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| 1 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 2 | Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organizer,formation of the body axes and specification of ventral cell fates显示文摘 | Rana AA Barbera JP Rodriguez TA | 2004 | Development2004，131，20： | 1 |
| 3 | Prevention of seromas formation after dissection of musculo - skeletal flaps显示文摘 | Coons MS Folliget TA Rodriguez C | 1993 | Am Surg1993，59，： | 1 |
| 4 | Giant serous cystadenoma arising from an accessory ovary in a morbidly obese 11-year-old girl:a case report显示文摘 | Sharatz SM Trevi(n)o TA Rodriguez L | 2008 | J Med Case Reports2008，2，： | 1 |
| 5 | The meiotic checkpoint monitoring synapsis eliminstes spermatocytes via p53-independent apoptosis 显示文摘 | Odorisio t Rodriguez TA Evans EP | 1998 | Natl Genet1998，18，3： | 1 |
| 6 | Prevention of seromas formation after dissection of masculo-skeletal flaps显示文摘 | Coons MS Folliget TA Rodriguez C | 1993 | Am Surg1993，59，： | 1 |
| 7 | Concordance rate of alopecia areata in identical twins supports both genetic and environmental factors显示文摘 | Rodriguez TA Fernandes KE Dresser KL | | 0，，03： | 1 |
| 8 | : Metabolic engineering of Arabidopsis and Brassica for poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer production显示文摘 | Slater S Mitsky TA Houmiel KL Hao M Reiser SE Taylor NB Tran M Valentin HE Rodriguez DJ Stone DA | 1999 | Nat Biotechnol1999，17，： | 1 |
| 9 | New Models of Collaboration in Genome -wide Association Studies: the ge- netic association information Network 显示文摘 | Manolio TA Rodriguez LL Brooks L | 2007 | Nature Genet- ics2007，39，9： | 1 |
| 10 | Induction of cell death by endogenous nerve growth factor through its p75 receptor显示文摘 | Frade JM Rodriguez TA Barde YA | 1996 | Nature1996，383，： | 1 |
| 11 | Prevention of seromas formation after dissection of musculo skeletal flaps显示文摘 | Coons MS Folliget TA Rodriguez C | 1993 | Am Surg1993，59，4： | 1 |
| 12 | The meiotic checkpoint monitoring synapsis eliminates spermatocytes via p53-independent apoptosis显示文摘 | Odorisio T Rodriguez TA Evans EP | 1998 | Nat Genet1998，18，3： | 1 |
| 13 | Concordance rate of alopeciaareata in identical twins supports both genetic and en-vironmental factors显示文摘 | Rodriguez TA Fernandes KE Dresser KL Nationalalopecia areata registry | 2010 | J Am Acad Dermatol2010，62，3： | 1 |
| 14 | Identification of IL11RA and MELK amplification in gastric cancer by comprehensive genomic profiling of gastric cancer cell lines显示文摘AIM To identify common copy number alterations on gastric cancer cell lines.METHODS Four gastric cancer cell lines(ACP02, ACP03, AGP01 and PG100) underwent chromosomal comparative genome hybridization and array comparative genome hybridization. We also confirmed the results by fluorescence in situ hybridization analysis using the bacterial artificial chromosome clone and quantitative real time PCR analysis.RESULTS The amplification of 9p13.3 was detected in all cell lines by both methodologies. An increase in the copy number of 9p13.3 was also confirmed by fluorescence in situ hybridization analysis. Moreover, the interleukin 11 receptor alpha(IL11RA) and maternal embryonic leucine zipper kinase(MELK) genes, which are present in the 9p13.3 amplicon, revealed gains of the MELK gene in all the cell lines studied. Additionally, a gain in the copy number of IL11 RA and MELK was observed in 19.1%(13/68) and 55.9%(38/68) of primary gastric adenocarcinoma samples, respectively. CONCLUSION The characterization of a small gain region at 9p13.3 in gastric cancer cell lines and primary gastric adenocarcinoma samples has revealed MELK as a candidate target gene that is possibly related to the development of gastric cancer. | Danielle Queiroz Calcagno Sylvia Santomi Takeno Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Elizabeth Suchi Chen Taíssa Maíra Thomaz Araújo Eleonidas Moura Lima Maria Isabel Melaragno Samia Demachki Paulo Pimentel Assumpcao Rommel Rodriguez Burbano Marília Cardoso Smith | 2016 | World Journal of Gastroenterology2016，22，43： | 0 |
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