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| 1 | Potential role of killer immunoglobulin receptor genes among individuals vaccinated against hepatitis B virus in Lebanon显示文摘AIM To explore the role of killer immunoglobulin receptor(KIR) genes in responsiveness or non-responsiveness to vaccination against hepatitis B virus.METHODS We recruited 101 voluntary participants between March 2010 and December 2011. Sera samples from vaccinated and non-vaccinated participants were tested for the presence of anti-HBs antibodies as a measure of protection against hepatitis B, hepatitis B surface antigen and hepatitis B core antibody as indicators ofinfection by enzyme-linked immunosorbent assay. KIR gene frequencies were determined by polymerase chain reaction.RESULTS Sera samples from 99 participants were tested for the levels of anti-HBs as an indicator of protection(≥ 10 mI U/ml) following vaccination as defined by the World Health Organization international reference standard. Among the vaccinated participants, 47%(35/74) had anti-HBs titers above 100 mI U/ml, 22%(16/74) had antiHBs ranging between 10-100 mI U/ml, and 20%(15/74) had values of less than 10 mI U/ml. We report the lack of significant association between the number of vaccine dosages and the titer of antibodies among our vaccinated participants. The inhibitory KIR2Dl1, KIR2Dl4, KIR3Dl1, KIR3Dl2, and KIR3 Dl were detected in more than 95%, whereas KIR2Dl2, KIR2Dl3, KIR2Dl5(KR2Dl5A and KIR2Dl5B) were expressed in 56%, 84% and 42%(25% and 29%) of participants, respectively. The observed frequency of the activating KIR genes ranged between 35% and 55% except for KIR2DS4, detected in 95% of the study participants(40.6% 2DS4*001/002; 82.2% 2DS4*003/007). KIR2DP1 pseudogene was detected in 99% of our participants, whereas KIR3DP*001/02/04 and KIR3DP1*003 had frequencies of 17% and 100%, respectively. No association between the frequency of KIR genes and anti-HBs antibodies was detected. When we compared the frequency of KIR genes between vaccinated individuals with protective antibodies titers and those who lost their protective antibody levels, we did not detect a significant difference. KIR2Dl5 B was significantly different among different groups of vaccinated participants(group Ⅰ > 100 mI U/ml, group Ⅱ 10-100 mI U/ml, group Ⅲ < 10 mI U/ml and group Ⅳ with undetectable levels of protective antibodies). CONCLUSION To our knowledge, this is the first study screening for the possible role of KIR genes among individuals vaccinated against hepatitis B virus(HBV). Our results can be used to design larger studies to better understand the role of KIR genes in protection against or susceptibility to HBV post vaccination. | Nada M Melhem Rami A Mahfouz Khalil Kreidieh Rabab Abdul-Khalik Rolla El-Khatib Reem Talhouk Umayya Musharrafieh Ghassan Hamadeh | 2016 | World Journal of Hepatology2016，8，29： | 2 |
| 2 | Human papillomavirus viralload expressed as relative light units(RLU)correlates with the pres-ence and grade of preneoplastic lesions of the uterine cervix inatypical squamous cells of undetermined significance(ASCUS)cytology显示文摘 | Origoni M Carminati G Rolla S | 2012 | Eur J Clin Microbiol Infect Dis2012，31，9： | 1 |
| 3 | W-curing of formulations by means of polymeric photoinitiators with the active 2, 6-dimethylbenzoylphosphine oxide moieties pendant from a tetramethylene side chain 显示文摘 | Castclvetro V Molest M Rolla P | 2002 | Macromol Chem Pbys2002，203，1011： | 1 |
| 4 | UV-curing of acrylic formulations by means of polymeric photoinitiators with the active 2,6 - dimethylbenzoylphosphine oxide moieties pendant from a tetramethylene side chain 显示文摘 | CASTELVETRO V MOLESTI M ROLLA P | 2002 | Macromolecular Chemistry Physics2002，203，： | 1 |
| 5 | Efficient Routing Heuristics for Internet Traffic Engineering显示文摘 | Salles R M Rolla V G | 2007 | Computer Communications2007，30，9： | 1 |
| 6 | Randomised prospective study of abdominal wall closure in patients with gynaecological cancer显示文摘 | Berretta R Rolla M Patrelli TS | 2010 | Aust N Z J Obstet Gynaecol2010，50，4： | 1 |
| 7 | Human papilloma- virus viral load expressed as relative light units(RLU) correlates with the presence and grade of preneoplastic le- sions of the uterine cervix in atypical squamous cells of undetermined significance (ASCUS) cytology 显示文摘 | Origoni M Carminati G Rolla S | 2012 | Eur J Clin Microbiol Infect Dis2012，31，9： | 1 |
| 8 | Role of the laboratory in mo-nitoring patients receiving dual antiplatelet therapy显示文摘 | Vidali M Rolla R Parrella M | 2012 | Int J LabHematol2012，34，5： | 1 |
| 9 | Compatibilization and properties of lyoly (ethylene terephthalate)/polyethylene blends based on recycled materials 显示文摘 | Pracella M Rolla L Chionna D | 2002 | Maeromolecular Chemistry and Physics2002，203，1011： | 1 |
| 10 | Isola- ted ovarian relapse of pre-B acute lymphoblastic leuke- mia:a case report显示文摘 | BERRETTA R BARONE A ROLLA M | 2009 | J Pediatr Adolesc Gynecol2009，22，： | 1 |
| 11 | Role of the laboratory in monitor- ing patients receiving dual antiplatelet therapy 显示文摘 | Vidali M Rolla R Parrella M | 2012 | Int J Lab Hematol2012，34，： | 1 |
| 12 | Role of the laboratory in mo nitoring patients receiving dual antiplatelet therapy显示文摘 | Vidali M Rolla R Parrella M | 2012 | Int J Lab Hematol2012，34，5： | 1 |
| 13 | Isolated ovarian relapse of Pre-B acute lymphoblastic leukemia: a case report 显示文摘 | Berretta R Barone A Rolla M | 2009 | Pediatr Adolesc Gyneco12009，22，： | 1 |
| 14 | Warning nonrespiratory symp- toms in asthma: catastrophic abdominal involvement in a case of Ghurg-Strauss syndrome显示文摘 | Rolla G Tartaglia N Motta M | 2007 | Ann Allergy Asthma Immuno2007，95，6： | 1 |
| 15 | Human papillomavirus viral load expressed as relative light units (RLU) correlates with the presence and grade of preneoplastie lesions of the uterine cervix in a- typical squamous cells of undetermined significance (ASCUS) cytol-ogy显示文摘 | Origoni M Carminati G Rolla S | 2012 | Eur J Clin Microbiol Infect Dis2012，31，9： | 1 |
| 16 | Desorption of acquired enamel pellicle in vivo by pyrophosphate显示文摘 | Rykke M Rolla G | 1990 | Scand J Dent Res1990，98，3： | 1 |
| 17 | Compatibilization and properties of poly(ethylene terephthalate)/polyethylene blends based on recycled materials显示文摘 | Pracella M Rolla L Chionna D | | 0，，10： | 1 |
| 18 | Recent insinght into therapy of con - gestive heart failure; focus on ALEinhibition and angiotensin- Ⅱ antagono- ism 显示文摘 | Rolla M Vaddadi G | 1999 | JNMcell Cardiol1999，33，5： | 1 |
| 19 | Desorption of acquired enalmel pellicle in vivo by pyrophosphate显示文摘 | Rykke M Rolla G | 1990 | Scand J Dent Res1990，98，3： | 1 |
| 20 | Effect on dyspnoea and hypoxaemia of inhaled N G -nitro-L-arginine methyl ester in hepatopulmonary syndrome显示文摘 | L Brussino C Bucca M Morello E Scappaticci M Mauro G Rolla | 2003 | The Lancet . 2003 (9377)2003，，9377： | 1 |
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