model-ing ontology 显示文摘 | Roman D Keller U Lausen H | 2005 | Applied Ontology2005，1，1： | 1 |
| 19 | Surface and subsurface characterization of epoxy - mesoporous silica composites to clarify tribological properties显示文摘 | M C Romanes N A DSouza D Coutinho | 2008 | Wear2008，265，12： | 1 |
| 20 | The use of epiphyton and epilithon data as a base for calculating ecological indices in monitoring of eutrophication in lakes in central Sweden 显示文摘 | Roman A D Ekelund N G A | 2000 | The Science of the Total Environment2000，，248： | 1 |
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